SWISSPROT: Q145M7_PARXL

ID   Q145M7_PARXL            Unreviewed;       811 AA.
AC   Q145M7;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 90.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ABE28962.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:ABE28962.1};
GN   ORFNames=Bxe_A4037 {ECO:0000313|EMBL:ABE28962.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28962.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28962.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28962.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; CP000270; ABE28962.1; -; Genomic_DNA.
DR   RefSeq; WP_011486788.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4037; -.
DR   EnsemblBacteria; ABE28962; ABE28962; Bxe_A4037.
DR   GeneID; 4004325; -.
DR   KEGG; bxb:DR64_1714; -.
DR   KEGG; bxe:Bxe_A4037; -.
DR   PATRIC; fig|266265.5.peg.447; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1024; LUCA.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000264370; -.
DR   KO; K07516; -.
DR   OMA; GQGFYKK; -.
DR   OrthoDB; 82358at2; -.
DR   BioCyc; BXEN266265:BXE_RS02125-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
DR   PRODOM; Q145M7.
DR   SWISS-2DPAGE; Q145M7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296,
KW   ECO:0000313|EMBL:ABE28962.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN        8    191       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      194    293       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   811 AA;  87557 MW;  D56B95EA572E3FA3 CRC64;
     MSNLIIRKVA VLGAGVMGAQ IAAHLINAKV PVLLFDLPAK EGPKNAIALK AIENLKKLSP
     APFGVKDDAQ YVQPANYDDD IGKLAECDLV IEAIAERMDW KHDLYRKVAP HLAPNAIFAT
     NTSGLSITAL SEGFPDELKA RFCGVHFFNP PRYMHLVELI PTATTRPEIL DQLESFLTSV
     VGKGVVRAKD TPNFIANRVG IFSILAVVTE AAKYGLRFDE VDDLTGARLG RAKSATFRTA
     DVVGLDTMAH VIKTMQDTLK DDPFYPVYET PAVLAELVKK GALGQKTGGG FYRKEGKAIK
     VLDAKTGEYV DGGAKADELV GRILKRPPAE RLKLLRESEH PQAQFLWAIF RDVYHYIGVH
     LESIADNARD VDLAIRWGFG WNEGPFEGWQ TAGWKQVAEW VQEDIAAGKA LSNAPLPSWV
     LEGPVAEKGG VHTNEGSWSP ASKTFVPRSS LSVYDKQVFR APLVGETAAD PKTYGKTLFE
     TDAVRAWVDD RAGENDVLIV SFKSKMNTIG PSVIDGLTQA IELAEKDYKG LVVWQPTSLK
     LGTPGGPFSA GANLEEAMPA FMMGGAKGIE PFVKKFQQGM LRVKYASVPV ISAVSGIALG
     GGCELALHSA KRVAHIESYL GLVEVGVGLV PAGGGLKEAA LRAAEAATQV GATNDLLKFV
     QKSFENAAMA KVSASALDAR AMGYLKPSDT IVFNVFELLD VAKKEARALS AAGYRPPLRV
     TQVPVAGRSA IATIKASLVN MRDGRFISEH DFLIASRIAE AVCGGDVEAG SLVDEEWLLQ
     LERRAFVDLL GTQKTQERIM GMLQTGKPVR N
//