(data stored in SCRATCH zone)

SWISSPROT: Q3KJE7_PSEPF

ID   Q3KJE7_PSEPF            Unreviewed;       507 AA.
AC   Q3KJE7;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 111.
DE   RecName: Full=Histidine ammonia-lyase {ECO:0000256|SAAS:SAAS00831227};
DE            EC=4.3.1.3 {ECO:0000256|SAAS:SAAS00831227};
GN   OrderedLocusNames=Pfl01_0365 {ECO:0000313|EMBL:ABA72109.1};
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA72109.1, ECO:0000313|Proteomes:UP000002704};
RN   [1] {ECO:0000313|EMBL:ABA72109.1, ECO:0000313|Proteomes:UP000002704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA72109.1,
RC   ECO:0000313|Proteomes:UP000002704};
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine = NH4(+) + trans-urocanate;
CC         Xref=Rhea:RHEA:21232, ChEBI:CHEBI:17771, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:57595; EC=4.3.1.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01124165};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC       {ECO:0000256|SAAS:SAAS00765965}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00831222}.
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
CC       {ECO:0000256|RuleBase:RU003954, ECO:0000256|SAAS:SAAS00831225}.
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DR   EMBL; CP000094; ABA72109.1; -; Genomic_DNA.
DR   RefSeq; WP_011332048.1; NC_007492.2.
DR   STRING; 205922.Pfl01_0365; -.
DR   EnsemblBacteria; ABA72109; ABA72109; Pfl01_0365.
DR   KEGG; pfo:Pfl01_0365; -.
DR   eggNOG; ENOG4105C84; Bacteria.
DR   eggNOG; COG2986; LUCA.
DR   HOGENOM; HOG000237620; -.
DR   KO; K01745; -.
DR   OMA; NFAHGHS; -.
DR   BioCyc; PFLU205922:G1G4S-369-MONOMER; -.
DR   UniPathway; UPA00379; UER00549.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   CDD; cd00332; PAL-HAL; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   InterPro; IPR001106; Aromatic_Lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR10362; PTHR10362; 1.
DR   Pfam; PF00221; Lyase_aromatic; 1.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR01225; hutH; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KJE7.
DR   SWISS-2DPAGE; Q3KJE7.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002704};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00831223};
KW   Histidine metabolism {ECO:0000256|SAAS:SAAS00765967};
KW   Lyase {ECO:0000256|RuleBase:RU003954, ECO:0000256|SAAS:SAAS00765964,
KW   ECO:0000313|EMBL:ABA72109.1}.
FT   COILED      292    312       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   507 AA;  54135 MW;  9F675E2D78659CCE CRC64;
     MSQAEKIVIA DAPMRWQDVV AVARHGAQLE LSAQTWARIE NAQGIVQRIV ASGERAYGVN
     TGLGALCNVS LKDEQLSQLS RNTLLSHACG VGPVLADEQT RAIMCAAIRN YSHGKSGIHR
     RVVEALLALL NRGITPQVPS QGSVGYLTHM AHIGIALLGV GNVSYRGQVV CAQQALAEEG
     LQPVQLGAKD GLCLVNGTPC MTGLGCLAIA DATRLLQWAD VIGAMSFEAQ RGQIAAFDAE
     IIALKPHPGM QQVGVNLRAL LDGSEVIASS KGIRTQDALS IRSIPQVHGA ARDQLEHAIK
     QIETELNGCT DNPLLLGTPD DFRVMSQANP HGQSVALAAD LLAIAMAEIG SIAERRLDRL
     INPHVSGLPA FLVANPGVNS GMMIVQYVAA SLCAENRQLA QPAVLDNYVT SGLQEDHLSM
     GTNAALKLHR ALENCTQILA IEYLLAAQAF EFLKEQRFGA GTDTAWRLLR EKVPAYDQDR
     WLAPDIAAAA SVLKDPDLLH NALPNLH
//

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