(data stored in SCRATCH zone)

SWISSPROT: Q5LWF5_RUEPO

ID   Q5LWF5_RUEPO            Unreviewed;       354 AA.
AC   Q5LWF5;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   08-MAY-2019, entry version 103.
DE   RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081, ECO:0000256|SAAS:SAAS00923500};
GN   Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN   ECO:0000313|EMBL:AAV93340.1};
GN   OrderedLocusNames=SPO0009 {ECO:0000313|EMBL:AAV93340.1};
OS   Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
OS   (Silicibacter pomeroyi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Ruegeria.
OX   NCBI_TaxID=246200 {ECO:0000313|EMBL:AAV93340.1, ECO:0000313|Proteomes:UP000001023};
RN   [1] {ECO:0000313|EMBL:AAV93340.1, ECO:0000313|Proteomes:UP000001023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=15602564; DOI=10.1038/nature03170;
RA   Moran M.A., Buchan A., Gonzalez J.M., Heidelberg J.F., Whitman W.B.,
RA   Kiene R.P., Henriksen J.R., King G.M., Belas R., Fuqua C., Brinkac L.,
RA   Lewis M., Johri S., Weaver B., Pai G., Eisen J.A., Rahe E.,
RA   Sheldon W.M., Ye W., Miller T.R., Carlton J., Rasko D.A.,
RA   Paulsen I.T., Ren Q., Daugherty S.C., Deboy R.T., Dodson R.J.,
RA   Durkin A.S., Madupu R., Nelson W.C., Sullivan S.A., Rosovitz M.J.,
RA   Haft D.H., Selengut J., Ward N.;
RT   "Genome sequence of Silicibacter pomeroyi reveals adaptations to the
RT   marine environment.";
RL   Nature 432:910-913(2004).
RN   [2] {ECO:0000313|EMBL:AAV93340.1, ECO:0000313|Proteomes:UP000001023}
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 700808 / DSM 15171 / DSS-3
RC   {ECO:0000313|Proteomes:UP000001023};
RX   PubMed=25780504; DOI=10.1186/1944-3277-9-11;
RA   Rivers A.R., Smith C.B., Moran M.A.;
RT   "An updated genome annotation for the model marine bacterium Ruegeria
RT   pomeroyi DSS-3.";
RL   Stand. Genomic Sci. 9:11-11(2014).
CC   -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-
CC       dnaK-dnaJ and groELS operons). Prevents heat-shock induction of
CC       these operons. {ECO:0000256|HAMAP-Rule:MF_00081,
CC       ECO:0000256|SAAS:SAAS00468649}.
CC   -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00081, ECO:0000256|SAAS:SAAS00577698}.
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DR   EMBL; CP000031; AAV93340.1; -; Genomic_DNA.
DR   RefSeq; WP_011045781.1; NC_003911.12.
DR   STRING; 246200.SPO0009; -.
DR   DNASU; 3195247; -.
DR   EnsemblBacteria; AAV93340; AAV93340; SPO0009.
DR   KEGG; sil:SPO0009; -.
DR   eggNOG; ENOG4105CI8; Bacteria.
DR   eggNOG; COG1420; LUCA.
DR   HOGENOM; HOG000058933; -.
DR   KO; K03705; -.
DR   OMA; GPKRMDY; -.
DR   OrthoDB; 1510750at2; -.
DR   BioCyc; RPOM246200:G1G48-9-MONOMER; -.
DR   Proteomes; UP000001023; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.390.60; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   HAMAP; MF_00081; HrcA; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR002571; HrcA.
DR   InterPro; IPR021153; HrcA_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR   PANTHER; PTHR34824; PTHR34824; 1.
DR   Pfam; PF01628; HrcA; 1.
DR   PIRSF; PIRSF005485; HrcA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00331; hrcA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q5LWF5.
DR   SWISS-2DPAGE; Q5LWF5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001023};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00468658};
KW   Stress response {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00468629};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00468662};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00081,
KW   ECO:0000256|SAAS:SAAS00468664}.
FT   DOMAIN      115    335       HrcA. {ECO:0000259|Pfam:PF01628}.
SQ   SEQUENCE   354 AA;  38979 MW;  F9BFDA7C7E5BEE0B CRC64;
     MSDARKILDD LNDRSREVFR LIVESYLDSG EPVGSRTLTR TLSEKVSAAT VRNVMQDLEF
     LGLLDSPHIS AGRIPTQMGL RMFVDGLLEV ADLSLDDRAK LDATLGTNAG DVGGTLDRIS
     ATLSRVTQGA SLVLTPKHEA EIRHIEFVSL AQDRALVVLV FSDGHVENRL FAPPPGQTPS
     SMREAANFLN ALIEGKTLSE VRRLMQTEIG ARQQEIDQLA RQMVESGLAV WDREGEEAAR
     LIVRGRANLL EGTGQEQELE RIRVLFDDLE RKRDIAEFLQ LTEDGEGVRI FIGSENKLFS
     LSGSSLVVSP YMNADRKVIG AVGVIGPTRL NYGRIVPIVD YTAQLVGRLI SDRS
//

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