(data stored in SCRATCH zone)

SWISSPROT: Q146H9_PARXL

ID   Q146H9_PARXL            Unreviewed;       359 AA.
AC   Q146H9;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   10-APR-2019, entry version 76.
DE   SubName: Full=Methionine synthase (B12-dependent) {ECO:0000313|EMBL:ABE28760.1};
DE            EC=2.1.1.13 {ECO:0000313|EMBL:ABE28760.1};
GN   ORFNames=Bxe_A4240 {ECO:0000313|EMBL:ABE28760.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE28760.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE28760.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE28760.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037505-2};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR037505-
CC       2};
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DR   EMBL; CP000270; ABE28760.1; -; Genomic_DNA.
DR   RefSeq; WP_011486602.1; NZ_CP008760.1.
DR   STRING; 266265.Bxe_A4240; -.
DR   EnsemblBacteria; ABE28760; ABE28760; Bxe_A4240.
DR   GeneID; 4004026; -.
DR   KEGG; bxb:DR64_1916; -.
DR   KEGG; bxe:Bxe_A4240; -.
DR   PATRIC; fig|266265.5.peg.234; -.
DR   eggNOG; ENOG4105C3R; Bacteria.
DR   eggNOG; COG0646; LUCA.
DR   HOGENOM; HOG000265279; -.
DR   KO; K00548; -.
DR   OMA; AQEDYKM; -.
DR   OrthoDB; 1149455at2; -.
DR   BioCyc; BXEN266265:BXE_RS01105-MONOMER; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0047150; F:betaine-homocysteine S-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008705; F:methionine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.20.20.330; -; 1.
DR   InterPro; IPR017226; Betaine-hCys_S-MeTrfase_BHMT.
DR   InterPro; IPR003726; HCY_dom.
DR   InterPro; IPR036589; HCY_dom_sf.
DR   Pfam; PF02574; S-methyl_trans; 1.
DR   PIRSF; PIRSF037505; Betaine_HMT; 2.
DR   SUPFAM; SSF82282; SSF82282; 1.
DR   PROSITE; PS50970; HCY; 1.
PE   4: Predicted;
DR   PRODOM; Q146H9.
DR   SWISS-2DPAGE; Q146H9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001817};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00333,
KW   ECO:0000313|EMBL:ABE28760.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00333,
KW   ECO:0000313|EMBL:ABE28760.1};
KW   Zinc {ECO:0000256|PIRSR:PIRSR037505-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00333}.
FT   DOMAIN       20    340       Hcy-binding. {ECO:0000259|PROSITE:
FT                                PS50970}.
FT   METAL       260    260       Zinc. {ECO:0000256|PIRSR:PIRSR037505-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00333}.
FT   METAL       325    325       Zinc. {ECO:0000256|PIRSR:PIRSR037505-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00333}.
FT   METAL       326    326       Zinc. {ECO:0000256|PIRSR:PIRSR037505-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00333}.
SQ   SEQUENCE   359 AA;  38582 MW;  DACCDEECAEA4410C CRC64;
     MNQPAQTATP VRPDAAYTRG AALPALLKSR ILILDGAMGT MIQRYKLDEA RYRGERFKDY
     GRDIKGNNEL LSITQPQIIS EIHEQYLAAG ADIVETNTFG ATTVAQADYG MEALAVEMNL
     ESAKLARAAC DKYSTPDKPR FVAGAIGPTP KTASISPDVN DPGARNVTFD ELRAAYYEQA
     RALLDGGVDL FLVETIFDTL NAKAALFALD ELFEDTGERL PIMISGTVTD ASGRILSGQT
     VEAFWNSLRH AKPLTFGLNC ALGAALMRPY IAELAKLCDT YVSCYPNAGL PNPMSDTGFD
     ELPADTSGLL KEFAQAGLVN IAGGCCGTTP EHIAAIAQAL AGVKPRVWAN YRETDTETV
//

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