(data stored in ACNUC5448 zone)

SWISSPROT: Q176U2_AEDAE

ID   Q176U2_AEDAE            Unreviewed;       575 AA.
AC   Q176U2;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   08-MAY-2019, entry version 83.
DE   SubName: Full=AAEL006250-PA {ECO:0000313|EMBL:EAT42194.1};
DE   SubName: Full=Insulin receptor tyrosine kinase substrate {ECO:0000313|VectorBase:AAEL006250-PA};
GN   ORFNames=AAEL006250 {ECO:0000313|EMBL:EAT42194.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT42194.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT42194.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT42194.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT42194.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL006250-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT42194.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL006250-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT42194.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT42194.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL006250-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL006250-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; CH477382; EAT42194.1; -; Genomic_DNA.
DR   RefSeq; XP_001657621.1; XM_001657571.1.
DR   STRING; 7159.AAEL006250-PA; -.
DR   VectorBase; AAEL006250-RA; AAEL006250-PA; AAEL006250.
DR   eggNOG; KOG2642; Eukaryota.
DR   eggNOG; ENOG41110CD; LUCA.
DR   HOGENOM; HOG000012882; -.
DR   InParanoid; Q176U2; -.
DR   OMA; PLWQQSC; -.
DR   PhylomeDB; Q176U2; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR013606; I-BAR_dom.
DR   InterPro; IPR027681; IRSp53/IRTKS/Pinkbar.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR14206; PTHR14206; 1.
DR   Pfam; PF08397; IMD; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS51338; IMD; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
DR   PRODOM; Q176U2.
DR   SWISS-2DPAGE; Q176U2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS00989295}.
FT   DOMAIN        1    242       IMD. {ECO:0000259|PROSITE:PS51338}.
FT   DOMAIN      328    389       SH3. {ECO:0000259|PROSITE:PS50002}.
SQ   SEQUENCE   575 AA;  64431 MW;  B68752744B4CC566 CRC64;
     MTTTMTMMVV TFTNILEKFN PGARQLISAG KAYLKALHGA SAASNLFNEA LAKIAVNAQQ
     GGTIDIGSAL MNIVGVYKEI QDQHMNILKA FYVDLLVPLE TNLEKDTKVV QFEQKKFLQQ
     HKLRSDGYTK AATTMKKYRK KNSKSSPKDA EKEIKSIQTF EEEKHKLDQF CEQSLKNAMT
     QERRRYGFVL ERQCSLAKHW MAYHHSGHMI IEKSLDNWNE VAATREFLPP NVENMFTTKQ
     LKDMDDDEDD AQSIASQLRK TRSIDASCLD MRSLGDVVNS SMMHMPRAKS EFNLNNNSNT
     STLVGGMSGG PRHSINVSVM STGDTNQWER PTVKALYAYL SSGENQLSFL EGDKIALVGD
     RAKGWQFGEN LRTQKFGWFP IAYTENEREE KESISEWVKA PPSEIEVENT PDSSLESTLV
     DDSMPPPSKS NNSNSYHDEA SPTRMFGDTI QYRQSKQFRR LSRGEKPPKP GPPPQLPAPV
     PTPVVPNYSK PQGVPQSNSF SSSGGPPMVE KRKTPSATMN FNKPQSANKP KVSRNGIASA
     SLHSSNDSGF SNELQQQQEP ELYSDDETVH RVPIR
//

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