(data stored in ACNUC18858 zone)

SWISSPROT: GCNT7_MOUSE

ID   GCNT7_MOUSE             Reviewed;         433 AA.
AC   Q3V3K7; B2RSZ6; Q3V174;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   11-DEC-2019, entry version 100.
DE   RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7;
DE            EC=2.4.1.-;
GN   Name=Gcnt7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 55-433 (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Head, and Spinal cord;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Glycosyltransferase. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass type II membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3V3K7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3V3K7-2; Sequence=VSP_027537;
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family.
CC       {ECO:0000305}.
DR   EMBL; AK039414; BAE20545.1; -; mRNA.
DR   EMBL; AK132647; BAE21278.1; -; mRNA.
DR   EMBL; AL833787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC139073; AAI39074.1; -; mRNA.
DR   EMBL; BC139076; AAI39077.1; -; mRNA.
DR   CCDS; CCDS17133.1; -. [Q3V3K7-1]
DR   RefSeq; NP_001034649.1; NM_001039560.3. [Q3V3K7-1]
DR   RefSeq; XP_006500059.1; XM_006499996.3. [Q3V3K7-1]
DR   SMR; Q3V3K7; -.
DR   STRING; 10090.ENSMUSP00000096659; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   PhosphoSitePlus; Q3V3K7; -.
DR   PaxDb; Q3V3K7; -.
DR   PRIDE; Q3V3K7; -.
DR   Ensembl; ENSMUST00000099060; ENSMUSP00000096659; ENSMUSG00000074569. [Q3V3K7-1]
DR   GeneID; 654821; -.
DR   KEGG; mmu:654821; -.
DR   UCSC; uc008ocx.1; mouse. [Q3V3K7-1]
DR   UCSC; uc012cko.1; mouse. [Q3V3K7-2]
DR   CTD; 140687; -.
DR   MGI; MGI:3606143; Gcnt7.
DR   eggNOG; KOG0799; Eukaryota.
DR   eggNOG; ENOG410XQ7M; LUCA.
DR   GeneTree; ENSGT00940000160402; -.
DR   HOGENOM; HOG000293251; -.
DR   InParanoid; Q3V3K7; -.
DR   OMA; GMICAFI; -.
DR   OrthoDB; 791893at2759; -.
DR   PhylomeDB; Q3V3K7; -.
DR   TreeFam; TF315534; -.
DR   Reactome; R-MMU-913709; O-linked glycosylation of mucins.
DR   UniPathway; UPA00378; -.
DR   PRO; PR:Q3V3K7; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q3V3K7; protein.
DR   Bgee; ENSMUSG00000074569; Expressed in 21 organ(s), highest expression level in olfactory epithelium.
DR   ExpressionAtlas; Q3V3K7; baseline and differential.
DR   Genevisible; Q3V3K7; MM.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008375; F:acetylglucosaminyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   Pfam; PF02485; Branch; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q3V3K7.
DR   SWISS-2DPAGE; Q3V3K7.
KW   Alternative splicing; Disulfide bond; Glycoprotein; Glycosyltransferase;
KW   Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..433
FT                   /note="Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-
FT                   1,6-N-acetylglucosaminyltransferase 7"
FT                   /id="PRO_0000299039"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..25
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..433
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        57..209
FT                   /evidence="ECO:0000250"
FT   DISULFID        143..358
FT                   /evidence="ECO:0000250"
FT   DISULFID        164..191
FT                   /evidence="ECO:0000250"
FT   DISULFID        367..398
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         328..359
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_027537"
SQ   SEQUENCE   433 AA;  48580 MW;  FC43FB55026CD23B CRC64;
     MSQLRTTKAG LVACGMICAF IFLYLRNPGP EEAEAEAEAE PTNPAVVECG FYPDELCSAL
     FDGKKAAPQI AQFCKPPQNS EVPARLRTPG NCSRLARGLH FITRPLSAEE GNFSLAYVIH
     APRELVMFVR LLRAIYAPQN VYCIHSDENA PKKFKSAMQT FVDCFGNIFL SSKTQKVAHD
     NLRRLQAEID CMRDLVHSPF QWHYVMNLCG QEFPIKTNKE IIYDIRTRWK GKNITPGVTP
     PANSKPKTGQ GPPKPSPDEN SYTAPNTIFK QSPPHNLTIS SGSAHYALTR KFVEFVLTDP
     RAKDMLQWSK DIQSPEKHYW VTLNRLKDAP GATPDAGWEG HIRATKWRTE AGDGRKGCTD
     HDAQDTCVYG LGDLPGLIRL PAFFATLEPS SDPLVGVCLE RRHRLRALQQ AEVPPEPHWQ
     FPQQSHFNSQ PHH
//

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