(data stored in SCRATCH zone)

SWISSPROT: Q2ILV1_ANADE

ID   Q2ILV1_ANADE            Unreviewed;       331 AA.
AC   Q2ILV1;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 94.
DE   RecName: Full=Beta-ketoacyl-[acyl-carrier-protein] synthase III {ECO:0000256|SAAS:SAAS00362920};
DE            EC=2.3.1.180 {ECO:0000256|SAAS:SAAS00362920};
GN   OrderedLocusNames=Adeh_0005 {ECO:0000313|EMBL:ABC79783.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC79783.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] +
CC         CO2 + CoA; Xref=Rhea:RHEA:12080, Rhea:RHEA-COMP:9623, Rhea:RHEA-
CC         COMP:9625, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:78449,
CC         ChEBI:CHEBI:78450; EC=2.3.1.180;
CC         Evidence={ECO:0000256|SAAS:SAAS01121373};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|SAAS:SAAS00048641}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00088601}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00088631}.
CC   -!- SIMILARITY: Belongs to the FabH family.
CC       {ECO:0000256|SAAS:SAAS00554340}.
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DR   EMBL; CP000251; ABC79783.1; -; Genomic_DNA.
DR   RefSeq; WP_011419066.1; NC_007760.1.
DR   STRING; 290397.Adeh_0005; -.
DR   EnsemblBacteria; ABC79783; ABC79783; Adeh_0005.
DR   KEGG; ade:Adeh_0005; -.
DR   eggNOG; ENOG4105CCZ; Bacteria.
DR   eggNOG; COG0332; LUCA.
DR   HOGENOM; HOG000246674; -.
DR   KO; K00648; -.
DR   OMA; QIKSGQC; -.
DR   BioCyc; ADEH290397:G1G5W-5-MONOMER; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR013751; ACP_syn_III.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004655; FabH_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF08545; ACP_syn_III; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   TIGRFAMs; TIGR00747; fabH; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2ILV1.
DR   SWISS-2DPAGE; Q2ILV1.
KW   Acyltransferase {ECO:0000256|SAAS:SAAS00440245,
KW   ECO:0000313|EMBL:ABC79783.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00048623};
KW   Fatty acid biosynthesis {ECO:0000256|SAAS:SAAS00440270};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00088611};
KW   Lipid biosynthesis {ECO:0000256|SAAS:SAAS00440289};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00440256};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00160587};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935};
KW   Transferase {ECO:0000256|SAAS:SAAS00440538,
KW   ECO:0000313|EMBL:ABC79783.1}.
FT   DOMAIN      107    188       ACP_syn_III. {ECO:0000259|Pfam:PF08545}.
FT   DOMAIN      243    331       ACP_syn_III_C. {ECO:0000259|Pfam:
FT                                PF08541}.
SQ   SEQUENCE   331 AA;  36098 MW;  0E341B832FFA2251 CRC64;
     MPRAAIVALG THVPDRVVTN EELTRHMETT DAWIQERTGI QERRWVREGT GNSDLALEAT
     KKALDKAGWK PTDIEAIVYA SLSPDHMFPG DGCFLNAKLG IPGVPAIDIR NQCTGFLYGL
     SVADAWIRTG MYRRILLVGS EVHSTGLDVT TRGRDVAVIF GDGAGAALLE ATDDPGRGVL
     SCHLHADGRF ARDLFTDAPG SIYHPRVQPR MLEDASIFPH MEGQKVFKHA VVRMPEVLKE
     AFDKNGVGPQ DLKVLVPHQA NLRIAQMVQR SLGLRDDQVF NNIQRYGNTT AASIPLALAE
     AVEARGVVRG DLVGLCAFGA GFTWASALVR W
//

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