(data stored in SCRATCH zone)

SWISSPROT: Q3Z5L0_SHISS

ID   Q3Z5L0_SHISS            Unreviewed;       179 AA.
AC   Q3Z5L0;
DT   27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 76.
DE   RecName: Full=RNA 2',3'-cyclic phosphodiesterase {ECO:0000256|HAMAP-Rule:MF_01940};
DE            Short=RNA 2',3'-CPDase {ECO:0000256|HAMAP-Rule:MF_01940};
DE            EC=3.1.4.58 {ECO:0000256|HAMAP-Rule:MF_01940};
GN   Name=yadP {ECO:0000313|EMBL:AAZ86952.1};
GN   Synonyms=thpR {ECO:0000256|HAMAP-Rule:MF_01940};
GN   OrderedLocusNames=SSON_0159 {ECO:0000313|EMBL:AAZ86952.1};
OS   Shigella sonnei (strain Ss046).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300269 {ECO:0000313|EMBL:AAZ86952.1, ECO:0000313|Proteomes:UP000002529};
RN   [1] {ECO:0000313|EMBL:AAZ86952.1, ECO:0000313|Proteomes:UP000002529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ss046 {ECO:0000313|EMBL:AAZ86952.1,
RC   ECO:0000313|Proteomes:UP000002529};
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X.,
RA   Wang J., Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S.,
RA   Nie H., Peng J., Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y.,
RA   Qiang B., Hou Y., Yu J., Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic
RT   agents of bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-
CC       phosphomonoester. {ECO:0000256|HAMAP-Rule:MF_01940}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + RNA(n)-2',3'-cyclic phosphate = H(+) + RNA(n)-
CC         2'- phosphate; Xref=Rhea:RHEA:11828, Rhea:RHEA-COMP:13350,
CC         Rhea:RHEA-COMP:13351, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:136820, ChEBI:CHEBI:136821; EC=3.1.4.58;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01940};
CC   -!- SIMILARITY: Belongs to the 2H phosphoesterase superfamily. ThpR
CC       family. {ECO:0000256|HAMAP-Rule:MF_01940}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000038; AAZ86952.1; -; Genomic_DNA.
DR   EnsemblBacteria; AAZ86952; AAZ86952; SSON_0159.
DR   KEGG; ssn:SSON_0159; -.
DR   HOGENOM; HOG000226389; -.
DR   KO; K01975; -.
DR   OMA; GVVWLGC; -.
DR   Proteomes; UP000002529; Chromosome.
DR   GO; GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0008664; F:2'-5'-RNA ligase activity; IEA:InterPro.
DR   HAMAP; MF_01940; RNA_CPDase; 1.
DR   InterPro; IPR009097; cNuc_Pdiesterase.
DR   InterPro; IPR014051; Phosphoesterase_HXTX.
DR   InterPro; IPR004175; RNA_CPDase.
DR   PANTHER; PTHR35561; PTHR35561; 1.
DR   Pfam; PF02834; LigT_PEase; 2.
DR   SUPFAM; SSF55144; SSF55144; 1.
DR   TIGRFAMs; TIGR02258; 2_5_ligase; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q3Z5L0.
DR   SWISS-2DPAGE; Q3Z5L0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002529};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01940}.
FT   DOMAIN       14     92       LigT_PEase. {ECO:0000259|Pfam:PF02834}.
FT   DOMAIN       95    167       LigT_PEase. {ECO:0000259|Pfam:PF02834}.
FT   MOTIF        46     49       HXTX 1. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
FT   MOTIF       128    131       HXTX 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
FT   ACT_SITE     46     46       Proton donor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
FT   ACT_SITE    128    128       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01940}.
SQ   SEQUENCE   179 AA;  20299 MW;  6A5A4709D4BF9831 CRC64;
     MPHMSEPQRL FFAIDLPAEI REQIIHWRAT HFPPEAGRPV AADNLHLTLA FLGEVSAEKE
     KALSLLAGRI RQPGFTLTLD DAGQWLRSRV VWLGMRQPPR GLIQLANMLR SQAARSGCFQ
     SNRPFHPHIT LLRDASEAVT IPPPGFNWSY AVTEFTLYAS SFARGRTRYT PLKRWALTQ
//

If you have problems or comments...

PBIL Back to PBIL home page