(data stored in ACNUC16935 zone)

SWISSPROT: NEDD8_RABIT

ID   NEDD8_RABIT             Reviewed;          81 AA.
AC   Q4PLJ0;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   30-AUG-2017, entry version 78.
DE   RecName: Full=NEDD8;
DE   AltName: Full=Neddylin;
DE   AltName: Full=Ubiquitin-like protein Nedd8;
DE   Flags: Precursor;
GN   Name=NEDD8;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RA   Li Y., Li Y., Wang Z., Mai G.;
RT   "Neural precursor cell expressed, developmentally down-regulated gene
RT   8 (nedd8) in retina with circadian rhythm.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Ubiquitin-like protein which plays an important role in
CC       cell cycle control and embryogenesis. Covalent attachment to its
CC       substrates requires prior activation by the E1 complex UBE1C-
CC       APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to
CC       cullins activates their associated E3 ubiquitin ligase activity,
CC       and thus promotes polyubiquitination and proteasomal degradation
CC       of cyclins and other regulatory proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with NUB1 and AHR. Covalently attached
CC       to cullins and p53 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Mainly nuclear. {ECO:0000250}.
CC   -!- PTM: Cleavage of precursor form by UCHL3 or SENP8 is necessary for
CC       function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin family. {ECO:0000305}.
DR   EMBL; DQ067448; AAY67833.1; -; mRNA.
DR   RefSeq; NP_001075681.1; NM_001082212.1.
DR   UniGene; Ocu.6280; -.
DR   ProteinModelPortal; Q4PLJ0; -.
DR   SMR; Q4PLJ0; -.
DR   STRING; 9986.ENSOCUP00000002526; -.
DR   Ensembl; ENSOCUT00000002907; ENSOCUP00000002526; ENSOCUG00000002910.
DR   GeneID; 100009008; -.
DR   KEGG; ocu:100009008; -.
DR   CTD; 4738; -.
DR   eggNOG; KOG0005; Eukaryota.
DR   eggNOG; COG5272; LUCA.
DR   GeneTree; ENSGT00880000137943; -.
DR   HOGENOM; HOG000233942; -.
DR   HOVERGEN; HBG000057; -.
DR   InParanoid; Q4PLJ0; -.
DR   KO; K12158; -.
DR   OMA; GKQMTDD; -.
DR   OrthoDB; EOG091G178I; -.
DR   TreeFam; TF300072; -.
DR   Proteomes; UP000001811; Chromosome 17.
DR   Bgee; ENSOCUG00000002910; -.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR   GO; GO:0045116; P:protein neddylation; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
DR   InterPro; IPR019956; Ubiquitin.
DR   InterPro; IPR029071; Ubiquitin-rel_dom.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR000626; Ubiquitin_dom.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4PLJ0.
DR   SWISS-2DPAGE; Q4PLJ0.
KW   Acetylation; Complete proteome; Isopeptide bond; Nucleus;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN         1     76       NEDD8.
FT                                /FTId=PRO_0000042771.
FT   PROPEP       77     81       {ECO:0000250}.
FT                                /FTId=PRO_0000042772.
FT   REGION       70     72       Interaction with UBE1C. {ECO:0000250}.
FT   SITE          8      8       Interaction with UBE1C. {ECO:0000250}.
FT   SITE         44     44       Interaction with UBE1C. {ECO:0000250}.
FT   MOD_RES      48     48       N6-acetyllysine.
FT                                {ECO:0000250|UniProtKB:P29595}.
FT   CROSSLNK     76     76       Glycyl lysine isopeptide (Gly-Lys)
FT                                (interchain with K-? in acceptor
FT                                proteins). {ECO:0000255|PROSITE-
FT                                ProRule:PRU00214}.
SQ   SEQUENCE   81 AA;  9072 MW;  DC2FE102BE4725D2 CRC64;
     MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK
     ILGGSVLHLV LALRGGGGLR Q
//

If you have problems or comments...

PBIL Back to PBIL home page