(data stored in SCRATCH zone)

SWISSPROT: Q145H6_PARXL

ID   Q145H6_PARXL            Unreviewed;       484 AA.
AC   Q145H6;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 90.
DE   RecName: Full=Catalase {ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|RuleBase:RU000498};
GN   ORFNames=Bxe_A3986 {ECO:0000313|EMBL:ABE29013.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE29013.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE29013.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE29013.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240;
CC         EC=1.11.1.6; Evidence={ECO:0000256|RuleBase:RU000498};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRSR:PIRSR038928-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|RuleBase:RU000498}.
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DR   EMBL; CP000270; ABE29013.1; -; Genomic_DNA.
DR   RefSeq; WP_011486836.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A3986; -.
DR   EnsemblBacteria; ABE29013; ABE29013; Bxe_A3986.
DR   GeneID; 4002089; -.
DR   KEGG; bxb:DR64_1662; -.
DR   KEGG; bxe:Bxe_A3986; -.
DR   PATRIC; fig|266265.5.peg.503; -.
DR   eggNOG; ENOG4105CH6; Bacteria.
DR   eggNOG; COG0753; LUCA.
DR   HOGENOM; HOG000087852; -.
DR   KO; K03781; -.
DR   OMA; HADFGRM; -.
DR   OrthoDB; 1584770at2; -.
DR   BioCyc; BXEN266265:BXE_RS02380-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd08156; catalase_clade_3; 1.
DR   Gene3D; 2.40.180.10; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR040333; Catalase_3.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR037060; Catalase_core_sf.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; PTHR11465; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q145H6.
DR   SWISS-2DPAGE; Q145H6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Heme {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR038928-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000498,
KW   ECO:0000313|EMBL:ABE29013.1};
KW   Peroxidase {ECO:0000256|RuleBase:RU000498,
KW   ECO:0000313|EMBL:ABE29013.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        7    392       Catalase. {ECO:0000259|SMART:SM01060}.
FT   ACT_SITE     54     54       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   ACT_SITE    127    127       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   METAL       337    337       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038928-2}.
SQ   SEQUENCE   484 AA;  54558 MW;  25AFF1A2963784F1 CRC64;
     MSEHKLTNAA GAPVADNQNS MTAGARGPVV LQDVWLLEKL AHFDREVIPE RRVHAKGSGA
     FGTLKVTHDI SRYTKAKVFA QAGKETPLFM RFSTVAGERG AADAERDVRG FSIKFYTEEG
     NWDVVGNNTP VFFIRDPLKF PDFIHTQKRD PYTNMRSNVA AWDFWSRHPE SLHQVTILMS
     DRGIPQNFRQ MHGFGSHTYS FINANNERFW VKFHFKSMQG VENFTDAEAA QVVAQDRESA
     QRDLLTNIDQ GNFPKWRFAI QVMPEAEAAT YRFNPFDITK VWSQKDYPLI DVGTIELNRN
     AANYFADVEQ AAFTPANVVP GIGFSPDRLL QGRLFSYGDT QRYRLGVNHH QIPVNASRVA
     SPHSFHRDGA MRTDGNLGGN VNYEPNRFGD FAQDANASEP PLAAGAVDRY DHRLDDDYYT
     QPGMLFALFD AAQRERLFGN IARHINGVPQ EIVARQIEHF RRADPAYAEG VIAAIARLAE
     GETK
//

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