(data stored in ACNUC31183 zone)

SWISSPROT: Q08E64_BOVIN

ID   Q08E64_BOVIN            Unreviewed;       663 AA.
AC   Q08E64; F1MVZ0;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   30-AUG-2017, entry version 87.
DE   SubName: Full=RAP1 GTPase activating protein {ECO:0000313|EMBL:AAI23396.1, ECO:0000313|Ensembl:ENSBTAP00000011785};
GN   Name=RAP1GAP {ECO:0000313|EMBL:AAI23396.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000011785};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000313|EMBL:AAI23396.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI23396.1};
RC   TISSUE=Thalamus {ECO:0000313|EMBL:AAI23396.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
RA   Siddiqui A., Holt R., Jones S.J., Marra M.A.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000011785, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011785,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000011785}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011785};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; DAAA02006473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02006474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02006475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC123395; AAI23396.1; -; mRNA.
DR   RefSeq; NP_001070356.1; NM_001076888.1.
DR   RefSeq; XP_015315861.1; XM_015460375.1.
DR   UniGene; Bt.54732; -.
DR   STRING; 9913.ENSBTAP00000011785; -.
DR   Ensembl; ENSBTAT00000011785; ENSBTAP00000011785; ENSBTAG00000008952.
DR   GeneID; 532839; -.
DR   KEGG; bta:532839; -.
DR   CTD; 5909; -.
DR   eggNOG; KOG3686; Eukaryota.
DR   eggNOG; ENOG410XTIX; LUCA.
DR   GeneTree; ENSGT00760000119182; -.
DR   HOGENOM; HOG000231640; -.
DR   HOVERGEN; HBG016371; -.
DR   KO; K17700; -.
DR   OMA; YPKNTDL; -.
DR   OrthoDB; EOG091G028T; -.
DR   TreeFam; TF318626; -.
DR   Reactome; R-BTA-392517; Rap1 signalling.
DR   Reactome; R-BTA-8853659; RET signaling.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000008952; -.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR003109; GoLoco_motif.
DR   InterPro; IPR000331; Rap_GAP_dom.
DR   Pfam; PF02188; GoLoco; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00390; GoLoco; 1.
DR   SUPFAM; SSF111347; SSF111347; 1.
DR   PROSITE; PS50877; GOLOCO; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q08E64.
DR   SWISS-2DPAGE; Q08E64.
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   GTPase activation {ECO:0000256|PROSITE-ProRule:PRU00165};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN      181    397       Rap-GAP. {ECO:0000259|PROSITE:PS50085}.
SQ   SEQUENCE   663 AA;  73464 MW;  D51B76D6BD31CD05 CRC64;
     MIEKMQGSRM DEQRCSFPPP LKTEEDYIPY PSVHEVLGRE GPFPLILLPQ FGGYWIEGTN
     HEITSIPETE PLQSPTTKVK LECNHTARLY RKHFLGKEHF NYYSLDTALG HLVFSLKYDV
     IGDQEHLRLL LRTKCRTYHD VIPISCLTEF PNVVQMAKLV CEDVNVDRFY PVLYPKASRL
     IVTFDEHVIS NNFKFGVIYQ KLGQTSEEEL FSTNEESPAF VEFLEFLGQK VKLQDFKGFR
     GGLDVTHGQT GTESVYCNFR NKEIMFHVST KLPYTEGDAQ QLQRKRHIGN DIVAVVFQDE
     NTPFVPDMIA SNFLHAYVVV QAEGGGPDGP LYKVSVTARD DVPFFGPPLP DPAVFRKGPE
     FQEFLLTKLI NAEYACYKAE KFAKLEERTR AALLETLYEE LHIHSQSMMG LGGDEDKMEN
     GGGGGGFFES FKRVIRSRSQ SMDAMGLSNK KPHTVSTSHS GSFTPNNPDL AKAAGISLIV
     PGKSPTRKKS GPFGSRRSSA IGIENIQEVQ EKRESPPAGQ KTPDSGHVSQ EPKSENSSTQ
     SSPEMPTTKN RAETVAQRAE VLKDFSRSSS SASSFASVVE EAEGVDADDT GLESVSSSGT
     PHKRDSFIYS TWLEDSISTT SGGSSPGPSR SPHPDAGKLG DPACPEIKIQ LEASEQHTPQ
     LGC
//

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