(data stored in SCRATCH zone)

SWISSPROT: Q146A9_PARXL

ID   Q146A9_PARXL            Unreviewed;       537 AA.
AC   Q146A9;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 94.
DE   RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU363061};
DE            EC=1.9.3.1 {ECO:0000256|RuleBase:RU363061};
GN   ORFNames=Bxe_A4170 {ECO:0000313|EMBL:ABE28830.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28830.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28830.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28830.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B. {ECO:0000256|RuleBase:RU363061}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 [Fe(II)cytochrome c] + 4 H(+) + O2 = 4
CC         [Fe(III)cytochrome c] + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA-
CC         COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=1.9.3.1;
CC         Evidence={ECO:0000256|RuleBase:RU363061};
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000256|RuleBase:RU363061}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363061}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363061}.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC       {ECO:0000256|RuleBase:RU363061}.
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DR   EMBL; CP000270; ABE28830.1; -; Genomic_DNA.
DR   RefSeq; WP_007179457.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4170; -.
DR   EnsemblBacteria; ABE28830; ABE28830; Bxe_A4170.
DR   GeneID; 4001868; -.
DR   KEGG; bxb:DR64_1848; -.
DR   KEGG; bxe:Bxe_A4170; -.
DR   eggNOG; ENOG4105BZ9; Bacteria.
DR   eggNOG; COG0843; LUCA.
DR   HOGENOM; HOG000085274; -.
DR   KO; K02274; -.
DR   OMA; PVDFQYH; -.
DR   OrthoDB; 316745at2; -.
DR   BioCyc; BXEN266265:BXE_RS01450-MONOMER; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0015990; P:electron transport coupled proton transport; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd01663; Cyt_c_Oxidase_I; 1.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR   InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR   InterPro; IPR000883; Cyt_C_Oxase_1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR033944; Cyt_c_oxase_su1_dom.
DR   InterPro; IPR014241; Cyt_c_oxidase_su1_bac.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   TIGRFAMs; TIGR02891; CtaD_CoxA; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q146A9.
DR   SWISS-2DPAGE; Q146A9.
KW   Cell membrane {ECO:0000256|RuleBase:RU363061};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Copper {ECO:0000256|RuleBase:RU363061};
KW   Electron transport {ECO:0000256|RuleBase:RU363061};
KW   Heme {ECO:0000256|RuleBase:RU363061};
KW   Iron {ECO:0000256|RuleBase:RU363061};
KW   Membrane {ECO:0000256|RuleBase:RU363061};
KW   Metal-binding {ECO:0000256|RuleBase:RU363061};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363061,
KW   ECO:0000313|EMBL:ABE28830.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Respiratory chain {ECO:0000256|RuleBase:RU363061};
KW   Transmembrane {ECO:0000256|RuleBase:RU363061};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363061};
KW   Transport {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM     42     63       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM     83    104       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    125    154       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    166    192       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    204    232       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    264    282       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    294    313       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    325    345       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    357    379       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    391    416       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    432    453       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   TRANSMEM    473    497       Helical. {ECO:0000256|RuleBase:RU363061}.
FT   DOMAIN       21    537       COX1. {ECO:0000259|PROSITE:PS50855}.
SQ   SEQUENCE   537 AA;  59629 MW;  89D09CB7EAD55A9C CRC64;
     MSSIGHDVVA GHEHVHGDHA HETPHGWRRW LFATNHKDIG TLYLIFSFTM FLSGGVMALM
     IRAELFEPGL QIMRPEFFNQ LTTMHGLIMV FGAIMPAFVG FANWMVPLQI GASDMAFARM
     NNFSFWLLPV AAVLLVGSFF APGGATAAGW TLYAPLSTQM GPGMDFAIFA VHLMGASSIM
     GGINIVVTIL NMRAPGLTLM KMPMFVWTWL ITAYLLIAVM PVLAGAITMV LFDRHFGTSF
     FNAAGGGDPV MYQHIFWFFG HPEVYIMILP AFGIVSQVIP AFARKPLFGY SSMVYATSSI
     AILSFMVWAH HMFATGMPVT GQLFFMYATM LIAVPTGVKV FNWVATMWRG SLSFETPMLF
     AVGFLLVFTF GGLSGLMLAM APLDIQYHGT YFVVAHFHYV LVAGSLFALF AGWYYWAPKW
     TGWMYNETRG KIHFWASMFF FNLAFLPMHF VGLAGMPRRY ADYPAQFTDW NQVITIGAFG
     FGLAQVYFLF AVALPAYRGG GELEKAGDKP WDGATGLEWT VPSPAPFHTF ENPPTVE
//

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