(data stored in SCRATCH zone)

SWISSPROT: Q4WDN1_ASPFU

ID   Q4WDN1_ASPFU            Unreviewed;       320 AA.
AC   Q4WDN1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   RecName: Full=Purine nucleoside phosphorylase {ECO:0000256|PIRNR:PIRNR000477};
DE            EC=2.4.2.1 {ECO:0000256|PIRNR:PIRNR000477};
DE   AltName: Full=Inosine-guanosine phosphorylase {ECO:0000256|PIRNR:PIRNR000477};
GN   ORFNames=AFUA_6G05320 {ECO:0000313|EMBL:EAL85507.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85507.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85507.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: The purine nucleoside phosphorylases catalyze the
CC       phosphorolytic breakdown of the N-glycosidic bond in the beta-
CC       (deoxy)ribonucleoside molecules, with the formation of the
CC       corresponding free purine bases and pentose-1-phosphate.
CC       {ECO:0000256|PIRNR:PIRNR000477}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a purine D-ribonucleoside + phosphate = a purine nucleobase +
CC         alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:19805, ChEBI:CHEBI:26386,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57720, ChEBI:CHEBI:142355; EC=2.4.2.1;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000477};
CC   -!- PATHWAY: Purine metabolism; purine nucleoside salvage.
CC       {ECO:0000256|PIRNR:PIRNR000477}.
CC   -!- SIMILARITY: Belongs to the PNP/MTAP phosphorylase family.
CC       {ECO:0000256|PIRNR:PIRNR000477}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85507.1}.
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DR   EMBL; AAHF01000012; EAL85507.1; -; Genomic_DNA.
DR   RefSeq; XP_747545.1; XM_742452.1.
DR   STRING; 746128.CADAFUBP00009033; -.
DR   EnsemblFungi; EAL85507; EAL85507; AFUA_6G05320.
DR   GeneID; 3505190; -.
DR   KEGG; afm:AFUA_6G05320; -.
DR   EuPathDB; FungiDB:Afu6g05320; -.
DR   HOGENOM; HOG000045183; -.
DR   InParanoid; Q4WDN1; -.
DR   KO; K03783; -.
DR   OMA; EGVYAQF; -.
DR   OrthoDB; 1078969at2759; -.
DR   UniPathway; UPA00606; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004731; F:purine-nucleoside phosphorylase activity; IBA:GO_Central.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR011270; Pur_Nuc_Pase_Ino/Guo-sp.
DR   InterPro; IPR011268; Purine_phosphorylase.
DR   InterPro; IPR018099; Purine_phosphorylase-2_CS.
DR   PANTHER; PTHR11904; PTHR11904; 1.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   PIRSF; PIRSF000477; PurNPase; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   TIGRFAMs; TIGR01700; PNPH; 1.
DR   TIGRFAMs; TIGR01697; PNPH-PUNA-XAPA; 1.
DR   PROSITE; PS01240; PNP_MTAP_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WDN1.
DR   SWISS-2DPAGE; Q4WDN1.
KW   Glycosyltransferase {ECO:0000256|PIRNR:PIRNR000477,
KW   ECO:0000313|EMBL:EAL85507.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000477, ECO:0000313|EMBL:EAL85507.1}.
FT   DOMAIN          34..313
FT                   /note="PNP_UDP_1"
FT                   /evidence="ECO:0000259|Pfam:PF01048"
FT   REGION          95..97
FT                   /note="Phosphate binding"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
FT   BINDING         41
FT                   /note="Phosphate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
FT   BINDING         74
FT                   /note="Phosphate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
FT   BINDING         127
FT                   /note="Phosphate; via amide nitrogen"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
FT   BINDING         215
FT                   /note="Purine nucleoside"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
FT   BINDING         234
FT                   /note="Phosphate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
FT   BINDING         257
FT                   /note="Purine nucleoside"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000477-2"
SQ   SEQUENCE   320 AA;  35184 MW;  6F6B92D33C960A3F CRC64;
     MLPEAPKNKS LYEEAVEAFS FLKERLPETL QHPRVAVICG SGLGGLANTI HDEPRAEFEY
     SSIPHFPCLT VPGHAGKLVF GLLADHIPVV LMVGRAHYYE GHSIHQVTFP IRVFKLLGIE
     TIVLTNAAGG LNTEYAVGDI VIINDHIFPA GFAGTHPLRG PNTEEFGPRF PPLSDAYDLE
     LRRHAHQAWK AVISENSTRR LHEGVYAFVA GPSYETRAEC RMLRQVGADL VGMSTVPEII
     VARHCGIRVL AFSLVTNKAV LSPVPRGDDH LLQAKDVKEL DSILQEGKAN HEEVLEAGRT
     AAIDMQKLVV RVISNVHGRR
//

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