(data stored in ACNUC30309 zone)

SWISSPROT: RG1BB_DANRE

ID   RG1BB_DANRE             Reviewed;         475 AA.
AC   Q6DBW1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   08-MAY-2019, entry version 93.
DE   RecName: Full=Ras-GEF domain-containing family member 1B-B;
GN   Name=rasgef1bb {ECO:0000312|ZFIN:ZDB-GENE-040801-220};
GN   Synonyms=rasgef {ECO:0000303|PubMed:17239665}; ORFNames=zgc:91814;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH78340.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   DEVELOPMENTAL STAGE.
RX   PubMed=17239665; DOI=10.1016/j.modgep.2006.11.010;
RA   Epting D., Vorwerk S., Hageman A., Meyer D.;
RT   "Expression of rasgef1b in zebrafish.";
RL   Gene Expr. Patterns 7:389-395(2007).
CC   -!- FUNCTION: Guanine nucleotide exchange factor (GEF) for Ras family
CC       proteins. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout embryogenesis from the
CC       blastula sphere stage (4 hours post fertilization).
CC       {ECO:0000269|PubMed:17239665}.
DR   EMBL; BC078340; AAH78340.1; -; mRNA.
DR   RefSeq; NP_001003479.1; NM_001003479.1.
DR   SMR; Q6DBW1; -.
DR   STRING; 7955.ENSDARP00000064967; -.
DR   PaxDb; Q6DBW1; -.
DR   PRIDE; Q6DBW1; -.
DR   Ensembl; ENSDART00000064968; ENSDARP00000064967; ENSDARG00000044251.
DR   Ensembl; ENSDART00000182968; ENSDARP00000148041; ENSDARG00000117029.
DR   GeneID; 445085; -.
DR   KEGG; dre:445085; -.
DR   CTD; 445085; -.
DR   ZFIN; ZDB-GENE-040801-220; rasgef1bb.
DR   eggNOG; KOG3541; Eukaryota.
DR   eggNOG; ENOG410XRE3; LUCA.
DR   GeneTree; ENSGT00940000155816; -.
DR   HOGENOM; HOG000018026; -.
DR   InParanoid; Q6DBW1; -.
DR   OMA; RVFIHPH; -.
DR   OrthoDB; 533115at2759; -.
DR   PhylomeDB; Q6DBW1; -.
DR   TreeFam; TF313379; -.
DR   PRO; PR:Q6DBW1; -.
DR   Proteomes; UP000000437; Chromosome 10.
DR   Bgee; ENSDARG00000044251; Expressed in 28 organ(s), highest expression level in gastrula.
DR   GO; GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6DBW1.
DR   SWISS-2DPAGE; Q6DBW1.
KW   Complete proteome; Guanine-nucleotide releasing factor;
KW   Reference proteome.
FT   CHAIN         1    475       Ras-GEF domain-containing family member
FT                                1B-B.
FT                                /FTId=PRO_0000341486.
FT   DOMAIN       36    166       N-terminal Ras-GEF. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00135}.
FT   DOMAIN      209    456       Ras-GEF. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00168}.
SQ   SEQUENCE   475 AA;  55441 MW;  079290539F0DE7FD CRC64;
     MPQTTPYSSK FNPSAYSSSH SHRQPVEENY GGLHYRDNKL VSGSLEALIQ LLVPTVDYYP
     DRSYIFTFLL SSRLFLNPFE LMSRVCYLGV DHHRVGDPQM DKKRIRDIAP KIVQLLTEWT
     ETFPYDFRDE RMMRSLKEMT HRLAFGDELS RRAMQRLIQR LLRKLTTLGQ YEESLATTSA
     AAAIDRPVAL KSKQQLVRRD DCVLNLCDDP FIFAQQLTHI EMERLSYIGP EEFVRAFAQK
     RPSDNHKSFF SKRKASNLEA YVEWFNRLSY LTATEICMPV KKKHRARVLE FFIDVAQECF
     NIGNFNSLMA IITGMNMNPV SRLKKTWGKV NTDKFDILVH QMDPSSNFYS YRTALRGATQ
     RSSTAHTSQE MIVIPFFSLF IKDIYFLNEG CANRLSNGHI NFEKFWELAK QVSEFLSWRQ
     VICPFERDRK TLQYLISAPV FSEDELQLAS YESEGPENNL ERDTRRSLRS SLSRM
//

If you have problems or comments...

PBIL Back to PBIL home page