(data stored in SCRATCH zone)

SWISSPROT: Q2IN32_ANADE

ID   Q2IN32_ANADE            Unreviewed;       428 AA.
AC   Q2IN32;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   08-MAY-2019, entry version 79.
DE   RecName: Full=Nuclease SbcCD subunit D {ECO:0000256|RuleBase:RU363069};
GN   Name=sbcD {ECO:0000256|RuleBase:RU363069};
GN   OrderedLocusNames=Adeh_0434 {ECO:0000313|EMBL:ABC80210.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC80210.1, ECO:0000313|Proteomes:UP000001935};
RN   [1] {ECO:0000313|EMBL:ABC80210.1, ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|EMBL:ABC80210.1,
RC   ECO:0000313|Proteomes:UP000001935};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C {ECO:0000313|Proteomes:UP000001935};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C.,
RA   Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S.,
RA   Kirby J.R., Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures
CC       can inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double
CC       strand exonuclease that can open hairpins. It also has a 5'
CC       single-strand endonuclease activity.
CC       {ECO:0000256|RuleBase:RU363069}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD.
CC       {ECO:0000256|RuleBase:RU363069}.
CC   -!- SIMILARITY: Belongs to the SbcD family.
CC       {ECO:0000256|RuleBase:RU363069}.
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DR   EMBL; CP000251; ABC80210.1; -; Genomic_DNA.
DR   STRING; 290397.Adeh_0434; -.
DR   EnsemblBacteria; ABC80210; ABC80210; Adeh_0434.
DR   KEGG; ade:Adeh_0434; -.
DR   eggNOG; ENOG4107RH8; Bacteria.
DR   eggNOG; COG0420; LUCA.
DR   HOGENOM; HOG000026260; -.
DR   KO; K03547; -.
DR   OMA; TSGNHDS; -.
DR   BioCyc; ADEH290397:G1G5W-445-MONOMER; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR004593; SbcD.
DR   InterPro; IPR026843; SbcD_C.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF12320; SbcD_C; 1.
DR   TIGRFAMs; TIGR00619; sbcd; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q2IN32.
DR   SWISS-2DPAGE; Q2IN32.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001935};
KW   DNA recombination {ECO:0000256|RuleBase:RU363069};
KW   DNA replication {ECO:0000256|RuleBase:RU363069};
KW   Endonuclease {ECO:0000256|RuleBase:RU363069};
KW   Exonuclease {ECO:0000256|RuleBase:RU363069};
KW   Hydrolase {ECO:0000256|RuleBase:RU363069,
KW   ECO:0000313|EMBL:ABC80210.1};
KW   Nuclease {ECO:0000256|RuleBase:RU363069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001935}.
FT   DOMAIN       14    104       Metallophos. {ECO:0000259|Pfam:PF00149}.
FT   DOMAIN      296    400       SbcD_C. {ECO:0000259|Pfam:PF12320}.
SQ   SEQUENCE   428 AA;  45508 MW;  9660FA3F556C4C79 CRC64;
     MSDRRVSSMA SVALRILHTA DWHLGHALHG VDRGPEHERF VAWLLDTAEA EAVDAVIVAG
     DVFDAANPPA GAQALWYRFL AEAWRRLPRL QLVVVGGNHD SASRLDAVDP LLREMGRLHV
     VGGVPRGGAG APDLEKLLVP LEDAAGRRAA WVAAVPYLRA ADLGAGAADA DAAEATRRFY
     AAALERARAR RAPGEALLAT GHLYAVGGKT SELSERRLAV GNQAAVPADA FPADLAYVAL
     GHLHLAQAVG GRETVRYSGS ALPLSFGERG YRHGVVVADL DGEAVRAQRV LRVPRFVELV
     SVPDGEAPAP LPEVLAALEA LPARGEGPDA LRPLLEVKVR LERPEPALRA LLDQALAGKE
     ARLVRIATTL AGTGRALGDG ERRALGDLVP EDVFRRKYDA DYGGPPPDAL LEAFRALLQE
     VESEEGAR
//

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