(data stored in ACNUC31183 zone)

SWISSPROT: Q177V5_AEDAE

ID   Q177V5_AEDAE            Unreviewed;       837 AA.
AC   Q177V5;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   30-AUG-2017, entry version 64.
DE   SubName: Full=AAEL005998-PA {ECO:0000313|EMBL:EAT42470.1};
DE   SubName: Full=Rap GTPase-activating protein {ECO:0000313|VectorBase:AAEL005998-PA};
DE   Flags: Fragment;
GN   Name=5567344 {ECO:0000313|VectorBase:AAEL005998-PA};
GN   ORFNames=AAEL005998 {ECO:0000313|EMBL:EAT42470.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT42470.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT42470.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT42470.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT42470.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL005998-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT42470.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL005998-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT42470.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT42470.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL005998-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL005998-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; CH477370; EAT42470.1; -; Genomic_DNA.
DR   RefSeq; XP_001651774.1; XM_001651724.1.
DR   UniGene; Aae.10252; -.
DR   ProteinModelPortal; Q177V5; -.
DR   STRING; 7159.AAEL005998-PA; -.
DR   EnsemblMetazoa; AAEL005998-RA; AAEL005998-PA; AAEL005998.
DR   GeneID; 5567344; -.
DR   KEGG; aag:AaeL_AAEL005998; -.
DR   VectorBase; AAEL005998-RA; AAEL005998-PA; AAEL005998.
DR   eggNOG; KOG3686; Eukaryota.
DR   eggNOG; ENOG410XTIX; LUCA.
DR   HOGENOM; HOG000231640; -.
DR   InParanoid; Q177V5; -.
DR   KO; K17700; -.
DR   OMA; VANQEHM; -.
DR   OrthoDB; EOG091G028T; -.
DR   PhylomeDB; Q177V5; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR000331; Rap_GAP_dom.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; SSF111347; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
DR   PRODOM; Q177V5.
DR   SWISS-2DPAGE; Q177V5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT   DOMAIN      251    467       Rap-GAP. {ECO:0000259|PROSITE:PS50085}.
FT   NON_TER     837    837       {ECO:0000313|EMBL:EAT42470.1}.
SQ   SEQUENCE   837 AA;  90710 MW;  3424A1E368383FD6 CRC64;
     NTREERISNP HGGNNNDTPN NLTVQIPQQT RSLLRHSNSM SSNPHSNSSS TPASPHLLSN
     SSSGHLHHTL SNGGTLHHHP QYQSQSSVSS QSSSIISAVP PLQRLLEDHL SKPSPYAMIV
     IPNNGGYWVD GTDHDAGYDI PSHTTWRVGK IESDDTAKCY RRFFISREHS NLVGHDDQLG
     PVLLSIKSEN VANQDHIRIL LRLRTGTMHE IIPASCLGSN PSPIKMARLL NDQINVDSFM
     PVLCPKASTL IASYDEHVLV TNFKFGVLYQ RYGQTTEEEL FCNSDTTPAL EEFLDLLGQR
     IRLRDHKGYR GGLDIQNGHT GDTAVYEVFK EREIMFHVST LLPYTEGDPQ QLQRKRHIGN
     DIVAIVFQEE NTPFSPAMIA SHFLHAFIVV QPLEPNTPNC RYKISVTARD DVPFFGPTLP
     QPSVFKKGPE LKEFLLTKLI NAENACYKAD KFAQLELRTR TSLLQNLVDE LKEKTRDFLG
     ADLLGAPTSP TPETPKSESG FTGSRFIDTV KKALNARLRS QNSDPTNGSV ESNPKHHNSI
     KKSKEISDVP CGPGQVVNIG RSLSKSSTTG SRKSPNDSVA SSPDITSRCS LNPNNLNNNN
     NSNASNNNHH HHHHGGNGGN HHGAGAKGLS NGVSNGTGNN NNNNNGPVAM SETSDDSSLN
     SVDLDPMDAG ATYIDSDTGL ESMSSADATT KACSLCLDGD RAERSTNGGG SVISVSVGTG
     STGGDSTRDL RSSTGSGGTN VSGGGGGVTV GVAGNTGMLL VTPDVVQQMD GFKQEITRLK
     CDKLDLLRQN VTCQRDIKRL RERELSLQGD LAAAGKEILR LRDLLKEYMP SAAAEPL
//

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