(data stored in SCRATCH zone)

SWISSPROT: Q4W9N1_ASPFU

ID   Q4W9N1_ASPFU            Unreviewed;      1418 AA.
AC   Q4W9N1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 77.
DE   RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN   ORFNames=AFUA_4G04350 {ECO:0000313|EMBL:EAL84582.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84582.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84582.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC       the other cwf proteins as part of the spliceosome.
CC       {ECO:0000256|PIRNR:PIRNR038901}.
CC   -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC       spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC       {ECO:0000256|PIRNR:PIRNR038901}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC   -!- SIMILARITY: Belongs to the CWF11 family.
CC       {ECO:0000256|PIRNR:PIRNR038901}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84582.1}.
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DR   EMBL; AAHF01000016; EAL84582.1; -; Genomic_DNA.
DR   RefSeq; XP_746620.1; XM_741527.1.
DR   STRING; 746128.CADAFUBP00009588; -.
DR   EnsemblFungi; EAL84582; EAL84582; AFUA_4G04350.
DR   GeneID; 3503992; -.
DR   KEGG; afm:AFUA_4G04350; -.
DR   EuPathDB; FungiDB:Afu4g04350; -.
DR   HOGENOM; HOG000170551; -.
DR   InParanoid; Q4W9N1; -.
DR   KO; K12874; -.
DR   OMA; WQHLVES; -.
DR   OrthoDB; 867854at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR   InterPro; IPR032174; Aquarius_N.
DR   InterPro; IPR026300; CWF11_fam.
DR   InterPro; IPR041679; DNA2/NAM7-like_AAA.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10887:SF5; PTHR10887:SF5; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF16399; Aquarius_N; 1.
DR   PIRSF; PIRSF038901; AQR_cwf11; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9N1.
DR   SWISS-2DPAGE; Q4W9N1.
KW   ATP-binding {ECO:0000313|EMBL:EAL84582.1};
KW   Helicase {ECO:0000313|EMBL:EAL84582.1};
KW   Hydrolase {ECO:0000313|EMBL:EAL84582.1};
KW   mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW   mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW   Nucleotide-binding {ECO:0000313|EMBL:EAL84582.1};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR038901};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          24..807
FT                   /note="Aquarius_N"
FT                   /evidence="ECO:0000259|Pfam:PF16399"
FT   DOMAIN          811..1107
FT                   /note="AAA_11"
FT                   /evidence="ECO:0000259|Pfam:PF13086"
FT   DOMAIN          1119..1310
FT                   /note="AAA_12"
FT                   /evidence="ECO:0000259|Pfam:PF13087"
FT   REGION          758..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        760..777
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1418 AA;  161497 MW;  9D77623934CA5824 CRC64;
     MGLQTRQAMA QGLDSRPTVA DFREDSSWVQ LAKTHWLGAS TVRKAKQDVI RQGLWEPLEA
     ENFSLRSLLT LENLNILEKY LWPTYSEDAS NHHVLLIALI VSIKQRDHLP IWETFSDRPG
     DFSNLFHRIL SMSVDNSLST FSRQSILSFI ISAFQSLENV LIRKECAPLV SISIWHNLSS
     EELRDRIFAK VPSLKKAWRA AGKRYEAGDE TAKARMRFER SWLFTMLLDF LRRLNGSEQE
     LSDNLRYCER FLEYLVDLES QLPTRRYVNT LLKDLNLLPV IRLSQMYRSP GNALFRDLVE
     LLNHFSGFAI DDYTGEPLDP QAIYESHSRE LAHLQRTAMK HFKDKLMILA LSNYGSIEQR
     SELEGQLSAL NDSELQSLCM HLGFRTDYPK QSGVIPTRHL YLEILLSFYE RKVPFQETAS
     RLSIVPTEKD LYDPSFLRNE TYDGSRPLAI PKLNLQYLSL GDFLWRSFLL YRSEAFFQVR
     KDMEAIIKRM QPRSSRDGKT LTFDGFSRMA IPISKPAIIE VAPPKVGSSD PAFVRAEIAI
     EVGRLADHIR KEWDSLRPDD VVFLLAVQPG TANNSVFRDS SVETPSLMHL RTATVVQVLD
     EQGRPLREPV VGHTNGYQSR PRLRRLLLNL DPSAFKADKD RTSQGKQDIY PLINVIARRK
     GRENNFRSIL ENMQRLIVSD VTLPSWIQDI FLGYGDPAGA RYTELPNRLK SVDFRDTFLD
     WQHLVESFPG CTIEPSGNEA SSFGPPYVIE YVENTSKAPS ETSLKKRRRD PVEKEGTSAR
     VIRVSTYKQP NPGPYPVDAP KLNTIRFTPA QVEAIASGTQ PGLTVIVGPP GTGKTDVATQ
     IINNIYHDFP KERTLLIAHS NQALNQLFQK IVALDIDERH LLRLGHGEEE LETETSYSKY
     GRVESFLENR NYFLAEVTRL AASIGAEGAH GNSCETAGYF NTVYIQPAWA KFFDHARAES
     TTTEDIIASF PFHAYFSTAP QPVFDPAASK ETLLDVAEGC QRHIDKIFSE LEDIRPFEIL
     RQSRDKANYL LVKEARIIAM TSTHAAMRRQ EIADLGFHYD NVVMEEAAQI TEIESFIPSA
     LQHMKNGELP LKRVVLCGDH LQNSPIIQNL AFRQYAHFEQ SLFLRLVRLG VPVINLDQQG
     RARPSLAELF RWRYHQLGDL PIVHTAQEYK HANAGFQYDY QFINVPDYQG SGEREPTPHF
     IQNLGEAEYA VAIYQYMRLL GYPASKISIL ATYAGQTALI KDVLAHRCAK NALFGMPKIV
     TTVDKYQGEQ NDYVILSLTR TRTVGYLRDV RRLTVALSRS RLGLYILGRR EVFESCYELK
     PAFDLLLQRP DKLMLTTGEM FPTTRSLDDE VQGTPMEGVE HLGQYVFEMT QAKVRAMGDQ
     DLIVDDALPD GENELLDEDE VMLGAGDEPE DDPLHEQT
//

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