(data stored in ACNUC18020 zone)

SWISSPROT: EDC3_CHICK

ID   EDC3_CHICK              Reviewed;         506 AA.
AC   Q5ZLS2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   08-MAY-2019, entry version 80.
DE   RecName: Full=Enhancer of mRNA-decapping protein 3;
DE   AltName: Full=YjeF domain-containing protein 1;
GN   Name=EDC3; Synonyms=YJDC; ORFNames=RCJMB04_5b1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Binds single-stranded RNA. Involved in the process of
CC       mRNA degradation and in the positive regulation of mRNA decapping
CC       (By similarity). {ECO:0000250|UniProtKB:Q96F86}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}.
CC       Note=Processing bodies (PB). {ECO:0000250}.
CC   -!- DOMAIN: The DFDF domain is unstructured by itself. It assumes a
CC       helical fold upon interaction with other proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EDC3 family. {ECO:0000305}.
DR   EMBL; AJ719662; CAG31321.1; -; mRNA.
DR   RefSeq; NP_001025556.1; NM_001030385.1.
DR   SMR; Q5ZLS2; -.
DR   STRING; 9031.ENSGALP00000002041; -.
DR   PaxDb; Q5ZLS2; -.
DR   GeneID; 415294; -.
DR   KEGG; gga:415294; -.
DR   CTD; 80153; -.
DR   eggNOG; KOG2585; Eukaryota.
DR   eggNOG; COG0062; LUCA.
DR   HOGENOM; HOG000231481; -.
DR   InParanoid; Q5ZLS2; -.
DR   KO; K12615; -.
DR   OrthoDB; 870769at2759; -.
DR   PhylomeDB; Q5ZLS2; -.
DR   PRO; PR:Q5ZLS2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:1990174; F:phosphodiesterase decapping endonuclease activity; ISS:UniProtKB.
DR   GO; GO:0033962; P:cytoplasmic mRNA processing body assembly; IBA:GO_Central.
DR   GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IBA:GO_Central.
DR   CDD; cd01737; LSm16_N; 1.
DR   Gene3D; 3.40.50.10260; -; 1.
DR   InterPro; IPR025762; DFDF.
DR   InterPro; IPR019050; FDF_dom.
DR   InterPro; IPR025609; Lsm14-like_N.
DR   InterPro; IPR034107; Lsm16_N.
DR   InterPro; IPR004443; YjeF_N_dom.
DR   InterPro; IPR036652; YjeF_N_dom_sf.
DR   Pfam; PF09532; FDF; 1.
DR   Pfam; PF12701; LSM14; 1.
DR   Pfam; PF03853; YjeF_N; 1.
DR   SMART; SM01199; FDF; 1.
DR   SMART; SM01271; LSM14; 1.
DR   SUPFAM; SSF64153; SSF64153; 1.
DR   PROSITE; PS51512; DFDF; 1.
DR   PROSITE; PS51385; YJEF_N; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q5ZLS2.
DR   SWISS-2DPAGE; Q5ZLS2.
KW   Complete proteome; Cytoplasm; Reference proteome; RNA-binding.
FT   CHAIN         1    506       Enhancer of mRNA-decapping protein 3.
FT                                /FTId=PRO_0000119058.
FT   DOMAIN      190    226       DFDF. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00845}.
FT   DOMAIN      281    485       YjeF N-terminal. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00719}.
FT   REGION        1     79       Required for P-body targeting and
FT                                interaction with DCP1A. {ECO:0000250}.
FT   REGION      189    294       Required for interaction with DDX6.
FT                                {ECO:0000250}.
SQ   SEQUENCE   506 AA;  56037 MW;  5A4566FACC512158 CRC64;
     MATDWLGSIV SINCGESLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP EVTFRAGDIT
     ELKILEIPGP GDSRQCGDLQ QADTGIPGVG CQVGPSQNGT GKMLKKPFSS SAPQNIPRRT
     DMKNQDIIIS PQQQCSKSYM DRHMETLSQS KGFRRRHNSW SSSSRHPNQV TPKKSGLKNG
     QMKSKDDECF GDDIDEIPDT DFDFEGNLAL FDKAAVFEEI ETYERRSGTR SRGTPNEKPA
     RYRHDENILE SEPIVYRRIV VPQNANKEFC TDSGLVVPSV SYELHKKLLS VAEKHGLTLE
     RRLEMTGVCA SQMALSLLGG PNRLNPKNVH QRPTVALLCG PHVKGAQGIS CGRHLSNHDV
     HVILFLPNFV KMLESITNEL NLFSSTQGQQ VSSVKDLPDT PVDLVINCLD CHENAFLRDQ
     PWYKAVVDWA NQNRAPVLSI DPPISEMEQG IDAKWSLALG LPLPLGERAG RVYLCDIGIP
     QKVFQEVGIN YHSPFGCKFV IPLHST
//

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