(data stored in SCRATCH zone)

SWISSPROT: Q4WCT9_ASPFU

ID   Q4WCT9_ASPFU            Unreviewed;       599 AA.
AC   Q4WCT9;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 73.
DE   SubName: Full=MFS drug efflux pump, putative {ECO:0000313|EMBL:EAL85799.1};
GN   ORFNames=AFUA_6G02400 {ECO:0000313|EMBL:EAL85799.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85799.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85799.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85799.1}.
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DR   EMBL; AAHF01000012; EAL85799.1; -; Genomic_DNA.
DR   RefSeq; XP_747837.1; XM_742744.1.
DR   STRING; 746128.CADAFUBP00009323; -.
DR   EnsemblFungi; EAL85799; EAL85799; AFUA_6G02400.
DR   GeneID; 3505258; -.
DR   KEGG; afm:AFUA_6G02400; -.
DR   EuPathDB; FungiDB:Afu6g02400; -.
DR   HOGENOM; HOG000202260; -.
DR   InParanoid; Q4WCT9; -.
DR   OMA; NFFSILM; -.
DR   OrthoDB; 488594at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR010573; Str1/Tri12.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF06609; TRI12; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
DR   PRODOM; Q4WCT9.
DR   SWISS-2DPAGE; Q4WCT9.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        68..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        158..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        264..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        464..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        564..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          68..588
FT                   /note="MFS"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  64131 MW;  FD9BF5E2DC18AD07 CRC64;
     MEVADHSGQS QVDEKAAGQT SMANNQEHKY SHEEIVGLES GGSDTAEGQD IPLIELTAGS
     IQLTFRRFMG FTAMAFLWTG SQIPVYLFGG IPPYIYADIG GADRWIWFVL ANLLALAGVC
     PFVGSLSDLI GRRYVAIIGA SLICLGMIVT STAHTMNIFI AGMAIAGAGA GVNELTALAA
     TSEMAPTSQR GKYVAILIFT IVPFCPSVLW AQLIAAHSGW RYVGAFCGAW GGFGLLATVF
     FYFPPPRVNS QGLSRKEVIR RIDFVGGLLS ITGLILFLAG MQWGGYQYPW TTAHVLAPLI
     LGFVILVAFA AWEIYGAKYP IFPTRLKQEP RTLGLTLVIT FISGANFFSV IMFWPTQSFN
     VYGHDPVQVG LRSLPVGFGI MAGACIVLWL LSVLRGHNKE LLIISSVLMT AGCGAMAVAR
     QDNLYQLWGI LVLAGLGIGG IVVPASIITT IICPDANRLV HQDLIATISA LTLSIRVVGG
     SIGYTIYYNI FISKFVPNAK HFIGGVMGTK LNITNPAYIG EAIELTGASL LEELKTIPGI
     AGSEAAYNAV VAAGQLAYAE SYKWVYYVSI AFGGISILAA CFLGSISQYM DDHVAVVMH
//

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