(data stored in ACNUC8465 zone)

SWISSPROT: Q17QH2_BOVIN

ID   Q17QH2_BOVIN            Unreviewed;       400 AA.
AC   Q17QH2; F1MYR6;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   11-DEC-2019, entry version 120.
DE   SubName: Full=MAP2K2 protein {ECO:0000313|EMBL:AAI18363.1};
DE   SubName: Full=Mitogen-activated protein kinase kinase 2 {ECO:0000313|Ensembl:ENSBTAP00000063221};
GN   Name=MAP2K2 {ECO:0000313|EMBL:AAI18363.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000063221, ECO:0000313|VGNC:VGNC:55215};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI18363.1};
RN   [1] {ECO:0000313|EMBL:AAI18363.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI18363.1};
RC   TISSUE=Fetal liver {ECO:0000313|EMBL:AAI18363.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000063221, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063221,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000063221}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000063221};
RG   Ensembl;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   EMBL; BC118362; AAI18363.1; -; mRNA.
DR   RefSeq; NP_001033160.2; NM_001038071.2.
DR   STRING; 9913.ENSBTAP00000011377; -.
DR   Ensembl; ENSBTAT00000081829; ENSBTAP00000063221; ENSBTAG00000024450.
DR   GeneID; 510434; -.
DR   KEGG; bta:510434; -.
DR   CTD; 5605; -.
DR   VGNC; VGNC:55215; MAP2K2.
DR   eggNOG; KOG0581; Eukaryota.
DR   eggNOG; ENOG410XQ5A; LUCA.
DR   GeneTree; ENSGT00940000153487; -.
DR   HOGENOM; HOG000234206; -.
DR   KO; K04369; -.
DR   OMA; EAWASTF; -.
DR   OrthoDB; 688282at2759; -.
DR   TreeFam; TF105137; -.
DR   Reactome; R-BTA-112411; MAPK1 (ERK2) activation.
DR   Reactome; R-BTA-170968; Frs2-mediated activation.
DR   Reactome; R-BTA-445144; Signal transduction by L1.
DR   Reactome; R-BTA-5673000; RAF activation.
DR   Reactome; R-BTA-5674135; MAP2K and MAPK activation.
DR   Reactome; R-BTA-5674499; Negative feedback regulation of MAPK pathway.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000024450; Expressed in 9 organ(s), highest expression level in skeletal muscle tissue.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q17QH2.
DR   SWISS-2DPAGE; Q17QH2.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|RuleBase:RU000304};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000256|RuleBase:RU000304}.
FT   DOMAIN          72..369
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          286..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          34..57
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   400 AA;  44502 MW;  FF7CDABD0A943BD4 CRC64;
     MLARRKPVLP ALTINPAIAE GPSPTSEGAS EAHLVDLQKK LEELELDEQQ KKRLEAFLTQ
     KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ
     VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG
     LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ
     GTHYSVQSDI WSMGLSLVEL SIGRYPIPPP DAKELEAIFG RPMVDGAEGE PPSISPRPRP
     PGRPISGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTQ DFQEFVNKCL IKNPAERADL
     KMLMNHTFIK RSEVEEVDFA GWLCKTLRLN QPSTPTRTAV
//

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