SWISSPROT: Q144Z1_PARXL

ID   Q144Z1_PARXL            Unreviewed;       436 AA.
AC   Q144Z1;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 74.
DE   SubName: Full=Fumarylacetoacetate hydrolase {ECO:0000313|EMBL:ABE29098.1};
DE            EC=3.7.1.2 {ECO:0000313|EMBL:ABE29098.1};
GN   ORFNames=Bxe_A3899 {ECO:0000313|EMBL:ABE29098.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE29098.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE29098.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE29098.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
RN   [2] {ECO:0000213|PDB:5TI1}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
RA   Seattle Structural Genomics Center for Infectious Disease.,
RA   Delker S.L., Abendroth J., Lorimer D., Edwards T.E.;
RT   "Crystal Structure of Fumarylacetoacetate hydrolase from Burkholderia
RT   xenovorans LB400.";
RL   Submitted (SEP-2016) to the PDB data bank.
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DR   EMBL; CP000270; ABE29098.1; -; Genomic_DNA.
DR   RefSeq; WP_011486916.1; NZ_CP008760.1.
DR   PDB; 5TI1; X-ray; 2.00 A; A/B/C/D/E/F/G/H=1-436.
DR   PDBsum; 5TI1; -.
DR   SMR; Q144Z1; -.
DR   STRING; 266265.Bxe_A3899; -.
DR   EnsemblBacteria; ABE29098; ABE29098; Bxe_A3899.
DR   GeneID; 4002564; -.
DR   KEGG; bxb:DR64_1575; -.
DR   KEGG; bxe:Bxe_A3899; -.
DR   PATRIC; fig|266265.5.peg.585; -.
DR   eggNOG; ENOG4105E0N; Bacteria.
DR   eggNOG; COG0179; LUCA.
DR   HOGENOM; HOG000256845; -.
DR   KO; K01555; -.
DR   OMA; PNWLHIP; -.
DR   OrthoDB; 819833at2; -.
DR   BioCyc; BXEN266265:BXE_RS02780-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR   Gene3D; 2.30.30.230; -; 1.
DR   Gene3D; 3.90.850.10; -; 1.
DR   InterPro; IPR005959; Fumarylacetoacetase.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   InterPro; IPR015377; Fumarylacetoacetase_N.
DR   InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR   PANTHER; PTHR43069; PTHR43069; 1.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   Pfam; PF09298; FAA_hydrolase_N; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
DR   SUPFAM; SSF63433; SSF63433; 1.
DR   TIGRFAMs; TIGR01266; fum_ac_acetase; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q144Z1.
DR   SWISS-2DPAGE; Q144Z1.
KW   3D-structure {ECO:0000213|PDB:5TI1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Hydrolase {ECO:0000313|EMBL:ABE29098.1};
KW   Magnesium {ECO:0000213|PDB:5TI1};
KW   Metal-binding {ECO:0000213|PDB:5TI1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN       32    137       FAA_hydrolase_N. {ECO:0000259|Pfam:
FT                                PF09298}.
FT   DOMAIN      143    428       FAA_hydrolase. {ECO:0000259|Pfam:
FT                                PF01557}.
FT   METAL       145    145       Magnesium. {ECO:0000213|PDB:5TI1}.
FT   METAL       218    218       Magnesium. {ECO:0000213|PDB:5TI1}.
FT   METAL       220    220       Magnesium. {ECO:0000213|PDB:5TI1}.
FT   METAL       252    252       Magnesium. {ECO:0000213|PDB:5TI1}.
SQ   SEQUENCE   436 AA;  47440 MW;  AC3D41C93F56096C CRC64;
     MNASSDLQAT LDPSRKSWVE SANNPTGDFS IQNLPFGIFS DGLNATRRVG VAIGDSIVDL
     AALESAGLLS VPSTGAGDSV FVRDALNDFI ALGRDAWRSV RVQLSRLLSR DDATLRDDAE
     LRGRALIRQA DAQLHLPVQI PGYTDFYSSK EHATNVGSMF RDPKNALLPN WSEMPIGYNG
     RASSVVVSGT PVRRPNGQLK LPDQERPVFG ACRKLDIELE TGFVIGAGNA LGEPVTCADA
     EAHIFGMVLL NDWSARDIQQ WEYVPLGPFN AKTFATTISP WIVTLDALEP FRVAQPAQDP
     QPLAYLRHDG EHAFDITLEV TLRPQQAKEA STITRTNFKH MYWTMAQQLA HHTVSGCNTR
     VGDLMGSGTI SGPTEDSFGS LLELTWNGKK PLELREGGTR SFIEDGDELT LAGWCQGEGY
     RVGFGVCAGE ILPALK
//