(data stored in SCRATCH zone)

SWISSPROT: Q3KJJ2_PSEPF

ID   Q3KJJ2_PSEPF            Unreviewed;       355 AA.
AC   Q3KJJ2;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 100.
DE   RecName: Full=Adenine DNA glycosylase {ECO:0000256|RuleBase:RU365096};
DE            EC=3.2.2.31 {ECO:0000256|RuleBase:RU365096};
GN   OrderedLocusNames=Pfl01_0320 {ECO:0000313|EMBL:ABA72064.1};
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA72064.1, ECO:0000313|Proteomes:UP000002704};
RN   [1] {ECO:0000313|EMBL:ABA72064.1, ECO:0000313|Proteomes:UP000002704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA72064.1,
RC   ECO:0000313|Proteomes:UP000002704};
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Adenine glycosylase active on G-A mispairs.
CC       {ECO:0000256|RuleBase:RU365096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC         oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC         apurinic site.; EC=3.2.2.31;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU365096};
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
CC       {ECO:0000256|RuleBase:RU365096}.
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DR   EMBL; CP000094; ABA72064.1; -; Genomic_DNA.
DR   RefSeq; WP_011332014.1; NC_007492.2.
DR   STRING; 205922.Pfl01_0320; -.
DR   EnsemblBacteria; ABA72064; ABA72064; Pfl01_0320.
DR   KEGG; pfo:Pfl01_0320; -.
DR   eggNOG; ENOG4105CEN; Bacteria.
DR   eggNOG; COG1194; LUCA.
DR   HOGENOM; HOG000028744; -.
DR   KO; K03575; -.
DR   OMA; RDPYRVW; -.
DR   BioCyc; PFLU205922:G1G4S-324-MONOMER; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0019104; F:DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd03431; DNA_Glycosylase_C; 1.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; -; 1.
DR   InterPro; IPR005760; A/G_AdeGlyc_MutY.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR000445; HhH_motif.
DR   InterPro; IPR023170; HTH_base_excis_C.
DR   InterPro; IPR029119; MutY_C.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   Pfam; PF00633; HHH; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF14815; NUDIX_4; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR01084; mutY; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KJJ2.
DR   SWISS-2DPAGE; Q3KJJ2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002704};
KW   DNA damage {ECO:0000256|RuleBase:RU365096};
KW   Glycosidase {ECO:0000256|RuleBase:RU365096,
KW   ECO:0000313|EMBL:ABA72064.1};
KW   Hydrolase {ECO:0000313|EMBL:ABA72064.1};
KW   Iron {ECO:0000256|RuleBase:RU365096}.
FT   DOMAIN       39    190       ENDO3c. {ECO:0000259|SMART:SM00478}.
SQ   SEQUENCE   355 AA;  39497 MW;  A39D2E97D0C52BC6 CRC64;
     MRAEQFSTAV LEWFDRHGRH DLPWQQNINP YRVWVSEIML QQTQVSTVLN YFDRFMAALP
     TVEALAAAPE DEVLHLWTGL GYYTRARNLQ KTAKIVVSQY GGEFPRDVEK LTELPGIGLS
     TAGAIGSISM GLRAPILDGN VKRVLARFTA QEGYPGEPKV AKQLWANAER FTPQDRVNAY
     TQAMMDLGAT LCTRSKPSCL LCPLEKGCEA HMLGLETRYP IPKPRKAIPQ KRTLMPLLAN
     EDGAILLYRR PSSGLWGGLW SLPELDDLDD LQHLAAQHSL ELGEQQALPS LVHTFSHFQL
     SIEPWLVQVQ EAGGHVAEAD WLWYNLATPP RLGLAAPVKT LLERAAAVLN AGEST
//

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