(data stored in SCRATCH zone)

SWISSPROT: Q4ZZL6_PSEU2

ID   Q4ZZL6_PSEU2            Unreviewed;       128 AA.
AC   Q4ZZL6;
DT   07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2005, sequence version 1.
DT   08-MAY-2019, entry version 77.
DE   RecName: Full=L-ectoine synthase {ECO:0000256|HAMAP-Rule:MF_01255};
DE            EC=4.2.1.108 {ECO:0000256|HAMAP-Rule:MF_01255};
DE   AltName: Full=N-acetyldiaminobutyrate dehydratase {ECO:0000256|HAMAP-Rule:MF_01255};
GN   Name=ectC {ECO:0000256|HAMAP-Rule:MF_01255};
GN   OrderedLocusNames=Psyr_0334 {ECO:0000313|EMBL:AAY35406.1};
OS   Pseudomonas syringae pv. syringae (strain B728a).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX   NCBI_TaxID=205918 {ECO:0000313|EMBL:AAY35406.1, ECO:0000313|Proteomes:UP000000426};
RN   [1] {ECO:0000313|EMBL:AAY35406.1, ECO:0000313|Proteomes:UP000000426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B728a {ECO:0000313|EMBL:AAY35406.1,
RC   ECO:0000313|Proteomes:UP000000426};
RX   PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA   Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA   Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA   Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA   Kyrpides N.C., Ivanova N., Lindow S.E.;
RT   "Comparison of the complete genome sequences of Pseudomonas syringae
RT   pv. syringae B728a and pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC   -!- FUNCTION: Catalyzes the circularization of gamma-N-acetyl-
CC       alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-
CC       tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an
CC       excellent osmoprotectant. {ECO:0000256|HAMAP-Rule:MF_01255}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2S)-4-acetamido-2-aminobutanoate = H2O + L-ectoine;
CC         Xref=Rhea:RHEA:17281, ChEBI:CHEBI:15377, ChEBI:CHEBI:58515,
CC         ChEBI:CHEBI:58929; EC=4.2.1.108; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01255};
CC   -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis;
CC       L-ectoine from L-aspartate 4-semialdehyde: step 3/3.
CC       {ECO:0000256|HAMAP-Rule:MF_01255}.
CC   -!- SIMILARITY: Belongs to the ectoine synthase family.
CC       {ECO:0000256|HAMAP-Rule:MF_01255}.
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DR   EMBL; CP000075; AAY35406.1; -; Genomic_DNA.
DR   RefSeq; WP_003403190.1; NC_007005.1.
DR   RefSeq; YP_233444.1; NC_007005.1.
DR   STRING; 205918.Psyr_0334; -.
DR   EnsemblBacteria; AAY35406; AAY35406; Psyr_0334.
DR   GeneID; 3365810; -.
DR   KEGG; psb:Psyr_0334; -.
DR   PATRIC; fig|205918.7.peg.340; -.
DR   eggNOG; ENOG4108Z6K; Bacteria.
DR   eggNOG; ENOG4111NEJ; LUCA.
DR   HOGENOM; HOG000078059; -.
DR   KO; K06720; -.
DR   OMA; DKHDKHY; -.
DR   BioCyc; PSYR205918:G1G4J-335-MONOMER; -.
DR   UniPathway; UPA00067; UER00123.
DR   Proteomes; UP000000426; Chromosome.
DR   GO; GO:0033990; F:ectoine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019491; P:ectoine biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_01255; Ectoine_synth; 1.
DR   InterPro; IPR010462; Ectoine_synth.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR39289; PTHR39289; 1.
DR   Pfam; PF06339; Ectoine_synth; 1.
DR   ProDom; PD080544; Ectoine_synth; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4ZZL6.
DR   SWISS-2DPAGE; Q4ZZL6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000426};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_01255, ECO:0000313|EMBL:AAY35406.1}.
SQ   SEQUENCE   128 AA;  14493 MW;  A1D5B69A18441637 CRC64;
     MFVRNKTDVE NTPYFVEWGA GTSHRLLTER DAMGFTLCHT IVRAGTESLL HYRNHLEACY
     CIGGEGEVED MQGNVFPIRP GDVYVLDQHD RHFLRGGKEQ DLILVSVFNP PLRGDERHNL
     NDGTGSAY
//

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