(data stored in SCRATCH zone)

SWISSPROT: Q4W985_ASPFU

ID   Q4W985_ASPFU            Unreviewed;       453 AA.
AC   Q4W985;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 70.
DE   RecName: Full=Mannan endo-1,6-alpha-mannosidase {ECO:0000256|PIRNR:PIRNR016302};
DE            EC=3.2.1.101 {ECO:0000256|PIRNR:PIRNR016302};
GN   ORFNames=AFUA_4G00620 {ECO:0000313|EMBL:EAL84356.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84356.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84356.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in
CC         unbranched (1->6)-mannans.; EC=3.2.1.101;
CC         Evidence={ECO:0000256|PIRNR:PIRNR016302};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 76 family.
CC       {ECO:0000256|PIRNR:PIRNR016302}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84356.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000017; EAL84356.1; -; Genomic_DNA.
DR   RefSeq; XP_746394.1; XM_741301.1.
DR   EnsemblFungi; EAL84356; EAL84356; AFUA_4G00620.
DR   GeneID; 3503776; -.
DR   KEGG; afm:AFUA_4G00620; -.
DR   EuPathDB; FungiDB:Afu4g00620; -.
DR   HOGENOM; HOG000178818; -.
DR   InParanoid; Q4W985; -.
DR   KO; K08257; -.
DR   OMA; YERACEP; -.
DR   OrthoDB; 844700at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008496; F:mannan endo-1,6-alpha-mannosidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR   GO; GO:0009272; P:fungal-type cell wall biogenesis; IBA:GO_Central.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR005198; Glyco_hydro_76.
DR   InterPro; IPR014480; Mannan-1_6-alpha_mannosidase.
DR   PANTHER; PTHR12145; PTHR12145; 1.
DR   Pfam; PF03663; Glyco_hydro_76; 1.
DR   PIRSF; PIRSF016302; Man_a_manosd; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W985.
DR   SWISS-2DPAGE; Q4W985.
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR016302};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR016302, ECO:0000313|EMBL:EAL84356.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..453
FT                   /note="Mannan endo-1,6-alpha-mannosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004246000"
FT   TRANSMEM        430..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          392..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  50064 MW;  19B8526E3E970F24 CRC64;
     MHCMQLLWLL TLSPAYSIPL DPNDPTSIKQ AAHHVAANML SHYTGMKPGD NPGNLPPPYY
     WWEAGAMFNA LIDYWYLTGD STWNAITTQA LTWQAGHTGT FMPTNQTKTE GNDDQAFWAF
     AAMSAAERNF PDPDPDHGPG WLAMAQAVFN TQAARWDEDT CGGGLRWQIF SFNNGWNYKN
     TISNGCFFHL AARLARYTGN RTYAEWAERV WDWTVDVGFI TDDWLFYDGA DVLLNCSDLN
     RIEWTYNSGV YLLGAANMYN CYKTEGDSRW EARTKHILQA TDAFFAEDPA MVMYERACEL
     VDTCQVDQRA FKGFLARWMA AATQVAPFTY DWVMPRLRAS AAAAARTCTG GPDGAACGLK
     WTTGVWDGSE DVGLQMSALE VIQNLLVDRV DPPVTDATGG TSVGDPSGGM EQPDPRPPVL
     TMTITGADRA GAGLLTAMLG VLMIGTTGWL LYE
//

If you have problems or comments...

PBIL Back to PBIL home page