(data stored in ACNUC7421 zone)

SWISSPROT: TYPH_LEGPH

ID   TYPH_LEGPH              Reviewed;         517 AA.
AC   Q5ZWR3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   08-MAY-2019, entry version 86.
DE   RecName: Full=Putative thymidine phosphorylase {ECO:0000255|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000255|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase {ECO:0000255|HAMAP-Rule:MF_00703};
GN   OrderedLocusNames=lpg1022;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 /
OS   ATCC 33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M.,
RA   Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J.,
RA   Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R.,
RA   Pampou S., Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E.,
RA   Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G.,
RA   Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J.,
RA   Ju J., Kalachikov S., Shuman H.A., Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella
RT   pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-
CC         phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259;
CC         EC=2.4.2.4; Evidence={ECO:0000255|HAMAP-Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00703}.
DR   EMBL; AE017354; AAU27108.1; -; Genomic_DNA.
DR   RefSeq; WP_010946757.1; NC_002942.5.
DR   RefSeq; YP_095055.1; NC_002942.5.
DR   SMR; Q5ZWR3; -.
DR   STRING; 272624.lpg1022; -.
DR   PaxDb; Q5ZWR3; -.
DR   PRIDE; Q5ZWR3; -.
DR   EnsemblBacteria; AAU27108; AAU27108; lpg1022.
DR   GeneID; 19832587; -.
DR   KEGG; lpn:lpg1022; -.
DR   PATRIC; fig|272624.6.peg.1061; -.
DR   eggNOG; ENOG4105CMW; Bacteria.
DR   eggNOG; COG0213; LUCA.
DR   HOGENOM; HOG000252767; -.
DR   KO; K00758; -.
DR   OMA; QMVASIM; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0004645; F:phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom)sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; PTHR10515; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   PIRSF; PIRSF000478; TP_PyNP; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF47648; SSF47648; 1.
DR   SUPFAM; SSF52418; SSF52418; 1.
DR   SUPFAM; SSF54680; SSF54680; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q5ZWR3.
DR   SWISS-2DPAGE; Q5ZWR3.
KW   Complete proteome; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN         1    517       Putative thymidine phosphorylase.
FT                                /FTId=PRO_0000225647.
SQ   SEQUENCE   517 AA;  55296 MW;  3903064A69DFB546 CRC64;
     MHDSFLSANG GFVVSKKTPH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG FEVQTRIQVT
     LGSRSIIATL NVVTSELLQP GEAGLSDYAW ESLHAKEGDE IQVSHPKPLE SLSYVHAKIY
     GNELSFEQMK VIIDDVLSGR LSDVQISAFL AASGAGRLTR TEVMKLTKAM IDSGDRLSWP
     SPLVVDKHCV GGLPGNRTTL IVVPIVASFG LMIPKTSSRA ITSPAGTADT METLAPVHLS
     PQKMRQVVEQ ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH
     AVIDIPVGPT AKVRNQSMAL LLKQSLEEVG NELGLVVRAL FTDGSQPVGH GIGPSLEARD
     VLAVLQGLPD APNDLRERAL TLAGAALECS SKVPPGLGKS IATQLLESGQ AFKKFQAICE
     AQGGMRELTK ARFTYPVVAA KEGKVSLIDN RKLAKIAKLA GAPKSKSAGI DLHAHVGESV
     EQGEPLFTIH SESLGELHYA CDLLRDKQDI IILGENP
//

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