(data stored in SCRATCH zone)

SWISSPROT: Q4W9R1_ASPFU

ID   Q4W9R1_ASPFU            Unreviewed;       308 AA.
AC   Q4W9R1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 71.
DE   RecName: Full=Histidinol-phosphatase {ECO:0000256|RuleBase:RU366003};
DE            Short=HolPase {ECO:0000256|RuleBase:RU366003};
DE            EC=3.1.3.15 {ECO:0000256|RuleBase:RU366003};
GN   ORFNames=AFUA_4G04030 {ECO:0000313|EMBL:EAL84552.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84552.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84552.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-histidinol phosphate = L-histidinol + phosphate;
CC         Xref=Rhea:RHEA:14465, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57699, ChEBI:CHEBI:57980; EC=3.1.3.15;
CC         Evidence={ECO:0000256|RuleBase:RU366003};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
CC       {ECO:0000256|RuleBase:RU366003}.
CC   -!- SIMILARITY: Belongs to the PHP hydrolase family. HisK subfamily.
CC       {ECO:0000256|RuleBase:RU366003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84552.1}.
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DR   EMBL; AAHF01000016; EAL84552.1; -; Genomic_DNA.
DR   RefSeq; XP_746590.1; XM_741497.1.
DR   STRING; 746128.CADAFUBP00009618; -.
DR   EnsemblFungi; EAL84552; EAL84552; AFUA_4G04030.
DR   GeneID; 3503912; -.
DR   KEGG; afm:AFUA_4G04030; -.
DR   EuPathDB; FungiDB:Afu4g04030; -.
DR   HOGENOM; HOG000170774; -.
DR   InParanoid; Q4W9R1; -.
DR   KO; K04486; -.
DR   OMA; DFHPGTE; -.
DR   OrthoDB; 1037271at2759; -.
DR   UniPathway; UPA00031; UER00013.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0004401; F:histidinol-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0000105; P:histidine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR010140; Histidinol_P_phosphatase_HisJ.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   PANTHER; PTHR21039; PTHR21039; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR01856; hisJ_fam; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9R1.
DR   SWISS-2DPAGE; Q4W9R1.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU366003};
KW   Histidine biosynthesis {ECO:0000256|RuleBase:RU366003};
KW   Hydrolase {ECO:0000256|RuleBase:RU366003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          4..214
FT                   /note="PHP"
FT                   /evidence="ECO:0000259|Pfam:PF02811"
SQ   SEQUENCE   308 AA;  35622 MW;  C3D4F2D678DCEFBF CRC64;
     MPFSHHSHSG QFCPGHAKDS LEEIIKLAIS KKFKVFCLTE HMPRAKEDFY PEEIETGNTE
     ASLIANEAAY FAEAVRLREK YADQIQILIG FEIDWIRPES RTLIEQSLSR LPFEFFVGSV
     HHTLTVPIDY DRPMYEKARE LAGGTDKRLF ERYFDEQLDM VTQLRPLVVG HFDLIKLKSD
     DPERSFKQWP SVWERILRNL DFIAGYGGML ELNSAALRKG MSEPYPKEEI CREFLARGGR
     FVLSDDSHGL DQVGFNFHGV LAFMEKAGIS TLHYLELGDE PAVDERFPRT QIRSIHVSEL
     KKMSFWQV
//

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