(data stored in SCRATCH zone)

SWISSPROT: Q4WA08_ASPFU

ID   Q4WA08_ASPFU            Unreviewed;      2043 AA.
AC   Q4WA08;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 96.
DE   SubName: Full=DEAD/DEAH box helicase, putative {ECO:0000313|EMBL:EAL84455.1};
DE            EC=3.6.1.- {ECO:0000313|EMBL:EAL84455.1};
GN   ORFNames=AFUA_4G03070 {ECO:0000313|EMBL:EAL84455.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84455.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84455.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84455.1}.
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DR   EMBL; AAHF01000016; EAL84455.1; -; Genomic_DNA.
DR   RefSeq; XP_746493.1; XM_741400.1.
DR   STRING; 746128.CADAFUBP00009725; -.
DR   EnsemblFungi; EAL84455; EAL84455; AFUA_4G03070.
DR   GeneID; 3504078; -.
DR   KEGG; afm:AFUA_4G03070; -.
DR   EuPathDB; FungiDB:Afu4g03070; -.
DR   HOGENOM; HOG000157749; -.
DR   InParanoid; Q4WA08; -.
DR   KO; K18664; -.
DR   OMA; YKTLNRM; -.
DR   OrthoDB; 154891at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IBA:GO_Central.
DR   Gene3D; 2.60.40.150; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004179; Sec63-dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00270; DEAD; 2.
DR   Pfam; PF00271; Helicase_C; 2.
DR   Pfam; PF02889; Sec63; 2.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM00487; DEXDc; 2.
DR   SMART; SM00490; HELICc; 2.
DR   SMART; SM00973; Sec63; 2.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF52540; SSF52540; 4.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR   PROSITE; PS51194; HELICASE_CTER; 2.
PE   4: Predicted;
DR   PRODOM; Q4WA08.
DR   SWISS-2DPAGE; Q4WA08.
KW   ATP-binding {ECO:0000313|EMBL:EAL84455.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000313|EMBL:EAL84455.1};
KW   Hydrolase {ECO:0000313|EMBL:EAL84455.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:EAL84455.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          331..524
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          560..758
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          1192..1367
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          1397..1608
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1950..1975
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          883..903
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2043 AA;  229193 MW;  594475362841860C CRC64;
     MTLVLNLSTG GFCFDLQSIP SSVLIILYFY RRFRPHIPVK MDGTGPTEQW LSQLTAMREA
     IAALKLPKDP ATEQLSYGSD LDLDLDDEYS SPGTVDDIWD IISSDDETND DLDDINGVPL
     PPAPSTSLYD QAWLEQRCQA ITLQKPGMSA QELAQQITAS LATDSGDDEL QMSLAEIVGF
     DDLDFVIELI GHRAEILAST TSKTEAQTDG LMTGKLQTRA EREQALRQQD FEHKHAPLLP
     AQARSEPRYP HVFKTHDSRN TLALGGKRYG LPVGSRQIDE QRYTEFEIPA SRVGTLASSQ
     KLVEIKSLDG LCRGTFKGYK TLNRMQSLLY DVAYKTSENM LICAPTGAGK TDAAMLTILN
     TIGKNTVPNP IEQPDAIEFA VQVDDFKIVY VAPMKALAAE VTEKLGKRLA WLGIRVRELT
     GDMQLTKREI VETQIIVTTP EKWDVVTRKS TGDTELVQKV RLLIIDEVHM LHDERGAVIE
     SLVARTQRQV ESTQSLIRIV GLSATLPNYV DVAEFLKVNK MAGLFFFDAS FRPVPLEQHF
     IGVKGKPGSK QSRENLDIVA FEKVREMLER GHQVMVFVHS RKDTVLTARM LRQMAVENGC
     EDLFSCHEHE NYSNALRDMK HARARELRDL FASGFGTHHA GMTRSDRNLM ERMFSEGLIK
     VLCCTATLAW GVNLPAAAVV IKGTQLYNPQ EGKFVDLGIL DVLQIFGRAG RPQFQDTGIG
     FICTTHDKLH HYLSAVTAQQ PIESRFSSRL VDNLNAEISL GTVTSVSEGV QWLGYSYLFV
     RMLREPRNYG IDFAEIRDDP MLVQRRRQLI IQAARVLQKS QMIIFNEKTE ELRAKDVGRI
     ASQYYVLQTS IEIFNEMMRP RAGEADVLRM ISMSGEFDNI QARENESKEL DRLRDEAIQT
     EVEGGNDSPH AKTNILLQSY ISRAKLEDFA LVSDMGYVAQ NAARICRALF MIALNRRWGY
     QCQVLLSLCK SIEKQIWPFD HPFHQFDLPQ PILKNLDEKL PTSSLESMRE MDVAEIGQLV
     HNQRMGKTLS KLLDNFPTLS VEAEIAPLNR DVLRIRLSLY PEFSWNDRHH GASEAYWIWV
     ENSETSEIYH HEYFILSRKK LHDEHELNFT IPLSDPLPSQ IYVRAISDRW LGAETVTPVS
     FQHLIRPDTE SVYTDLLNLQ PLPISALNNP ILEELYGQRF QFFNPMQTQI FHLLYHTSAN
     VLLGSPTGSG KTVACELAMW WAFREKPGSK VVYIAPMKAL VRERVMDWGK RLAAPMGLKL
     VELTGDNTPD TRTIRDADII ITTPEKWDGI SRSWQTRDYV RKVSLVIIDE IHLLGGDRGP
     ILEIIVSRMN YIASQSKGSV RLMGMSTACA NATDLANWLG VKEGLFNFRH SVRPVPLEIY
     IDGFPEQRGF CPLMQSMNRP TFLAIKNHSP EKPVIVFVAS RRQTRLTAKD LINYCGMEDN
     PRRFVRMSEE DLQLNLARVK DEALREALSF GIGLHHAGLV ESDRQLAEEL FANNKIQILV
     ATSTLAWGVN LPAHLVVVKG TQYFDAKIEG YKDMDLTDVL QMLGRAGRPQ FDSSGIARIF
     TQESKKAFYK HFLHTGFPVE STLHKVLDNH LGAEISAGTI ATKQDALDYL TWTFFFRRLH
     KNPSYYGLEI SAEEHNTMAA QAIAQDFMID LVDKSLGELA ESSCVVFDSA TGEVDSTPFG
     KIMSYYYLSH KTVRYLMSHA KPNPTFHDVF SWLCSATEFD ELPVRHNEDL INAELARNLP
     LSVESMGDLP LWDPHVKAFL LLQAYMSRID LPISDYVGDQ TSVLDQGIRI IQASIDIMAE
     LGYVRACETL VSLLQSIKSA RWPEDNALSI LPGIEPTSKL QGLPGSLVAL SSLPTASVSG
     LARKLQLPAE FTKAASYLPQ VSVSVANVSS TGITVSLSRR NPPTNAEHRV YAPRFPKPQT
     EGYFLIVCSA SADGKDGELL ALKRVSWSAN NKNQSSNSGS GSGSSQNPSG RSNYRNGALT
     VRSLVKFPQD FLAQYTTATG KGVNVKVISD TYPGMQWVVS NVEVELKPET QSVPESSNYP
     EKA
//

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