(data stored in SCRATCH zone)

SWISSPROT: Q4WA18_ASPFU

ID   Q4WA18_ASPFU            Unreviewed;       735 AA.
AC   Q4WA18;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 69.
DE   SubName: Full=Plasma membrane channel protein (Aqy1), putative {ECO:0000313|EMBL:EAL84445.1};
GN   ORFNames=AFUA_4G02970 {ECO:0000313|EMBL:EAL84445.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84445.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84445.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2] {ECO:0000213|PDB:6DZ7, ECO:0000213|PDB:6E0H, ECO:0000213|PDB:6E1O}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.59 ANGSTROMS).
RX   PubMed=30648972; DOI=10.7554/eLife.43229;
RA   Falzone M.E., Rheinberger J., Lee B.C., Peyear T., Sasset L.,
RA   Raczkowski A.M., Eng E.T., Di Lorenzo A., Andersen O.S., Nimigean C.M.,
RA   Accardi A.;
RT   "Structural basis of Ca2+-dependent activation and lipid transport by a
RT   TMEM16 scramblase.";
RL   Elife 8:0-0(2019).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84445.1}.
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DR   EMBL; AAHF01000016; EAL84445.1; -; Genomic_DNA.
DR   RefSeq; XP_746483.1; XM_741390.1.
DR   PDB; 6DZ7; EM; 3.89 A; A/B=1-735.
DR   PDB; 6E0H; EM; 4.05 A; A/B=1-735.
DR   PDB; 6E1O; EM; 3.59 A; A/B=1-735.
DR   PDBsum; 6DZ7; -.
DR   PDBsum; 6E0H; -.
DR   PDBsum; 6E1O; -.
DR   SMR; Q4WA18; -.
DR   STRING; 746128.CADAFUBP00009735; -.
DR   EnsemblFungi; EAL84445; EAL84445; AFUA_4G02970.
DR   GeneID; 3504033; -.
DR   KEGG; afm:AFUA_4G02970; -.
DR   EuPathDB; FungiDB:Afu4g02970; -.
DR   HOGENOM; HOG000171344; -.
DR   InParanoid; Q4WA18; -.
DR   KO; K19327; -.
DR   OMA; REMCIQF; -.
DR   OrthoDB; 1263362at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IDA:AspGD.
DR   GO; GO:0017128; F:phospholipid scramblase activity; IDA:AspGD.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IDA:AspGD.
DR   GO; GO:0034220; P:ion transmembrane transport; IDA:AspGD.
DR   GO; GO:0045332; P:phospholipid translocation; IDA:AspGD.
DR   InterPro; IPR007632; Anoctamin.
DR   PANTHER; PTHR12308; PTHR12308; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q4WA18.
DR   SWISS-2DPAGE; Q4WA18.
KW   3D-structure {ECO:0000213|PDB:6DZ7, ECO:0000213|PDB:6E0H,
KW   ECO:0000213|PDB:6E1O}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          679..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..699
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  84513 MW;  83B28668CBAA0C3E CRC64;
     MAFNPAPKAV QENHHVDYVI RFNYGDIDTP EAIKKFEVLL LELSEVGLQT EVRQGDENSL
     FVFVRAASKK KLKRAVYQSR VRDWLYGVRN TEPEPASSAK PQSEAERLLV IYHLITVPKA
     EGGAGITPRH GEWKNVDAIF PLHDEETNRQ CMREWSKKTF LSTEDLDRIR NTFGEHVGFY
     FAFLQSYFRF LMFPAAFGFS CWLLLGSFSI IYTVVNCLWC IVFIEYWKRQ EEDLSCRWQT
     KGVSAVHEKR AEFKPEKEIR DESTGEVRGV FPATKRMYRQ LLQVPFALLA AVALGAIIAT
     CFAIEIFISE VYNGPLKGYL VFIPTILVSA LIPTMSAVLL TVATKLNDYE NYETQDAYKV
     ALTQKIFVVN FITSYLPIIL TAFVYVPFAS RIVPYLDVFH LTVRPFVSKE HAIKARTEFS
     INPDRLRKQV IYFTVTAQIV GFALETIVPF VKQRVFREYK EYTKKQHAKA EPGNGAGEKK
     TVSLGDDEDE ARFLTRVRNE AELEDYDVTD DLREMCIQFG YLALFSPVWP LVPVSFLINN
     WVELRSDFFK ICVECKRPWP QRADTIGPWL DSLGFLSWVG SITSSALVYM FSNGHEGPNG
     EPTTIRCWAL LLTIFFSEHL YLIVRYAVRS ALAKLEPPNT RRERIERFMM RKRYLDTVLS
     AESDDDADEV KGVVSSIPPS EITRESLEQD ARDWSKQGTD PTERFWMRQR GWKESAEVGL
     SLITKAKGDE TKKQQ
//

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