(data stored in SCRATCH zone)

SWISSPROT: Q13QW6_PARXL

ID   Q13QW6_PARXL            Unreviewed;       250 AA.
AC   Q13QW6;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   07-JUN-2017, entry version 72.
DE   RecName: Full=Pyrroloquinoline-quinone synthase {ECO:0000256|HAMAP-Rule:MF_00654};
DE            EC=1.3.3.11 {ECO:0000256|HAMAP-Rule:MF_00654};
DE   AltName: Full=Coenzyme PQQ synthesis protein C {ECO:0000256|HAMAP-Rule:MF_00654};
DE   AltName: Full=Pyrroloquinoline quinone biosynthesis protein C {ECO:0000256|HAMAP-Rule:MF_00654};
GN   Name=pqqC {ECO:0000256|HAMAP-Rule:MF_00654,
GN   ECO:0000313|EMBL:ABE33523.1};
GN   ORFNames=Bxe_B2468 {ECO:0000313|EMBL:ABE33523.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33523.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE33523.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE33523.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-
CC       amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-
CC       7,9-dicarboxylic-acid to PQQ. {ECO:0000256|HAMAP-Rule:MF_00654}.
CC   -!- CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-
CC       1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 4,5-
CC       dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate
CC       + 2 H(2)O(2) + 2 H(2)O. {ECO:0000256|HAMAP-Rule:MF_00654}.
CC   -!- PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_00654}.
CC   -!- SIMILARITY: Belongs to the PqqC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00654}.
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DR   EMBL; CP000271; ABE33523.1; -; Genomic_DNA.
DR   RefSeq; WP_011490889.1; NZ_CP008762.1.
DR   ProteinModelPortal; Q13QW6; -.
DR   STRING; 266265.Bxe_B2468; -.
DR   EnsemblBacteria; ABE33523; ABE33523; Bxe_B2468.
DR   GeneID; 4007036; -.
DR   KEGG; bxb:DR64_4795; -.
DR   KEGG; bxe:Bxe_B2468; -.
DR   PATRIC; fig|266265.5.peg.5241; -.
DR   eggNOG; ENOG41086XE; Bacteria.
DR   eggNOG; COG5424; LUCA.
DR   HOGENOM; HOG000217947; -.
DR   KO; K06137; -.
DR   OMA; YYQISIP; -.
DR   OrthoDB; POG091H0KR9; -.
DR   UniPathway; UPA00539; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0033732; F:pyrroloquinoline-quinone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.20.910.10; -; 1.
DR   HAMAP; MF_00654; PQQ_syn_PqqC; 1.
DR   InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR   InterPro; IPR011845; PQQ_synth_PqqC.
DR   InterPro; IPR004305; Thiaminase-2/PQQC.
DR   Pfam; PF03070; TENA_THI-4; 1.
DR   SUPFAM; SSF48613; SSF48613; 1.
DR   TIGRFAMs; TIGR02111; PQQ_syn_pqqC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q13QW6.
DR   SWISS-2DPAGE; Q13QW6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00654};
KW   PQQ biosynthesis {ECO:0000256|HAMAP-Rule:MF_00654};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       33    242       TENA_THI-4. {ECO:0000259|Pfam:PF03070}.
SQ   SEQUENCE   250 AA;  28737 MW;  6C568576D54513AB CRC64;
     MNAKDTLGTA PRQNAQTNGG DERPAWTREE FEAQLRAKGA AYHIHHPFNV KMNSGGCSRE
     QIRGWVANRF YYQINIPLKD AAVLSNCPDR ETRRRWVLRI LDHDGCGDEE GGIETWARLG
     DAVGLSRDDL WSLKQVAPGV RFAVDAYVNF ARRAPWQESV CSSLTEMFAP QVHRDRLASW
     PEHYPWIESS GLAYFRSRIS LAQRDVEHGL AVTLDHFTRR EQQERALEIL QFKLDILWTM
     LDSIEKAFPQ
//

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