(data stored in SCRATCH zone)

SWISSPROT: Q47SP5_THEFY

ID   Q47SP5_THEFY            Unreviewed;       368 AA.
AC   Q47SP5;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 103.
DE   SubName: Full=Streptogrisin C. Serine peptidase. MEROPS family S01A {ECO:0000313|EMBL:AAZ54522.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Tfu_0484 {ECO:0000313|EMBL:AAZ54522.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54522.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
RN   [2] {ECO:0000213|PDB:2PFE}
RP   X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 183-368, AND DISULFIDE
RP   BONDS.
RX   PubMed=17543987; DOI=10.1016/j.jmb.2007.04.078;
RA   Kelch B.A., Agard D.A.;
RT   "Mesophile versus thermophile: insights into the structural mechanisms
RT   of kinetic stability.";
RL   J. Mol. Biol. 370:784-795(2007).
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DR   EMBL; CP000088; AAZ54522.1; -; Genomic_DNA.
DR   RefSeq; WP_011290931.1; NC_007333.1.
DR   PDB; 2PFE; X-ray; 1.44 A; A/B=183-368.
DR   PDBsum; 2PFE; -.
DR   SMR; Q47SP5; -.
DR   STRING; 269800.Tfu_0484; -.
DR   EnsemblBacteria; AAZ54522; AAZ54522; Tfu_0484.
DR   KEGG; tfu:Tfu_0484; -.
DR   eggNOG; ENOG4106T9R; Bacteria.
DR   eggNOG; ENOG410XQ6H; LUCA.
DR   HOGENOM; HOG000253137; -.
DR   KO; K18546; -.
DR   OMA; FYSGAQA; -.
DR   OrthoDB; 1110723at2; -.
DR   BioCyc; TFUS269800:G1G4Q-493-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 3.30.300.50; -; 1.
DR   InterPro; IPR004236; Pept_S1_alpha_lytic.
DR   InterPro; IPR001316; Pept_S1A_streptogrisin.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR035070; Streptogrisin_prodomain.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF02983; Pro_Al_protease; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PIRSF; PIRSF001134; Streptogrisin; 1.
DR   PRINTS; PR00861; ALYTICPTASE.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q47SP5.
DR   SWISS-2DPAGE; Q47SP5.
KW   3D-structure {ECO:0000213|PDB:2PFE};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001134-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    368       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004233897.
FT   DOMAIN      112    166       Pro_Al_protease. {ECO:0000259|Pfam:
FT                                PF02983}.
FT   DOMAIN      185    357       Peptidase S1. {ECO:0000259|Pfam:PF00089}.
FT   COILED       43     70       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    217    217       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR001134-1}.
FT   ACT_SITE    241    241       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR001134-1}.
FT   ACT_SITE    322    322       Charge relay system. {ECO:0000256|PIRSR:
FT                                PIRSR001134-1}.
FT   DISULFID    198    218       {ECO:0000213|PDB:2PFE, ECO:0000256|PIRSR:
FT                                PIRSR001134-2}.
FT   DISULFID    280    290       {ECO:0000213|PDB:2PFE, ECO:0000256|PIRSR:
FT                                PIRSR001134-2}.
FT   DISULFID    316    343       {ECO:0000213|PDB:2PFE, ECO:0000256|PIRSR:
FT                                PIRSR001134-2}.
SQ   SEQUENCE   368 AA;  38031 MW;  5FCE3C9B47589E7A CRC64;
     MNHSSRRTTS LLFTAALAAT ALVAATTPAS AQELALKRDL GLSDAEVAEL RAAKAEAVEL
     EEELRDSLGS DFGGVYLDAD TTEITVAVTD PAAVSRVDAD DVTVDVVDFG ETALNDFVAS
     LNAIADTADP KVTGWYTDLE SDAVVITTLR GGTPAAEELA ERAGLDERAV RIVEEDEEPQ
     SLAAIIGGNP YYFGNYRCSI GFSVRQGSQT GFATAGHCGS TGTRVSSPSG TVAGSYFPGR
     DMGWVRITSA DTVTPLVNRY NGGTVTVTGS QEAATGSSVC RSGATTGWRC GTIQSKNQTV
     RYAEGTVTGL TRTTACAEGG DSGGPWLTGS QAQGVTSGGT GDCRSGGITF FQPINPLLSY
     FGLQLVTG
//

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