(data stored in SCRATCH zone)

SWISSPROT: Q4W9N9_ASPFU

ID   Q4W9N9_ASPFU            Unreviewed;       344 AA.
AC   Q4W9N9;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 97.
DE   SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:EAL84574.1};
DE            EC=2.1.1.45 {ECO:0000313|EMBL:EAL84574.1};
GN   ORFNames=AFUA_4G04270 {ECO:0000313|EMBL:EAL84574.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84574.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84574.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84574.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000016; EAL84574.1; -; Genomic_DNA.
DR   RefSeq; XP_746612.1; XM_741519.1.
DR   STRING; 746128.CADAFUBP00009596; -.
DR   EnsemblFungi; EAL84574; EAL84574; AFUA_4G04270.
DR   GeneID; 3503996; -.
DR   KEGG; afm:AFUA_4G04270; -.
DR   EuPathDB; FungiDB:Afu4g04270; -.
DR   HOGENOM; HOG000257899; -.
DR   InParanoid; Q4W9N9; -.
DR   KO; K00560; -.
DR   OMA; KQYLDLC; -.
DR   OrthoDB; 684306at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004799; F:thymidylate synthase activity; IBA:GO_Central.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; -; 1.
DR   HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   InterPro; IPR020940; Thymidylate_synthase_AS.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; SSF55831; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9N9.
DR   SWISS-2DPAGE; Q4W9N9.
KW   Methyltransferase {ECO:0000313|EMBL:EAL84574.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transferase {ECO:0000313|EMBL:EAL84574.1}.
FT   DOMAIN          40..344
FT                   /note="Thymidylat_synt"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        216
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ   SEQUENCE   344 AA;  38241 MW;  66F2131F3CC3DA59 CRC64;
     MTIQSKDQTS IMSPAAVLPQ DTPSQTGTPT PPHNPAHEEH QYLNLIRTIL AEGEHRPDRT
     GTGTRSIFAP PQLRFSLSKP GATPSSDPIP ILPLLTTKRV FLRAVIAELL WFISGCTSSI
     PLSEAGIKIW DGNGSREFLD KVGLGHREVG DLGPVYGFQW RHFGAEYIDA KTDYTGQGVD
     QLAEVVRKLK ETPFDRRIIM SAWNPADLKK MALPPCHMFA QFYVSYPNGL DNKGSLSCLL
     YQRSCDMGLG VPFNIASYAL LTHILAHATD LNPGTLIHTM GDAHVYLDHV DALNEQLKRE
     PTEFPELRIK RNDRGSGVVD GWKEEEFEVV GYQPHKAIKM NMSV
//

If you have problems or comments...

PBIL Back to PBIL home page