(data stored in SCRATCH zone)

SWISSPROT: Q4WCQ6_ASPFU

ID   Q4WCQ6_ASPFU            Unreviewed;      1508 AA.
AC   Q4WCQ6;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 123.
DE   RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE            EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN   ORFNames=AFUA_6G02070 {ECO:0000313|EMBL:EAL85832.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85832.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85832.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate +
CC         phospholipid(Side 2).; EC=7.6.2.1;
CC         Evidence={ECO:0000256|RuleBase:RU362033,
CC         ECO:0000256|SAAS:SAAS01189249};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362033}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362033}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IV subfamily. {ECO:0000256|RuleBase:RU362033,
CC       ECO:0000256|SAAS:SAAS00533978}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85832.1}.
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DR   EMBL; AAHF01000012; EAL85832.1; -; Genomic_DNA.
DR   RefSeq; XP_747870.1; XM_742777.1.
DR   STRING; 746128.CADAFUBP00009356; -.
DR   EnsemblFungi; EAL85832; EAL85832; AFUA_6G02070.
DR   GeneID; 3505310; -.
DR   KEGG; afm:AFUA_6G02070; -.
DR   EuPathDB; FungiDB:Afu6g02070; -.
DR   HOGENOM; HOG000202528; -.
DR   InParanoid; Q4WCQ6; -.
DR   KO; K01530; -.
DR   OMA; FWTGVYT; -.
DR   OrthoDB; 587717at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR   Gene3D; 3.40.1110.10; -; 2.
DR   Gene3D; 3.40.50.1000; -; 2.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006539; P-type_ATPase_IV.
DR   InterPro; IPR032631; P-type_ATPase_N.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR032630; P_typ_ATPase_c.
DR   InterPro; IPR026871; PLip_transp_ATPase.
DR   PANTHER; PTHR24092; PTHR24092; 1.
DR   PANTHER; PTHR24092:SF34; PTHR24092:SF34; 1.
DR   Pfam; PF16212; PhoLip_ATPase_C; 1.
DR   Pfam; PF16209; PhoLip_ATPase_N; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   SUPFAM; SSF81653; SSF81653; 1.
DR   SUPFAM; SSF81660; SSF81660; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   TIGRFAMs; TIGR01652; ATPase-Plipid; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WCQ6.
DR   SWISS-2DPAGE; Q4WCQ6.
KW   ATP-binding {ECO:0000256|RuleBase:RU362033, ECO:0000256|SAAS:SAAS00311808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:EAL85832.1};
KW   Magnesium {ECO:0000256|RuleBase:RU362033, ECO:0000256|SAAS:SAAS00311822};
KW   Membrane {ECO:0000256|RuleBase:RU362033, ECO:0000256|SAAS:SAAS00076974};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362033,
KW   ECO:0000256|SAAS:SAAS00311833};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Translocase {ECO:0000256|RuleBase:RU362033, ECO:0000256|SAAS:SAAS01101229};
KW   Transmembrane {ECO:0000256|RuleBase:RU362033,
KW   ECO:0000256|SAAS:SAAS00311809};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362033,
KW   ECO:0000256|SAAS:SAAS00311798}.
FT   TRANSMEM        139..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        513..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        555..579
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1129..1148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1160..1181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1211..1232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1252..1270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1277..1297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   TRANSMEM        1317..1337
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362033"
FT   DOMAIN          104..155
FT                   /note="PhoLip_ATPase_N"
FT                   /evidence="ECO:0000259|Pfam:PF16209"
FT   DOMAIN          1097..1346
FT                   /note="PhoLip_ATPase_C"
FT                   /evidence="ECO:0000259|Pfam:PF16212"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1376..1508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          885..905
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        16..32
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..68
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..88
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1379..1455
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1467..1492
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1493..1508
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1508 AA;  169464 MW;  4FD06255860D2444 CRC64;
     MASDFLSPDS IDPGNGVREV SSNVSKPTKR QRWATQRVAG AGGVRKRVSI MDRLHKRSEA
     KSEKRGSMLP PTDDSNTESD QDAQGGSNRR VYFNIPIPES ERDEDGQIKT SYPRNKIRTA
     KYTPLTFIPK NIWFQFHNIA NIYFLFIIIL GFFSIFGVDN PALNTVPLIV IVVATAIKDA
     IEDWRRTVLD NELNNSPVYR LVEWNNVNST EDKVSLWRRF KKACTRATIS TYRWIRRLMK
     KNKDVPQMFQ DERRASILTT VTPRASVYSQ RGDHGMEEDA IQMTPVPSPS AEARADWPLP
     AGDSDQFLHP DKRNRDSLQA VTLPVTPPRK GGSVVDPSKQ TIGKARFKRD YWKNIQVGDF
     VRLYNGDPIP ADIVVLSTSD PDGACYVETK NLDGETNLKV RQALNCGRQV RHARDCEKAE
     FLIDSEAPHP NLYAYNGALR WEQRDPDYPD APRREMVEPI TISNMLLRGC SLRNTEWALG
     VVIFTGDETK VMLNSGVTPS KRAKLAKALN WNVIYNFILL FAMCFVSAVV NGVAWGSDDR
     SLNYFDFGSY GSTPVVTAII TFWVALILFQ NLVPISLYIS LEIVRTCQAI FIHSDVFMYY
     EKLGISCVPK SWNISDDVGQ IEYIFSDKTG TLTQNVMDFK KCTINGVSYG EAFTEAQVGM
     IRREGGDADT VAAEAREKIA ADTTKMLQML RRIHDNPYLR DENLTFIAPD YVADLEGQSG
     EAQKQATEHF MLALALCHTV ITEQTPGDPP QIEFKAQSPD EAALVSTARD CGFTLLGRSG
     DDLILNVMGE ERTYTVLNTL EFNSTRKRMS AIIRMPDGTI RLFCKGADSI IYSRLARGKQ
     QELRKKTAEH LEEFAREGLR TLCVAERVLS EEEYRTWSKE HDIAAAALTD REQKLEQVSS
     EIEQELMLIG GTAIEDKLQD GVPDTISLLA DAGIKLWVLT GDKVETAINI GFSCNLLTND
     MELLVFNIPE DQPQRASQEL DEQLQKFGLT GSDEELIAAR EDHRPPPATH AVVIDGDTLK
     LMLSDELKQR FLLLCKQCKS VLCCRVSPAQ KAAVVRLVKN GLNIMALSIG DGANDVAMIQ
     EADVGVGIVG EEGRQAAMSS DYAIGQFRFL QRLILVHGRW SYRRMGETIA NFFYKNMVWT
     IALFWYSLYN DFDGSYLFDY TYIVLVNVAF TSLPVILMGI FDQDVDDKVS LAVPQLYMRG
     IERKEWSQTK FWLYMLDGFY QSIICFYMPY LLFSPATFVH SNGLNINDRT RMGVLVASCA
     VIASNTYILM NTYRWDWLTV LINVISSLLI FFWTGIYSST TASAQFYKAA AEVYGALSFW
     VVLLMTVIIC LLPRFTVKAV QKVFFPRDVD IIREQVTQGK FKYLDQYEAF VPPKAAATSG
     GLSNGSAASS DLGKPIQSSM KQDPFSDDQQ IYPPSVAPTI HTHNPRSQNG SNGTNYSFDT
     TQHPRPQSVQ SAQRTRHSFD RARPSYDVNS DFNSGAMLSR VDSATGIPVP QSPHSPLKSP
     HDPPSYQV
//

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