(data stored in SCRATCH zone)

SWISSPROT: Q3KKA4_PSEPF

ID   Q3KKA4_PSEPF            Unreviewed;       317 AA.
AC   Q3KKA4;
DT   08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   08-NOV-2005, sequence version 1.
DT   08-MAY-2019, entry version 119.
DE   RecName: Full=Homoserine kinase {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000256|SAAS:SAAS00767460};
DE            Short=HK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            Short=HSK {ECO:0000256|HAMAP-Rule:MF_00301};
DE            EC=2.7.1.39 {ECO:0000256|HAMAP-Rule:MF_00301};
GN   Name=thrB {ECO:0000256|HAMAP-Rule:MF_00301,
GN   ECO:0000313|EMBL:ABA71802.1};
GN   OrderedLocusNames=Pfl01_0058 {ECO:0000313|EMBL:ABA71802.1};
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922 {ECO:0000313|EMBL:ABA71802.1, ECO:0000313|Proteomes:UP000002704};
RN   [1] {ECO:0000313|EMBL:ABA71802.1, ECO:0000313|Proteomes:UP000002704}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1 {ECO:0000313|EMBL:ABA71802.1,
RC   ECO:0000313|Proteomes:UP000002704};
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine;
CC         Xref=Rhea:RHEA:13985, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57590, ChEBI:CHEBI:456216;
CC         EC=2.7.1.39; Evidence={ECO:0000256|HAMAP-Rule:MF_00301,
CC         ECO:0000256|SAAS:SAAS01124410};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 4/5. {ECO:0000256|HAMAP-
CC       Rule:MF_00301, ECO:0000256|SAAS:SAAS00767466}.
CC   -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00301, ECO:0000256|SAAS:SAAS00767468}.
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DR   EMBL; CP000094; ABA71802.1; -; Genomic_DNA.
DR   RefSeq; WP_011331781.1; NC_007492.2.
DR   STRING; 205922.Pfl01_0058; -.
DR   PRIDE; Q3KKA4; -.
DR   EnsemblBacteria; ABA71802; ABA71802; Pfl01_0058.
DR   KEGG; pfo:Pfl01_0058; -.
DR   eggNOG; ENOG4105CUV; Bacteria.
DR   eggNOG; COG2334; LUCA.
DR   HOGENOM; HOG000004810; -.
DR   KO; K02204; -.
DR   OMA; AGALRFW; -.
DR   BioCyc; PFLU205922:G1G4S-59-MONOMER; -.
DR   UniPathway; UPA00050; UER00064.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004413; F:homoserine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05153; HomoserineK_II; 1.
DR   HAMAP; MF_00301; Homoser_kinase_2; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR005280; Homoserine_kinase_II.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   TIGRFAMs; TIGR00938; thrB_alt; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3KKA4.
DR   SWISS-2DPAGE; Q3KKA4.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767464};
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767472};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002704};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767471, ECO:0000313|EMBL:ABA71802.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767462};
KW   Threonine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767467};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00301,
KW   ECO:0000256|SAAS:SAAS00767469, ECO:0000313|EMBL:ABA71802.1}.
FT   DOMAIN       28    256       APH. {ECO:0000259|Pfam:PF01636}.
SQ   SEQUENCE   317 AA;  35379 MW;  BB16F827C80629C8 CRC64;
     MSVFTPLARP ELETFLAPYG LGRLLDFQGI AAGSENTNFF ISMEKGEFVL TLVERGPVQE
     MPFFIDLLDV LHEADLPVPY ALRTTDGVAL RELKGKPALL QPRLAGKHIK QANAQHCAQV
     GDLQAHLHLA TQGDNMIKRK TDRGLDWMLE EGTQFLSHLS DEPRALLQKA LDEITQQREK
     ILALPRANIH ADLFRDNAMF EGTHLTGLID FYNACSGPML YDVAIALNDW CSDDNGLIDG
     PRARAFLGAY AALRPFTAAE AELWPTMLRV ACVRFWLSRL IAAESFAGQD VLIHDPKEFE
     QRLAQRQTVS TPLPFAL
//

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