(data stored in ACNUC5448 zone)

SWISSPROT: Q17LB9_AEDAE

ID   Q17LB9_AEDAE            Unreviewed;       867 AA.
AC   Q17LB9;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   08-MAY-2019, entry version 77.
DE   SubName: Full=AAEL001398-PA {ECO:0000313|EMBL:EAT47456.1};
DE   SubName: Full=Guanine nucleotide exchange factor {ECO:0000313|VectorBase:AAEL001398-PA};
DE   Flags: Fragment;
GN   ORFNames=AAEL001398 {ECO:0000313|EMBL:EAT47456.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT47456.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT47456.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47456.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT47456.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL001398-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47456.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL001398-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT47456.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT47456.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL001398-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL001398-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CH477217; EAT47456.1; -; Genomic_DNA.
DR   RefSeq; XP_001659169.1; XM_001659119.1.
DR   STRING; 7159.AAEL001398-PA; -.
DR   VectorBase; AAEL001398-RA; AAEL001398-PA; AAEL001398.
DR   eggNOG; KOG3523; Eukaryota.
DR   eggNOG; COG5422; LUCA.
DR   HOGENOM; HOG000048014; -.
DR   InParanoid; Q17LB9; -.
DR   OMA; LMWRGDD; -.
DR   PhylomeDB; Q17LB9; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
DR   PRODOM; Q17LB9.
DR   SWISS-2DPAGE; Q17LB9.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01163584}.
FT   DOMAIN      411    597       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      772    833       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   COILED      517    537       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:EAT47456.1}.
SQ   SEQUENCE   867 AA;  97232 MW;  63DFDEB31C55E4FF CRC64;
     EGIDSDSFDS DESDEDRRND TYVHSNDINS AKQLPDPPPS NNQMYALMQK IRNIGTLSKS
     ELAKGFNKFS KKKISSSKSP KIFTGENLTY PSGPDDNNAA SYENTPLPKT PKHNSDSSNV
     STFRKKSKTG KSLRSKLRKS LQSDSSLNIH SSFNASRSTF YVTDSLDVDS GIFNGSEPNS
     SSSNLNVASV GKDTASPLKL APHKTPDADR RKSMNGGSPA SRPTIPPPPP PISAPIGDKK
     FLKNRKLGAT SWYAECGVFK ADSLKQASFE NELKNKERST TSWYAEAGLY QTSDVSVASS
     SESSGVSTGG EGGGEDDHSH SMFVNEPLYQ IYNAAKLESL TRDIDAEITG DGDTELGAGS
     GSDEDVVGRK LRPSAFELIE PNVGKLRTLW CEIPEVINSE ILLTLTPTEK RLQEAKFEIL
     TSEASYLKSL NLLKTHFINH PAFRDVKVLT SSERKTLFSN IIPVQECSDR LLCDLENCWQ
     DNIMLLGLSH SIYKHAEKHF HVYVNYCEHQ AKIDRTLKNL KANKTEFTKT LLELESDPIC
     CGLSLSSFLM LPMQRITRMR LLLDAVLQRL KSDDDEFISW EKTFVLINQI LKQCNDAAHR
     SEQMYEMEMI SRQIEFPSHI RPLAIVPCGI GPPGSVMRKL EKKGELVHLL WRGDDAKLTF
     GKKFSKSSIY AFLFTDLIVL TKKKGDETYL VTDYCPRALL TVNSGDIVPQ LPTKEMQAIG
     KHLIIMTLLE NHEGKTIEMI ISCPSETERE RWLKVTEPLS SENPDEKIYE QWDCPQVVAI
     HPYQALQPDE LDLDITEVVN VHRKMADGWY EGERIRDGAV GWFPSNYTKE IPSAHVRAKH
     IKQRHVLLSY TSKYIDTTTR TLQHSKK
//

If you have problems or comments...

PBIL Back to PBIL home page