(data stored in SCRATCH zone)

SWISSPROT: Q47U05_THEFY

ID   Q47U05_THEFY            Unreviewed;       449 AA.
AC   Q47U05;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   08-MAY-2019, entry version 108.
DE   RecName: Full=Replicative DNA helicase {ECO:0000256|RuleBase:RU362085};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU362085};
GN   OrderedLocusNames=Tfu_0019 {ECO:0000313|EMBL:AAZ54059.1};
OS   Thermobifida fusca (strain YX).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Thermobifida.
OX   NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54059.1, ECO:0000313|Proteomes:UP000000434};
RN   [1] {ECO:0000313|Proteomes:UP000000434}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YX {ECO:0000313|Proteomes:UP000000434};
RX   PubMed=17209016; DOI=10.1128/JB.01899-06;
RA   Lykidis A., Mavromatis K., Ivanova N., Anderson I., Land M.,
RA   DiBartolo G., Martinez M., Lapidus A., Lucas S., Copeland A.,
RA   Richardson P., Wilson D.B., Kyrpides N.;
RT   "Genome sequence and analysis of the soil cellulolytic actinomycete
RT   Thermobifida fusca YX.";
RL   J. Bacteriol. 189:2477-2486(2007).
CC   -!- FUNCTION: Participates in initiation and elongation during
CC       chromosome replication; it exhibits DNA-dependent ATPase activity.
CC       {ECO:0000256|RuleBase:RU362085}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU362085};
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC       {ECO:0000256|RuleBase:RU362085}.
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DR   EMBL; CP000088; AAZ54059.1; -; Genomic_DNA.
DR   RefSeq; WP_011290468.1; NC_007333.1.
DR   STRING; 269800.Tfu_0019; -.
DR   EnsemblBacteria; AAZ54059; AAZ54059; Tfu_0019.
DR   KEGG; tfu:Tfu_0019; -.
DR   eggNOG; ENOG4105CDU; Bacteria.
DR   eggNOG; COG0305; LUCA.
DR   HOGENOM; HOG000113195; -.
DR   KO; K02314; -.
DR   OMA; FQIAEAR; -.
DR   OrthoDB; 1709134at2; -.
DR   BioCyc; TFUS269800:G1G4Q-19-MONOMER; -.
DR   Proteomes; UP000000434; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR   CDD; cd00984; DnaB_C; 1.
DR   Gene3D; 1.10.860.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR   InterPro; IPR007692; DNA_helicase_DnaB.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR   InterPro; IPR016136; DNA_helicase_N/primase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00772; DnaB; 1.
DR   Pfam; PF03796; DnaB_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48024; SSF48024; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00665; DnaB; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q47U05.
DR   SWISS-2DPAGE; Q47U05.
KW   ATP-binding {ECO:0000256|RuleBase:RU362085};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000434};
KW   DNA replication {ECO:0000256|RuleBase:RU362085,
KW   ECO:0000256|SAAS:SAAS00740714};
KW   DNA-binding {ECO:0000256|RuleBase:RU362085,
KW   ECO:0000256|SAAS:SAAS00740674};
KW   Helicase {ECO:0000256|RuleBase:RU362085, ECO:0000313|EMBL:AAZ54059.1};
KW   Hydrolase {ECO:0000256|RuleBase:RU362085,
KW   ECO:0000313|EMBL:AAZ54059.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362085};
KW   Primosome {ECO:0000256|RuleBase:RU362085};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000434}.
FT   DOMAIN      185    449       SF4 helicase. {ECO:0000259|PROSITE:
FT                                PS51199}.
SQ   SEQUENCE   449 AA;  49494 MW;  3530610EE0DAB8B9 CRC64;
     MSVDHSVEEV GYDRTPPHDI MAEQCVLGGM LLSKEAIIQV VEILSSSDFY RPAHQTIYDT
     IVDLFARGEP VDAISVHAEL TKRGEIARVG GAPYLHTLTD TVPTAANAGY YARIVADRAV
     LRRLVEAGTR IAQLGYSGDG DVDDLVDQAQ AEIFKVAERR TSEDYLPLSD IMPGALDELE
     AIASHDDTLT GVPTGFTDFD ALSNGLHPGQ MIIIAARPAV GKSTLALDFA RSAAIKHQLT
     TVFFSLEMGR NEIVMRLLSA EARVPLHTMR SGMMTDEDWA RLARRMGEVA GAPLFIDDSP
     NLTMMEIRAK CRRLKQQHDL KLVIVDYLQL LSSHGRVESR QQEVSEMSRS LKLLAKELEV
     PVVALSQLNR GPEQRTDKKP QISDLRESGS IEQDADMVIL LYREDVHEKE SPRAGEADLI
     VAKHRNGPTA TVTVAFQGHY SRFVDMAPG
//

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