(data stored in ACNUC22857 zone)

SWISSPROT: Q5KDA3_CRYNJ

ID   Q5KDA3_CRYNJ            Unreviewed;       755 AA.
AC   Q5KDA3;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   07-JUN-2017, entry version 75.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   OrderedLocusNames=CNH03830 {ECO:0000313|EMBL:AAW45234.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 /
OS   ATCC MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45234.1, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW45234.1, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Adaptins are components of the adaptor complexes which
CC       link clathrin to receptors in coated vesicles. Clathrin-associated
CC       protein complexes are believed to interact with the cytoplasmic
CC       tails of membrane proteins, leading to their selection and
CC       concentration. {ECO:0000256|PIRNR:PIRNR002291}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; AE017348; AAW45234.1; -; Genomic_DNA.
DR   RefSeq; XP_572541.1; XM_572541.1.
DR   ProteinModelPortal; Q5KDA3; -.
DR   STRING; 214684.XP_572541.1; -.
DR   PaxDb; Q5KDA3; -.
DR   EnsemblFungi; AAW45234; AAW45234; CNH03830.
DR   GeneID; 3259143; -.
DR   KEGG; cne:CNH03830; -.
DR   EuPathDB; FungiDB:CNH03830; -.
DR   eggNOG; KOG1061; Eukaryota.
DR   eggNOG; COG5096; LUCA.
DR   HOGENOM; HOG000163270; -.
DR   InParanoid; Q5KDA3; -.
DR   OMA; NAVENPI; -.
DR   OrthoDB; EOG092C18N0; -.
DR   Proteomes; UP000002149; Chromosome 8.
DR   GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   PANTHER; PTHR11134; PTHR11134; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q5KDA3.
DR   SWISS-2DPAGE; Q5KDA3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002149};
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00101884};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00468902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291,
KW   ECO:0000256|SAAS:SAAS00299740}.
FT   DOMAIN       10    548       Adaptin_N. {ECO:0000259|Pfam:PF01602}.
SQ   SEQUENCE   755 AA;  82628 MW;  E1A44530BF9E3579 CRC64;
     MAMAPPRKGE NWELRQQLNS EYRDKRADAI KRVIANHTIG KDCSGLFPDV VKNMQTDDLE
     QKKLVYLYLM NYAKTQPELV ILAVNTFVKD TADPNPLVRA LAIRTMSILR AEKILDYLAS
     PLSRCLKDEN PYVRKTAALC VAKVFDLKPE LAIEYGFIET LRDLIGDGNP MVVANAVAAL
     GDIHEASLNL PSSQPGSPND DESPSSVRPN QSLFIIDPAT LTKLLVALNE CSEWGRIAIL
     TTLARYRTND EKESEHICER VMPQFQHVNA AVVLGAVKVI MIHMKNVTKE DLLKSLTRKM
     APPLVTLISS PPEVQWVALR NINLLLQKRP DILASEMRVF FCKYNDPSYV KVEKLEIMVR
     LANEKNVDTL LGELKEYASE VDVDFVRKAV RAVGQVAIKI DEAAGRCVEV LMELIETRVS
     YVVQEAVIVV KDIFRKYPHS YEGIIPALCA NLEELDEXEA KASLIWLIGE YAEKIENADE
     LLGAFLETFS EESYPVQLQT LTAIVKLFLK KPDESQAIVQ KVLQAATKDC DSPDVRDRAY
     IYWRLLSSDP AAAKSVVLSV RPPISLPQTT VAPAILEELI GEISTLASVY HKPAATFIGK
     GRLGADEMHK KSLDAEDDVS REKALQAVVA GNQAENLLDF DDEPTPTNGE SSIPAPGAGL
     GISSQAIASA AKSTNPLDEL MDLFSTASMT TPVVQPGQPA AQAQTSAQSS GGLGGLNGLA
     GLSSPPQSVS PQPGAPQSQK QQQQAAAQDD LLGLF
//

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