(data stored in ACNUC23442 zone)

SWISSPROT: Q173V2_AEDAE

ID   Q173V2_AEDAE            Unreviewed;       124 AA.
AC   Q173V2;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   30-AUG-2017, entry version 95.
DE   RecName: Full=Histone H2A {ECO:0000256|RuleBase:RU003767};
GN   Name=5568655 {ECO:0000313|VectorBase:AAEL000494-PA,
GN   ECO:0000313|VectorBase:AAEL000497-PA,
GN   ECO:0000313|VectorBase:AAEL000518-PA,
GN   ECO:0000313|VectorBase:AAEL000525-PA,
GN   ECO:0000313|VectorBase:AAEL003818-PA,
GN   ECO:0000313|VectorBase:AAEL003826-PA,
GN   ECO:0000313|VectorBase:AAEL003851-PA,
GN   ECO:0000313|VectorBase:AAEL003862-PA,
GN   ECO:0000313|VectorBase:AAEL007005-PA};
GN   ORFNames=AAEL000494 {ECO:0000313|EMBL:EAT48480.1}, AAEL000497
GN   {ECO:0000313|EMBL:EAT48488.1}, AAEL000518
GN   {ECO:0000313|EMBL:EAT48476.1}, AAEL000525
GN   {ECO:0000313|EMBL:EAT48484.1}, AAEL003818
GN   {ECO:0000313|EMBL:EAT44808.1}, AAEL003826
GN   {ECO:0000313|EMBL:EAT44811.1}, AAEL003851
GN   {ECO:0000313|EMBL:EAT44815.1}, AAEL003862
GN   {ECO:0000313|EMBL:EAT44822.1}, AAEL007005
GN   {ECO:0000313|EMBL:EAT41344.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT41344.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT41344.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT41344.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT41344.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL000494-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT41344.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL000494-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT41344.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT41344.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL000494-PA, ECO:0000313|VectorBase:AAEL000497-PA, ECO:0000313|VectorBase:AAEL000518-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL000494-PA,
RC   ECO:0000313|VectorBase:AAEL000497-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two
CC       molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4
CC       heterotetramer and two H2A-H2B heterodimers. The octamer wraps
CC       approximately 147 bp of DNA. {ECO:0000256|RuleBase:RU003767,
CC       ECO:0000256|SAAS:SAAS00329320}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00534031}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003767,
CC       ECO:0000256|SAAS:SAAS00534029}.
CC   -!- SIMILARITY: Belongs to the histone H2A family.
CC       {ECO:0000256|RuleBase:RU003767, ECO:0000256|SAAS:SAAS00534028}.
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DR   EMBL; CH477416; EAT41344.1; -; Genomic_DNA.
DR   EMBL; CH477283; EAT44808.1; -; Genomic_DNA.
DR   EMBL; CH477283; EAT44811.1; -; Genomic_DNA.
DR   EMBL; CH477283; EAT44815.1; -; Genomic_DNA.
DR   EMBL; CH477283; EAT44822.1; -; Genomic_DNA.
DR   EMBL; CH477194; EAT48476.1; -; Genomic_DNA.
DR   EMBL; CH477194; EAT48480.1; -; Genomic_DNA.
DR   EMBL; CH477194; EAT48484.1; -; Genomic_DNA.
DR   EMBL; CH477194; EAT48488.1; -; Genomic_DNA.
DR   RefSeq; XP_001652489.1; XM_001652439.1.
DR   RefSeq; XP_001656984.1; XM_001656934.1.
DR   RefSeq; XP_001656988.1; XM_001656938.1.
DR   RefSeq; XP_001656992.1; XM_001656942.1.
DR   RefSeq; XP_001656996.1; XM_001656946.1.
DR   RefSeq; XP_001657264.1; XM_001657214.1.
DR   RefSeq; XP_001657267.1; XM_001657217.1.
DR   RefSeq; XP_001657271.1; XM_001657221.1.
DR   RefSeq; XP_001657278.1; XM_001657228.1.
DR   STRING; 7159.AAEL007005-PA; -.
DR   EnsemblMetazoa; AAEL000494-RA; AAEL000494-PA; AAEL000494.
DR   EnsemblMetazoa; AAEL000497-RA; AAEL000497-PA; AAEL000497.
DR   EnsemblMetazoa; AAEL000518-RA; AAEL000518-PA; AAEL000518.
DR   EnsemblMetazoa; AAEL000525-RA; AAEL000525-PA; AAEL000525.
DR   EnsemblMetazoa; AAEL003818-RA; AAEL003818-PA; AAEL003818.
DR   EnsemblMetazoa; AAEL003826-RA; AAEL003826-PA; AAEL003826.
DR   EnsemblMetazoa; AAEL003851-RA; AAEL003851-PA; AAEL003851.
DR   EnsemblMetazoa; AAEL003862-RA; AAEL003862-PA; AAEL003862.
DR   EnsemblMetazoa; AAEL007005-RA; AAEL007005-PA; AAEL007005.
DR   GeneID; 5568655; -.
DR   GeneID; 5578461; -.
DR   GeneID; 5578465; -.
DR   GeneID; 5578469; -.
DR   GeneID; 5578473; -.
DR   GeneID; 5579068; -.
DR   GeneID; 5579071; -.
DR   GeneID; 5579084; -.
DR   GeneID; 5579128; -.
DR   KEGG; aag:AaeL_AAEL000494; -.
DR   KEGG; aag:AaeL_AAEL000497; -.
DR   KEGG; aag:AaeL_AAEL000518; -.
DR   KEGG; aag:AaeL_AAEL000525; -.
DR   KEGG; aag:AaeL_AAEL003818; -.
DR   KEGG; aag:AaeL_AAEL003826; -.
DR   KEGG; aag:AaeL_AAEL003851; -.
DR   KEGG; aag:AaeL_AAEL003862; -.
DR   KEGG; aag:AaeL_AAEL007005; -.
DR   VectorBase; AAEL000494-RA; AAEL000494-PA; AAEL000494.
DR   VectorBase; AAEL000497-RA; AAEL000497-PA; AAEL000497.
DR   VectorBase; AAEL000518-RA; AAEL000518-PA; AAEL000518.
DR   VectorBase; AAEL000525-RA; AAEL000525-PA; AAEL000525.
DR   VectorBase; AAEL003818-RA; AAEL003818-PA; AAEL003818.
DR   VectorBase; AAEL003826-RA; AAEL003826-PA; AAEL003826.
DR   VectorBase; AAEL003851-RA; AAEL003851-PA; AAEL003851.
DR   VectorBase; AAEL003862-RA; AAEL003862-PA; AAEL003862.
DR   VectorBase; AAEL007005-RA; AAEL007005-PA; AAEL007005.
DR   eggNOG; KOG1756; Eukaryota.
DR   eggNOG; COG5262; LUCA.
DR   HOGENOM; HOG000234652; -.
DR   KO; K11251; -.
DR   OMA; IMEYLCA; -.
DR   OrthoDB; EOG091G0XGD; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00620; HISTONEH2A.
DR   SMART; SM00414; H2A; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q173V2.
DR   SWISS-2DPAGE; Q173V2.
KW   Chromosome {ECO:0000256|RuleBase:RU003767,
KW   ECO:0000256|SAAS:SAAS00470872};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   DNA-binding {ECO:0000256|RuleBase:RU003767,
KW   ECO:0000256|SAAS:SAAS00470866};
KW   Nucleosome core {ECO:0000256|RuleBase:RU003767,
KW   ECO:0000256|SAAS:SAAS00470862};
KW   Nucleus {ECO:0000256|RuleBase:RU003767,
KW   ECO:0000256|SAAS:SAAS00470877};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT   DOMAIN       12     88       Histone. {ECO:0000259|Pfam:PF00125}.
FT   DOMAIN       91    124       Histone_H2A_C. {ECO:0000259|Pfam:
FT                                PF16211}.
SQ   SEQUENCE   124 AA;  13363 MW;  725BA63C393155F6 CRC64;
     MSGRGKGGKV KGKAKSRSNR AGLQFPVGRI HRLLRKGNYA ERVGAGAPVY LAAVMEYLAA
     EVLELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLSGV TIAQGGVLPN IQAVLLPKKT
     EKKA
//

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