(data stored in SCRATCH zone)

SWISSPROT: Q0SKC3_RHOJR

ID   Q0SKC3_RHOJR            Unreviewed;       317 AA.
AC   Q0SKC3;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   07-JUN-2017, entry version 80.
DE   RecName: Full=Beta-lactamase {ECO:0000256|RuleBase:RU361140, ECO:0000256|SAAS:SAAS00129357};
DE            EC=3.5.2.6 {ECO:0000256|RuleBase:RU361140, ECO:0000256|SAAS:SAAS00129357};
GN   OrderedLocusNames=RHA1_ro00177 {ECO:0000313|EMBL:ABG92013.1};
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG92013.1, ECO:0000313|Proteomes:UP000008710};
RN   [1] {ECO:0000313|Proteomes:UP000008710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710};
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M.,
RA   Fernandes C., Miyazawa D., Wong W., Lillquist A.L., Wang D.,
RA   Dosanjh M., Hara H., Petrescu A., Morin R.D., Yang G., Stott J.M.,
RA   Schein J.E., Shin H., Smailus D., Siddiqui A.S., Marra M.A.,
RA   Jones S.J.M., Holt R., Brinkman F.S.L., Miyauchi K., Fukuda M.,
RA   Davies J.E., Mohn W.W., Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- CATALYTIC ACTIVITY: A beta-lactam + H(2)O = a substituted beta-
CC       amino acid. {ECO:0000256|RuleBase:RU361140,
CC       ECO:0000256|SAAS:SAAS00129358}.
CC   -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC       {ECO:0000256|RuleBase:RU361140, ECO:0000256|SAAS:SAAS00559532}.
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DR   EMBL; CP000431; ABG92013.1; -; Genomic_DNA.
DR   RefSeq; WP_009472722.1; NC_008268.1.
DR   ProteinModelPortal; Q0SKC3; -.
DR   STRING; 101510.RHA1_ro00177; -.
DR   MEROPS; S11.A01; -.
DR   PRIDE; Q0SKC3; -.
DR   EnsemblBacteria; ABG92013; ABG92013; RHA1_ro00177.
DR   GeneID; 4217596; -.
DR   KEGG; rha:RHA1_ro00177; -.
DR   PATRIC; fig|101510.16.peg.202; -.
DR   eggNOG; ENOG4108J4B; Bacteria.
DR   eggNOG; COG2367; LUCA.
DR   HOGENOM; HOG000201073; -.
DR   KO; K17836; -.
DR   OMA; FKTLACA; -.
DR   OrthoDB; POG091H023N; -.
DR   BioCyc; RJOS101510:GJJ1-177-MONOMER; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR000871; Beta-lactam_class-A.
DR   InterPro; IPR023650; Beta-lactam_class-A_AS.
DR   PRINTS; PR00118; BLACTAMASEA.
DR   SUPFAM; SSF56601; SSF56601; 1.
DR   PROSITE; PS00146; BETA_LACTAMASE_A; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q0SKC3.
DR   SWISS-2DPAGE; Q0SKC3.
KW   Antibiotic resistance {ECO:0000256|RuleBase:RU361140,
KW   ECO:0000256|SAAS:SAAS00063120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008710};
KW   Hydrolase {ECO:0000256|RuleBase:RU361140,
KW   ECO:0000256|SAAS:SAAS00483625, ECO:0000313|EMBL:ABG92013.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008710};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    317       Beta-lactamase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5004176589.
SQ   SEQUENCE   317 AA;  33042 MW;  F3685DF4A9B33E65 CRC64;
     MSTHRNHPKP RRTGRRGAVA LALALPLLLG ACTATAEQAQ PTTSVAAIPD RRSLDATIDA
     LEAQYSTRIG VTAVNPATGE VYSHRGDERF AMCSTFKAYA SAAVLRKTED GSTSLDKTVV
     IEPGDLVENS PVTAAAVGAP MTLGQIAEAA LTQSDNTAGN YLLREIGGPQ AITALARDVG
     DGGTRLDRWE TELNTAFRDD PRDTTTPNGL AQGFRALLLG DALDTASRDQ LLEWMRASKT
     SDKRMRAGLP TGWTAADKTG GGGFGTANDA GVAWSPDGAP LVLAILTDSL TNQQDAQGNN
     QAIADTTAAV IEGLTAP
//

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