(data stored in SCRATCH zone)

SWISSPROT: Q13EU9_RHOPS

ID   Q13EU9_RHOPS            Unreviewed;       305 AA.
AC   Q13EU9;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   08-MAY-2019, entry version 88.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00667901};
DE            EC=6.3.2.6 {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00337892};
DE   AltName: Full=SAICAR synthetase {ECO:0000256|HAMAP-Rule:MF_00137};
GN   Name=purC {ECO:0000256|HAMAP-Rule:MF_00137};
GN   OrderedLocusNames=RPD_0150 {ECO:0000313|EMBL:ABE37390.1};
OS   Rhodopseudomonas palustris (strain BisB5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316057 {ECO:0000313|EMBL:ABE37390.1, ECO:0000313|Proteomes:UP000001818};
RN   [1] {ECO:0000313|EMBL:ABE37390.1, ECO:0000313|Proteomes:UP000001818}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BisB5 {ECO:0000313|EMBL:ABE37390.1,
RC   ECO:0000313|Proteomes:UP000001818};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Pelletier D.A., Kyrpides N.,
RA   Lykidis A., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate +
CC         ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-
CC         ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) +
CC         phosphate; Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58443, ChEBI:CHEBI:77657, ChEBI:CHEBI:456216;
CC         EC=6.3.2.6; Evidence={ECO:0000256|HAMAP-Rule:MF_00137,
CC         ECO:0000256|SAAS:SAAS01117176};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00194440}.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00137, ECO:0000256|SAAS:SAAS00535425}.
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DR   EMBL; CP000283; ABE37390.1; -; Genomic_DNA.
DR   RefSeq; WP_011500583.1; NC_007958.1.
DR   STRING; 316057.RPD_0150; -.
DR   EnsemblBacteria; ABE37390; ABE37390; RPD_0150.
DR   KEGG; rpd:RPD_0150; -.
DR   eggNOG; ENOG4105C8V; Bacteria.
DR   eggNOG; COG0152; LUCA.
DR   HOGENOM; HOG000230360; -.
DR   KO; K01923; -.
DR   OMA; EMVIRGY; -.
DR   OrthoDB; 1345271at2; -.
DR   BioCyc; RPAL316057:RPD_RS00755-MONOMER; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000001818; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR001636; SAICAR_synth.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13EU9.
DR   SWISS-2DPAGE; Q13EU9.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194460};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001818};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194461, ECO:0000313|EMBL:ABE37390.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194457};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00137,
KW   ECO:0000256|SAAS:SAAS00194459}.
FT   DOMAIN       14    266       SAICAR_synt. {ECO:0000259|Pfam:PF01259}.
SQ   SEQUENCE   305 AA;  33486 MW;  69B174697D1E75FA CRC64;
     MTTMLTSDLP LNKIGRGKVR DIYAVDDERL LLVTTDRISA FDVVMAETIP MKGAVLTQIS
     AWWFDQLGGV VPHHMISADA AEIIDAVPAL KDHRAALAGR AMLCRRTTVF PIECVIRGYI
     TGSAWKEYAA SGTLAGETLP AGLQESERLA PPIFSPATKA ETGHDENITI ARMREIVGDE
     TAYTLESMTR AVYTQGEAIA REQGIIIADT KFEFGRDANG RIILIDEVMT PDSSRFWAAD
     SYAPGRSQPS FDKQPLRDYL DAERRAGRWN GEAPPPKLPA EVVAATSARY LDAYRRLTGT
     DLVVK
//

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