(data stored in ACNUC9543 zone)

SWISSPROT: Q5TR49_ANOGA

ID   Q5TR49_ANOGA            Unreviewed;       673 AA.
AC   Q5TR49;
DT   07-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   23-OCT-2007, sequence version 3.
DT   08-MAY-2019, entry version 103.
DE   SubName: Full=AGAP006138-PA {ECO:0000313|EMBL:EAL40015.3};
DE   SubName: Full=ATP-dependent RNA helicase DHX33 {ECO:0000313|VectorBase:AGAP006138-PA};
GN   Name=1276808 {ECO:0000313|VectorBase:AGAP006138-PA};
GN   ORFNames=AgaP_AGAP006138 {ECO:0000313|EMBL:EAL40015.3};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:EAL40015.3, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EMBL:EAL40015.3, ECO:0000313|Proteomes:UP000007062, ECO:0000313|VectorBase:AGAP006138-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40015.3,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B.,
RA   Lai Z., Kraft C.L., Abril J.F., Anthouard V., Arensburger P.,
RA   Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V.,
RA   Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S.,
RA   Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M.,
RA   Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I.,
RA   Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z.,
RA   Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R.,
RA   Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E.,
RA   Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F.,
RA   Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R.,
RA   Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C.,
RA   Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V.,
RA   Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D.,
RA   Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F.,
RA   Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S.,
RA   Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C.,
RA   Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EMBL:EAL40015.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40015.3};
RG   The Anopheles Genome Sequencing Consortium;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EAL40015.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40015.3};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [4] {ECO:0000313|EMBL:EAL40015.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40015.3};
RX   PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA   Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA   Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT   "Update of the Anopheles gambiae PEST genome assembly.";
RL   Genome Biol. 8:R5-R5(2007).
RN   [5] {ECO:0000313|EMBL:EAL40015.3}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:EAL40015.3};
RG   VectorBase;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|VectorBase:AGAP006138-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|VectorBase:AGAP006138-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; AAAB01008960; EAL40015.3; -; Genomic_DNA.
DR   RefSeq; XP_556838.3; XM_556838.3.
DR   STRING; 7165.AGAP006138-PA; -.
DR   EnsemblMetazoa; AGAP006138-RA; AGAP006138-PA; AGAP006138.
DR   GeneID; 1276808; -.
DR   KEGG; aga:AgaP_AGAP006138; -.
DR   VectorBase; AGAP006138-RA; AGAP006138-PA; AGAP006138.
DR   eggNOG; KOG0922; Eukaryota.
DR   eggNOG; COG1643; LUCA.
DR   HOGENOM; HOG000175261; -.
DR   InParanoid; Q5TR49; -.
DR   KO; K17820; -.
DR   OMA; MDIDHFG; -.
DR   OrthoDB; 354219at2759; -.
DR   PhylomeDB; Q5TR49; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0034459; F:ATP-dependent 3'-5' RNA helicase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   CDD; cd00079; HELICc; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
DR   PRODOM; Q5TR49.
DR   SWISS-2DPAGE; Q5TR49.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01176619};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007062};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01176622};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01176608};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT   DOMAIN       43    211       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      228    407       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
SQ   SEQUENCE   673 AA;  75614 MW;  B548AF31BC0BC3F8 CRC64;
     MDSGLSSRNS SLGNQYSRSY MKQEQAKQQR LSLPIYSVRK SLMEMVRKSS TIIVLGETGS
     GKTTQMPQFI YEAGLNGDKM IAITQPRRVA AITVAKWVAQ EMGTNLGDLV GYTVRFEDMT
     SENTQVKYMT DGILCREALS DRQLRNYNVI ILDEVHERTI ATDVLLGVVK KAQQIRALKR
     MTPLKVIIMS ATMDCDHFAS YFSDCPIVYL QGRTYQVKVY QMVEKMHYIE ACLKTVVEIH
     QTQPAGDVLV FLTGQEEIEA TVGKMRRLAK SFSPDLPKLA VHPMYAALPQ NQQLDVFNAA
     PGNVRKVIFA TNIAETSITI NGIRYVVDCG RAKVRSYDPI TGMDMLKVSW ISQAQAHQRT
     GRAGRLSDGV CYRTYSKEVY GHLEKMTMPE ILRCNMAATI LNLLVMGVNY KDFDFIDKPP
     EEAIVGGLLE LKALNAISSV ENPILTALGT KMARFPLDPK YSKMLLSAPK FGCLEEMLTI
     IAMLSGENVF TNSVHKREQM LIAHSKFFDR SGDHITLLNV FNEFKTRAKP KVWCFDNFLN
     ERNLTHVASI REQLSEICKA LDLPSSTCGK DTTPVAKCLL TGLFANIATK QPDHLYLTST
     SALKARIHPS SAVCGKFRPP VVVYTELVAT RLNYLRNVTE IDPAWIDEVV PNVSQYQTKG
     FKENHFRAFQ SHK
//

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