(data stored in SCRATCH zone)

SWISSPROT: Q4WDL3_ASPFU

ID   Q4WDL3_ASPFU            Unreviewed;       352 AA.
AC   Q4WDL3; Q2VWQ6;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   SubName: Full=Sterol delta 5,6-desaturase ERG3 {ECO:0000313|EMBL:EAL85525.1};
DE            EC=1.3.3.- {ECO:0000313|EMBL:EAL85525.1};
GN   ORFNames=AFUA_6G05140 {ECO:0000313|EMBL:EAL85525.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85525.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85525.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the sterol desaturase family.
CC       {ECO:0000256|SAAS:SAAS00565350}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85525.1}.
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DR   EMBL; AAHF01000012; EAL85525.1; -; Genomic_DNA.
DR   RefSeq; XP_747563.1; XM_742470.1.
DR   STRING; 746128.CADAFUBP00009051; -.
DR   EnsemblFungi; EAL85525; EAL85525; AFUA_6G05140.
DR   GeneID; 3505076; -.
DR   KEGG; afm:AFUA_6G05140; -.
DR   EuPathDB; FungiDB:Afu6g05140; -.
DR   HOGENOM; HOG000200579; -.
DR   InParanoid; Q4WDL3; -.
DR   KO; K00227; -.
DR   OMA; SYIFIWD; -.
DR   OrthoDB; 1249774at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000248; F:C-5 sterol desaturase activity; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016126; P:sterol biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR006694; Fatty_acid_hydroxylase.
DR   Pfam; PF04116; FA_hydroxylase; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WDL3.
DR   SWISS-2DPAGE; Q4WDL3.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000313|EMBL:EAL85525.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        82..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          174..299
FT                   /note="Fatty acid hydroxylase"
FT                   /evidence="ECO:0000259|Pfam:PF04116"
SQ   SEQUENCE   352 AA;  41243 MW;  966C0D555EAC5126 CRC64;
     MDIVLEIWDT FIGDRVYSAL LPLSLSSTVS LPGLTNAANS SLSLFGASKP FVYEPATQLF
     RLEPSKYAYL SAWPRNNIYR QFLSFFLIVW IFGIIVYFIS ATLSYIFIWD KTTVKHPKFL
     KNQIPMEIAQ TMRSMPVMSL LTAPFLVAEV RGYAKLYDSV DEEPFPYYSI LQFPLFIAFT
     DFCIYWIHRG LHHPLIYKSL HKPHHKWIMP SPFASHAFHP LDGWSQSVPY HVFPFIFPLQ
     KLAYVFLFGF INLWTVMIHD GEYVANSPII NGAACHTMHH LYFNYNYGQF TTLWDRLGGS
     YRKPNEELFR RETKMDEAEW KRQTKEMETI LKTVEGEDDR KYLSQEEAKK DL
//

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