(data stored in SCRATCH zone)

SWISSPROT: Q6FJ17_CANGA

ID   Q6FJ17_CANGA            Unreviewed;       344 AA.
AC   Q6FJ17;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   30-AUG-2017, entry version 79.
DE   RecName: Full=tRNA-dihydrouridine synthase {ECO:0000256|PIRNR:PIRNR006621};
DE            EC=1.3.1.- {ECO:0000256|PIRNR:PIRNR006621};
GN   OrderedLocusNames=CAGL0M09911g {ECO:0000313|CGD:CAL0136613,
GN   ECO:0000313|EMBL:CAG62755.1};
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593 {ECO:0000313|Proteomes:UP000002428};
RN   [1] {ECO:0000313|EMBL:CAG62755.1, ECO:0000313|Proteomes:UP000002428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
RC   {ECO:0000313|Proteomes:UP000002428};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.F., Straub M.L., Suleau A.,
RA   Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified
CC       base found in the D-loop of most tRNAs.
CC       {ECO:0000256|PIRNR:PIRNR006621}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006621};
CC   -!- SIMILARITY: Belongs to the dus family.
CC       {ECO:0000256|PIRNR:PIRNR006621}.
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DR   EMBL; CR380959; CAG62755.1; -; Genomic_DNA.
DR   RefSeq; XP_449777.1; XM_449777.1.
DR   ProteinModelPortal; Q6FJ17; -.
DR   STRING; 284593.XP_449777.1; -.
DR   EnsemblFungi; CAG62755; CAG62755; CAGL0M09911g.
DR   KEGG; cgr:CAGL0M09911g; -.
DR   CGD; CAL0136613; CAGL0M09911g.
DR   EuPathDB; FungiDB:CAGL0M09911g; -.
DR   eggNOG; KOG2335; Eukaryota.
DR   eggNOG; COG0042; LUCA.
DR   HOGENOM; HOG000203649; -.
DR   InParanoid; Q6FJ17; -.
DR   KO; K05545; -.
DR   OMA; FRNCVNT; -.
DR   OrthoDB; EOG092C2JF3; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:EnsemblFungi.
DR   CDD; cd02801; DUS_like_FMN; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR035587; DUS-like_FMN-bd.
DR   InterPro; IPR001269; tRNA_hU_synthase.
DR   InterPro; IPR018517; tRNA_hU_synthase_CS.
DR   PANTHER; PTHR11082; PTHR11082; 1.
DR   Pfam; PF01207; Dus; 1.
DR   PIRSF; PIRSF006621; Dus; 1.
DR   PROSITE; PS01136; UPF0034; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q6FJ17.
DR   SWISS-2DPAGE; Q6FJ17.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002428};
KW   Flavoprotein {ECO:0000256|PIRNR:PIRNR006621};
KW   FMN {ECO:0000256|PIRNR:PIRNR006621};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR006621};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002428};
KW   tRNA processing {ECO:0000256|PIRNR:PIRNR006621}.
FT   ACT_SITE    119    119       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006621-1}.
SQ   SEQUENCE   344 AA;  39472 MW;  EE5CFFA1A6931C98 CRC64;
     MIEVPVPKEL TKENDPLHII KTRAQTHGRP ATIAGPMVRY SKLPFRQTCR QYDTDIVYTP
     MILAREFVRN QQARIADLTT NKNDTPLIVQ VGVNNVGDLM KFAEMVAPFC DGIGINCGCP
     IREQIREGIG CALIYNPDLL CEMVKSVKSK YGAKLRLETK IRIHDDWDVT VNLCRRLCDS
     GVDWITIHGR TRTTRSSQPV NLEAIKYIVD KIKDKNVPVV ANGDCFTMKD FKHISDYTGV
     QGVMAVRGVL ANPALFAGHD KCPWGCVEWF WYWTTEYNTL PFALTQHHLY CMLENMGIRR
     KLLKEMMLQR SYPELLDWFD TNFVMHRHGD KEFGTTIDPQ LKTN
//

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