(data stored in SCRATCH zone)

SWISSPROT: Q13GN0_PARXL

ID   Q13GN0_PARXL            Unreviewed;       298 AA.
AC   Q13GN0;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   11-DEC-2019, entry version 86.
DE   SubName: Full=Heavy metal efflux pump, CDF family {ECO:0000313|EMBL:ABE31828.1};
DE   SubName: Full=Heavy metal/H+ antiporter, CDF family {ECO:0000313|EMBL:ABE36759.1};
GN   ORFNames=Bxe_A1104 {ECO:0000313|EMBL:ABE31842.1}, Bxe_A1118
GN   {ECO:0000313|EMBL:ABE31828.1}, Bxe_A2903
GN   {ECO:0000313|EMBL:ABE30073.1}, Bxe_B1605
GN   {ECO:0000313|EMBL:ABE34359.1}, Bxe_B2911
GN   {ECO:0000313|EMBL:ABE33084.1}, Bxe_C0391
GN   {ECO:0000313|EMBL:ABE36298.1}, Bxe_C0883
GN   {ECO:0000313|EMBL:ABE36759.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36759.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE36759.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36759.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
RN   [2] {ECO:0000313|EMBL:ABE30073.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE30073.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Chromosome 1 of Burkholderia xenovorans LB400.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ABE33084.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33084.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Chromosome 2 of Burkholderia xenovorans LB400.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ABE36759.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE36759.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of Chromosome 3 of Burkholderia xenovorans LB400.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00280}.
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DR   EMBL; CP000270; ABE30073.1; -; Genomic_DNA.
DR   EMBL; CP000270; ABE31828.1; -; Genomic_DNA.
DR   EMBL; CP000270; ABE31842.1; -; Genomic_DNA.
DR   EMBL; CP000271; ABE33084.1; -; Genomic_DNA.
DR   EMBL; CP000271; ABE34359.1; -; Genomic_DNA.
DR   EMBL; CP000272; ABE36298.1; -; Genomic_DNA.
DR   EMBL; CP000272; ABE36759.1; -; Genomic_DNA.
DR   RefSeq; WP_004574643.1; NZ_CP008762.1.
DR   STRING; 266265.Bxe_C0883; -.
DR   EnsemblBacteria; ABE30073; ABE30073; Bxe_A2903.
DR   EnsemblBacteria; ABE31828; ABE31828; Bxe_A1118.
DR   EnsemblBacteria; ABE31842; ABE31842; Bxe_A1104.
DR   EnsemblBacteria; ABE33084; ABE33084; Bxe_B2911.
DR   EnsemblBacteria; ABE34359; ABE34359; Bxe_B1605.
DR   EnsemblBacteria; ABE36298; ABE36298; Bxe_C0391.
DR   EnsemblBacteria; ABE36759; ABE36759; Bxe_C0883.
DR   GeneID; 4010396; -.
DR   KEGG; bxb:DR64_3268; -.
DR   KEGG; bxb:DR64_3282; -.
DR   KEGG; bxb:DR64_585; -.
DR   KEGG; bxb:DR64_6908; -.
DR   KEGG; bxb:DR64_7566; -.
DR   KEGG; bxb:DR64_8051; -.
DR   KEGG; bxb:DR64_853; -.
DR   KEGG; bxe:Bxe_A1104; -.
DR   KEGG; bxe:Bxe_A1118; -.
DR   KEGG; bxe:Bxe_A2903; -.
DR   KEGG; bxe:Bxe_B1605; -.
DR   KEGG; bxe:Bxe_B2911; -.
DR   KEGG; bxe:Bxe_C0391; -.
DR   KEGG; bxe:Bxe_C0883; -.
DR   eggNOG; ENOG4105D04; Bacteria.
DR   eggNOG; COG1230; LUCA.
DR   HOGENOM; HOG000002625; -.
DR   OMA; EPESLMM; -.
DR   OrthoDB; 948593at2; -.
DR   BioCyc; BXEN266265:BXE_RS07610-MONOMER; -.
DR   BioCyc; BXEN266265:BXE_RS16365-MONOMER; -.
DR   BioCyc; BXEN266265:BXE_RS16430-MONOMER; -.
DR   BioCyc; BXEN266265:BXE_RS22645-MONOMER; -.
DR   BioCyc; BXEN266265:BXE_RS29080-MONOMER; -.
DR   BioCyc; BXEN266265:BXE_RS38535-MONOMER; -.
DR   BioCyc; BXEN266265:BXE_RS40855-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0030001; P:metal ion transport; IEA:InterPro.
DR   CDD; cd00371; HMA; 1.
DR   Gene3D; 1.20.1510.10; -; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF161111; SSF161111; 1.
DR   SUPFAM; SSF55008; SSF55008; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   4: Predicted;
DR   PRODOM; Q13GN0.
DR   SWISS-2DPAGE; Q13GN0.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        125..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..95
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   298 AA;  31194 MW;  42FC9444CDF07538 CRC64;
     MSKSCGGACG GDATSAADTD IQASSEAPGR WVSVYAVPKM DCPSEERMIR LALNGFEEIR
     ALSFDLSNRR LKVVHDGEVE PVTSKLKTLG LGASLQETVA ANPETIKAAE FSAASAKQES
     GTLRWLLGIN ALLFVVEMTA GLIAQSTGLI GESLDNFADA AVYGLALYAV GHSVKMQVRA
     AHLAGVLQLI LAVGVLVEVV RRFVFGSEPE SLVMMAIAFV ALIANTSCLL LISKHREGGA
     HMKASWIFSA NDVVINLGVI TAGALVAWTG SNYPDLIIGT IAGGIVLNGA RRILALKG
//

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