(data stored in SCRATCH zone)

SWISSPROT: Q4WNM7_ASPFU

ID   Q4WNM7_ASPFU            Unreviewed;       467 AA.
AC   Q4WNM7;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   SubName: Full=Longevity-assurance protein (LAC1), putative {ECO:0000313|EMBL:EAL90157.1};
GN   ORFNames=AFUA_4G06290 {ECO:0000313|EMBL:EAL90157.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL90157.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL90157.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL90157.1}.
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DR   EMBL; AAHF01000005; EAL90157.1; -; Genomic_DNA.
DR   RefSeq; XP_752195.1; XM_747102.1.
DR   STRING; 746128.CADAFUBP00006166; -.
DR   EnsemblFungi; EAL90157; EAL90157; AFUA_4G06290.
DR   GeneID; 3509004; -.
DR   KEGG; afm:AFUA_4G06290; -.
DR   EuPathDB; FungiDB:Afu4g06290; -.
DR   HOGENOM; HOG000187874; -.
DR   InParanoid; Q4WNM7; -.
DR   KO; K04709; -.
DR   OMA; CEQRISR; -.
DR   OrthoDB; 987268at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0050291; F:sphingosine N-acyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR016439; Lag1/Lac1-like.
DR   InterPro; IPR006634; TLC-dom.
DR   InterPro; IPR013599; TRAM1.
DR   PANTHER; PTHR12560; PTHR12560; 1.
DR   Pfam; PF08390; TRAM1; 1.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   PIRSF; PIRSF005225; LAG1_LAC1; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   4: Predicted;
DR   PRODOM; Q4WNM7.
DR   SWISS-2DPAGE; Q4WNM7.
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU00205,
KW   ECO:0000256|SAAS:SAAS00565877, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00205,
KW   ECO:0000256|SAAS:SAAS00565894, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00565882,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        112..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        227..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        357..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          137..386
FT                   /note="TLC"
FT                   /evidence="ECO:0000259|PROSITE:PS50922"
FT   REGION          390..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  53868 MW;  B925B84082FC3BBA CRC64;
     MAKDESTRSQ SVSELNTCVS TSHRTAAKDA TFREWMDANQ IGMRLFSNLP WSWTRWLTVA
     LYAYLGVSLT ILGTLLAAHN LYPTLRPYTA PFFELSYYQP SEGVYVQGFD DVYFVVSSAI
     TFTAVRAIAI EWIFRPAARY AGLKRKASNR FAEQAWMWMY YAFFWTFGMY IWTNSYYWMD
     FKAIWAQWPA RGISANLKWY LLAQLSFWFQ QILVINMEER RKDHYQMLTH HIITSTLLTS
     AYIYGFYNVS NVVLCLMDIV DLLLPTAKIL KYFKFELCCN ITFGLFMVTW LITRHIFYPL
     LCWSIYKDVP DAMAYGCYSG STAEMISTDG YPNRFRYLFN PFLDINGPIC MNRTVKWIFL
     GFLLALQLLS LIWFVMVVRV AVNVLRTGNA EDTRSDGEEE EEEVEVRPVG KDALNNNPVG
     VDGANADWRR ASSGSASVRP RARGRIPLGD QSDRKALLGR IGCDKPT
//

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