(data stored in SCRATCH zone)

SWISSPROT: Q4WNH0_ASPFU

ID   Q4WNH0_ASPFU            Unreviewed;      1508 AA.
AC   Q4WNH0;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 109.
DE   SubName: Full=Rho GTPase activator (Bem3), putative {ECO:0000313|EMBL:EAL88494.1};
GN   ORFNames=AFUA_6G06400 {ECO:0000313|EMBL:EAL88494.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL88494.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL88494.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL88494.1}.
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DR   EMBL; AAHF01000006; EAL88494.1; -; Genomic_DNA.
DR   RefSeq; XP_750532.1; XM_745439.1.
DR   STRING; 746128.CADAFUBP00007040; -.
DR   EnsemblFungi; EAL88494; EAL88494; AFUA_6G06400.
DR   GeneID; 3508137; -.
DR   KEGG; afm:AFUA_6G06400; -.
DR   EuPathDB; FungiDB:Afu6g06400; -.
DR   HOGENOM; HOG000181676; -.
DR   InParanoid; Q4WNH0; -.
DR   KO; K08773; -.
DR   OMA; HNAQLWR; -.
DR   OrthoDB; 625432at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0043087; P:regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.1520.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
DR   PRODOM; Q4WNH0.
DR   SWISS-2DPAGE; Q4WNH0.
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          849..966
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1151..1367
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          901..921
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1473..1508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..139
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..190
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..357
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..398
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..436
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..510
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..578
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..603
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        614..650
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        901..918
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        969..1000
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1034..1048
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1479..1496
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1508 AA;  165175 MW;  2523C9EC416ED2BD CRC64;
     MSQLRHGSDN NPSLNQPSAV YPVSQQARDA GFPRSPLTGS LIPRDYLVTR ADAQPLRSGV
     VAVTDPSKPM PSPLNTSDHC RENRQDNSSV LQSPVSPRSS VKTAPPPNHS STSRIVHAPS
     PSKPSGSGQE STTSSAGDRV CGDPKQHDRG VIAIANDIGA RKLSDTGDSV QSPTSSPVSL
     LDSLQSMSGD RTPGHRIMPR TSSIDSAISS LSSASQPHKS SFDASAVSQA DIDRLIATAG
     STEAVIIHLL KEKHHAASQN AQLWRLVDKQ RTLILGLNKD LERALKEKER YKKRAKELQN
     SIPPVPPTND HIVQSRSADT SAIPASRDLS KQEQAQGESS EAKSTNAGMQ DLCDSSVLSP
     NAKVDRRSPA GADSPRLNTT FDNEFSRPGQ IEELDQQSNS QSLAYARKEM LSASPTSLAS
     SSSALNETLP SEESQQRLPH PSRKPPPAPL KLGQTQRVAM ENSGNYDSES DYEDILEVDE
     LPVERGRRKT RDDDDREREA ALDKEMGALK ATGEEPPQTC DPSHLLGKTP TGGLTAGVSK
     DLWQPISSSS PIERQDSLNS AQNPQKIHAP SLNDQSAFAV PKSPGLPLSP RPEDRPIGSP
     LPRMPREVPN SLAHLPMSSE NSLAGLALSP RPTNHPNPSA TGASKPNDTS PSHIDAHRHI
     ATINHGSRKD TPRSHWSPAR EIYQGLMSED YPGLLLPPNA LPLIRVKVSS SRLRPSRNSY
     LAPKPSEEEP VFTLGVFSRS ENLELWRVEK VVAALPQLDQ QIRQSSALWM KLPDRSIFSG
     HSPAKIDARR AALNSYFEAL LDTPVDERAA LAICQFLTMD AIEPRDDESS LLKGNCKAAS
     EVLPGQDRKP QKEGYLAKRG KNFGGWKTRY FILYGPELKY FESPGGPHLG TIKIFNAQIG
     KQSQPANNTN NPLSGPEDDS ENQYRHAFLI LEPKRKDSSA LVRHVLCAES DEERDAWVEA
     LLAYVDGQSD NEGTENASPQ SQVSTQARHL SQSTSKPKLF AGGSKKSGKG MNNADADLTD
     TVQGFSYDDA VPAEPPLLGP PSEKQPPRSP MSPLEAAMEP SDTNPASDHV QLSSKVISGP
     TNGTVIQDAG AWGNKTVTTT KEKKRSIWGF RTRSSYDLAS QLQASQEPSS AQAVVNPSTE
     RKDLVRPVFG IPLAEAVQHC APHGIDVDLP AVVYRCIEYL KAKGAATEEG IFRLSGSNVV
     VKALKERFNT EGDVDFLAGD EYYDVHAVAS LFKQYLRELP TTVLTRELHL DFLRVLGACR
     CFPSFLHLFQ GTILIKSYLE LDERQKKILA FNSLVHRLPR PNLALLRALV QFLIIIINNS
     DVNKMTIRNV GIVFAPTLNI PAPVFSMFLT DFESIFDKMP EGCSEPVELK VDRPALPEDI
     RSPRHQMFSD LPTPAYSQTT FRRPTEVVDD SRHDTGFISI QPTYEQSSHN LVEHYNQQPD
     SAAMNRMLMP SVDSSRSAKA KRRESSMLFM EYNHQDSGLP AMRNDQSKSP PITPELSHRL
     QTDLRESR
//

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