(data stored in ACNUC8465 zone)

SWISSPROT: Q5KN75_CRYNJ

ID   Q5KN75_CRYNJ            Unreviewed;       609 AA.
AC   Q5KN75; Q55YV7;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   11-DEC-2019, entry version 111.
DE   SubName: Full=MAP kinase kinase, putative {ECO:0000313|EMBL:AAW41278.1};
GN   OrderedLocusNames=CNA07470 {ECO:0000313|EMBL:AAW41278.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW41278.1, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW41278.1, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
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DR   EMBL; AE017341; AAW41278.1; -; Genomic_DNA.
DR   RefSeq; XP_567097.1; XM_567097.1.
DR   STRING; 5207.AAW41278; -.
DR   PaxDb; Q5KN75; -.
DR   EnsemblFungi; AAW41278; AAW41278; CNA07470.
DR   GeneID; 3253574; -.
DR   KEGG; cne:CNA07470; -.
DR   EuPathDB; FungiDB:CNA07470; -.
DR   eggNOG; KOG0581; Eukaryota.
DR   eggNOG; ENOG410XQ5A; LUCA.
DR   HOGENOM; HOG000234206; -.
DR   InParanoid; Q5KN75; -.
DR   KO; K11227; -.
DR   OMA; GYNTKQQ; -.
DR   OrthoDB; 688282at2759; -.
DR   Proteomes; UP000002149; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
DR   PRODOM; Q5KN75.
DR   SWISS-2DPAGE; Q5KN75.
KW   Kinase {ECO:0000313|EMBL:AAW41278.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW   Transferase {ECO:0000313|EMBL:AAW41278.1}.
FT   DOMAIN          295..569
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..78
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   609 AA;  64092 MW;  D4649C66996E6BCB CRC64;
     MTDPTPPALD SLSLADKAPA AEENPRDAAE QPKPAASPPA GTPVDDAQSS SASPSQRPPS
     IQANDKAPGT SSPAARPQAQ HVPASAPTVP SANPVRPQPG ARPGVARGMP APMGMRAQAV
     RGAGGPQMQT KMLPSLQAKM DKIAASRQGP PPSSGMHDPN ATSMGALLRS QALRAPGTSQ
     APPGPGPASG PFGLAARRAA AGGPPRPNLG MMGMGASAPS AVGRGPGLAG RRGPPGGLTL
     SGMKGAIKDD GNKFSDFQGV MDPSGSLRFS KKAVLHAKGV DFDDGQSFKI NMDEIEVLGE
     LGKGNYGSVH KVFHRPTGVT MAMKEIRLEL DDSKLNGIIM ELDILHRAVA PEIVEFYGAF
     TIESCVYYCM EYMDAGSLDS LTGGGVAAKD QTKEEEDDAT ERVPEDVLRR ITARIVKGLR
     FLKDELQIIH RDVKPTNVLI NGKGEVKMCD FGVSGQLEKS LAKTNIGCQS YMAPERIKSE
     TANQNPTYTV SSDVWSVGLS IVELAKGCYP YPPETYANVF AQLQAIVHGT PPTLPPGYSD
     DANDFVAKCL EKDPNRRPTY AQLLEHPFLV ADKGAEVDMV GWVEGALKRK AERGIASLNP
     IQTPAPLEP
//

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