(data stored in SCRATCH zone)

SWISSPROT: Q144P4_PARXL

ID   Q144P4_PARXL            Unreviewed;       350 AA.
AC   Q144P4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 89.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   ORFNames=Bxe_A3803 {ECO:0000313|EMBL:ABE29195.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE29195.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE29195.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE29195.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-
CC         glucose + H2O; Xref=Rhea:RHEA:17221, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:57477, ChEBI:CHEBI:57649; EC=4.2.1.46;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|RuleBase:RU004473}.
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DR   EMBL; CP000270; ABE29195.1; -; Genomic_DNA.
DR   RefSeq; WP_011486991.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A3803; -.
DR   EnsemblBacteria; ABE29195; ABE29195; Bxe_A3803.
DR   GeneID; 4002583; -.
DR   KEGG; bxb:DR64_1480; -.
DR   KEGG; bxe:Bxe_A3803; -.
DR   PATRIC; fig|266265.5.peg.686; -.
DR   eggNOG; ENOG4105C1B; Bacteria.
DR   eggNOG; COG1088; LUCA.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OMA; KLIPLMC; -.
DR   OrthoDB; 707977at2; -.
DR   BioCyc; BXEN266265:BXE_RS03245-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   CDD; cd05246; dTDP_GD_SDR_e; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q144P4.
DR   SWISS-2DPAGE; Q144P4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Lyase {ECO:0000256|RuleBase:RU004473, ECO:0000313|EMBL:ABE29195.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        3    322       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   350 AA;  38764 MW;  27633FB49A408EFC CRC64;
     MILVTGGAGF IGANFVLDWL NASDEAVLNV DKLTYAGNLG TLKSQQGNPK HVFVRADICD
     RSALDALFAE HKPRAVLHFA AESHVDRSIH GPADFVQTNV VGTFTLLEAT RQYWNALGEA
     GKAAFRFLHV STDEVFGSLS ATDPQFSETT PYAPNSPYSA TKAGSDHLVR AYHHTYGLPV
     LTTNCSNNYG PYQFPEKLIP LMIANALAGK ALPVYGDGQN VRDWLYVGDH CSAIREVLAR
     GTPGETYNVG GWNEKKNLEV VHTLCDLLDQ LRPKAGGSYH DQITYVKDRP GHDRRYAIDA
     RKLERELGWK PAETFETGLA KTVQWYLDNQ AWSDEVASGE YRKWVAKQYA
//

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