(data stored in ACNUC12215 zone)

SWISSPROT: XKR2_MOUSE

ID   XKR2_MOUSE              Reviewed;         449 AA.
AC   Q5GH68; A2AEK6;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   08-MAY-2019, entry version 81.
DE   RecName: Full=XK-related protein 2;
DE   AltName: Full=X Kell blood group-related, X-linked;
GN   Name=Xkrx; Synonyms=Xkr2, Xrg2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in
RT   vertebrates and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
DR   EMBL; AY534249; AAT07098.1; -; mRNA.
DR   EMBL; AL671915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150896; AAI50897.1; -; mRNA.
DR   EMBL; BC150897; AAI50898.1; -; mRNA.
DR   CCDS; CCDS30391.1; -.
DR   RefSeq; NP_899142.2; NM_183319.2.
DR   STRING; 10090.ENSMUSP00000033611; -.
DR   iPTMnet; Q5GH68; -.
DR   PhosphoSitePlus; Q5GH68; -.
DR   EPD; Q5GH68; -.
DR   PaxDb; Q5GH68; -.
DR   PRIDE; Q5GH68; -.
DR   Ensembl; ENSMUST00000033611; ENSMUSP00000033611; ENSMUSG00000031258.
DR   GeneID; 331524; -.
DR   KEGG; mmu:331524; -.
DR   UCSC; uc009ufo.1; mouse.
DR   CTD; 402415; -.
DR   MGI; MGI:3584011; Xkrx.
DR   eggNOG; ENOG410IJ21; Eukaryota.
DR   eggNOG; ENOG4110US3; LUCA.
DR   GeneTree; ENSGT00390000003231; -.
DR   HOGENOM; HOG000118070; -.
DR   InParanoid; Q5GH68; -.
DR   OMA; GQEEPYV; -.
DR   OrthoDB; 768086at2759; -.
DR   PhylomeDB; Q5GH68; -.
DR   TreeFam; TF331465; -.
DR   PRO; PR:Q5GH68; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   Bgee; ENSMUSG00000031258; Expressed in 47 organ(s), highest expression level in ear.
DR   Genevisible; Q5GH68; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q5GH68.
DR   SWISS-2DPAGE; Q5GH68.
KW   Complete proteome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    449       XK-related protein 2.
FT                                /FTId=PRO_0000190773.
FT   TRANSMEM     35     55       Helical. {ECO:0000255}.
FT   TRANSMEM     68     88       Helical. {ECO:0000255}.
FT   TRANSMEM     98    118       Helical. {ECO:0000255}.
FT   TRANSMEM    174    194       Helical. {ECO:0000255}.
FT   TRANSMEM    204    224       Helical. {ECO:0000255}.
FT   TRANSMEM    241    261       Helical. {ECO:0000255}.
FT   TRANSMEM    269    289       Helical. {ECO:0000255}.
FT   TRANSMEM    306    326       Helical. {ECO:0000255}.
FT   TRANSMEM    357    377       Helical. {ECO:0000255}.
FT   TRANSMEM    382    402       Helical. {ECO:0000255}.
SQ   SEQUENCE   449 AA;  51778 MW;  0FD7BFCDE2A87EF7 CRC64;
     MDRVYEIPEE PNVVPISSLE EDVIRGPNPR FTFPFSILFS TFLYCGEAAS ALYMVRIYRK
     NNETFWMTYT FSFFMFSSIM VQLTLIFVHR DLAKDRPLSL FMHLILLGPV IRCLEAMIKY
     LTLWKKEGQE EPYVSLTRKK MLIAGQEVLI EWEVGHSIRT LAMHRNAYKR MSQIQAFLGS
     VPQLTYQLYV SLISAEVPLG RAVLMAFSLI SVTYGATLCN MLAIQIKYDD YKIRLGPLEV
     LCITVWRTLE ITSRLVILVL FSATLKLKAV PFLVLNFLII LFEPWVKFWR SGAQMPNNIE
     KNFSRVGTLV VLISVTILYA GINFSCWSAM QLKLADRDLV DKGQNWGHMG LHYSVRLVEN
     VIMVLVFKYF GVKVLLNYCH SLIAVQLIIA YLISIGVMLL FFQYLHPLRS LFTNNVVDYL
     HCICCRRPRP ERVENSETSC EADTTQSIV
//

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