(data stored in SCRATCH zone)

SWISSPROT: Q2ILY1_ANADE

ID   Q2ILY1_ANADE            Unreviewed;       441 AA.
AC   Q2ILY1;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 68.
DE   RecName: Full=Phenylacetate-coenzyme A ligase {ECO:0000256|PIRNR:PIRNR006444};
DE            EC=6.2.1.30 {ECO:0000256|PIRNR:PIRNR006444};
DE   AltName: Full=Phenylacetyl-CoA ligase {ECO:0000256|PIRNR:PIRNR006444};
GN   OrderedLocusNames=Adeh_0038 {ECO:0000313|EMBL:ABC79816.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC79816.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the activation of phenylacetic acid (PA) to
CC       phenylacetyl-CoA (PA-CoA). {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-phenylacetate + ATP + CoA = AMP + diphosphate +
CC         phenylacetyl-CoA; Xref=Rhea:RHEA:20956, ChEBI:CHEBI:18401,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57390, ChEBI:CHEBI:456215; EC=6.2.1.30;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006444};
CC   -!- PATHWAY: Aromatic compound metabolism; phenylacetate degradation.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
CC   -!- SIMILARITY: Belongs to the phenylacetyl-CoA ligase family.
CC       {ECO:0000256|PIRNR:PIRNR006444}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000251; ABC79816.1; -; Genomic_DNA.
DR   RefSeq; WP_011419099.1; NC_007760.1.
DR   STRING; 290397.Adeh_0038; -.
DR   EnsemblBacteria; ABC79816; ABC79816; Adeh_0038.
DR   KEGG; ade:Adeh_0038; -.
DR   eggNOG; ENOG4105DZS; Bacteria.
DR   eggNOG; COG1541; LUCA.
DR   HOGENOM; HOG000197614; -.
DR   KO; K01912; -.
DR   OMA; GSHIWED; -.
DR   BioCyc; ADEH290397:G1G5W-40-MONOMER; -.
DR   UniPathway; UPA00930; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0047475; F:phenylacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010124; P:phenylacetate catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR028154; AMP-dep_Lig_C.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; AMP-dep_Synthh-like_sf.
DR   InterPro; IPR011880; PA_CoA_ligase.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF14535; AMP-binding_C_2; 1.
DR   PIRSF; PIRSF006444; PaaK; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2ILY1.
DR   SWISS-2DPAGE; Q2ILY1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   Ligase {ECO:0000256|PIRNR:PIRNR006444, ECO:0000313|EMBL:ABC79816.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR006444};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935}.
FT   DOMAIN       98    294       AMP-binding. {ECO:0000259|Pfam:PF00501}.
FT   DOMAIN      343    439       AMP-binding_C_2. {ECO:0000259|Pfam:
FT                                PF14535}.
SQ   SEQUENCE   441 AA;  48653 MW;  8489FDF143D78228 CRC64;
     MTTSWNDAGS AFHPASAPDF LPRRELEQLQ LARLRAVVAR AYEKVPLLRQ RMEARGVFPD
     ALHALEDLAR LPFTVKADLR DTYPFGLFAS PVEEIVRLHA SSGTTGKPIV VAYTAADLEV
     WTSVMVRAFA ACGLHQGDLI QNAYGYGLFT GGLGAHYGGE ALGATVIPIS GGNTERQLMV
     LQDFGVTAIC CTPSYMVHLI ERARDAKIGF GRLKVGVFGA EPWSESMRAH IEREAGIRAH
     DIYGLSEIIG PGVGIECVHR DGLHLFEDHF YPEIVDPETG AVLPDGAEGE LVLTTLSKQA
     MPMIRYRTRD ITALDPTPCA CGRTLRRIRR IGRRSDDMFI IRGVNVFPSQ VETALLQVEG
     TLPHYQIVLT RAKGLDEMEV QVEVTPEVFS DEIRGLQRLQ EHLATALEQV LGIRAQVTLV
     APRTLQRSEG KAKRVIDRRN I
//

If you have problems or comments...

PBIL Back to PBIL home page