(data stored in ACNUC1829 zone)

SWISSPROT: Q58CZ7_BOVIN

ID   Q58CZ7_BOVIN            Unreviewed;       232 AA.
AC   Q58CZ7;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   07-JUN-2017, entry version 86.
DE   RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN   Name=TSPAN2 {ECO:0000313|EMBL:AAX46647.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000021222};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000313|EMBL:AAX46647.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pooled {ECO:0000313|EMBL:AAX46647.1};
RX   PubMed=11282978; DOI=10.1101/gr.170101;
RA   Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T.,
RA   Casas E., Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L.,
RA   Heaton M.P., Laegreid W.W., Rohrer G.A., Chitko-McKown C.G.,
RA   Pertea G., Holt I., Karamycheva S., Liang F., Quackenbush J.,
RA   Keele J.W.;
RT   "Sequence evaluation of four pooled-tissue normalized bovine cDNA
RT   libraries and construction of a gene index for cattle.";
RL   Genome Res. 11:626-630(2001).
RN   [2] {ECO:0000313|EMBL:AAX46647.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pooled {ECO:0000313|EMBL:AAX46647.1};
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000021222, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021222,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [4] {ECO:0000313|Ensembl:ENSBTAP00000021222}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021222};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361218};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000256|RuleBase:RU361218, ECO:0000256|SAAS:SAAS00545671}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361218}.
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DR   EMBL; DAAA02007446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02007447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02007448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02007449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02007450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BT021800; AAX46647.1; -; mRNA.
DR   RefSeq; NP_001029829.1; NM_001034657.1.
DR   RefSeq; XP_015318843.1; XM_015463357.1.
DR   UniGene; Bt.53492; -.
DR   STRING; 9913.ENSBTAP00000021222; -.
DR   Ensembl; ENSBTAT00000021222; ENSBTAP00000021222; ENSBTAG00000015961.
DR   GeneID; 539001; -.
DR   KEGG; bta:539001; -.
DR   CTD; 10100; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00880000137858; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG002324; -.
DR   KO; K17354; -.
DR   OMA; HSAFQCC; -.
DR   OrthoDB; EOG091G0K9H; -.
DR   TreeFam; TF352895; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000015961; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
DR   GO; GO:0014002; P:astrocyte development; IEA:Ensembl.
DR   GO; GO:0061564; P:axon development; IEA:Ensembl.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0014005; P:microglia development; IEA:Ensembl.
DR   GO; GO:0042552; P:myelination; IEA:Ensembl.
DR   GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q58CZ7.
DR   SWISS-2DPAGE; Q58CZ7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00027997};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00429797};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361218,
KW   ECO:0000256|SAAS:SAAS00028005}.
FT   TRANSMEM     12     34       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     54     75       Helical. {ECO:0000256|RuleBase:RU361218}.
FT   TRANSMEM     87    111       Helical. {ECO:0000256|RuleBase:RU361218}.
SQ   SEQUENCE   232 AA;  25673 MW;  9C5755C803556E64 CRC64;
     MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG SMKDFSSEDK SPEYFYMGLY
     VLVGAGALMM AVGFFGCCGA TRESQCVLGS FFTCLLVIFA AEITTGVFAF IGKDVAIRHV
     QTMYEEAYND YLRDKEKGNG TLITFHSTFQ CCGKESPEQV QPTCPKELLG HKNCIDEIES
     IISVKLQLIG IVGIGIAGLT IQRECYNPAA LSVHVIKQYE NPKTQINIWS SS
//

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